Periconceptional folic acid containing multivitamin supplementation

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 78, Issue 2, 1998, Pages 151-161

  Czeizel, Andrew E ^a  

^a National Institute of Public Health Budapest   (Hungary)

Author keywords

Congenital abnormalities; Folate folic acid; Food fortification; Neural tube defects; Periconceptional multivitamin supplementation

Indexed keywords

ELEVIT PRONATAL; FOLIC ACID; MULTIVITAMIN; UNCLASSIFIED DRUG;

APPETITE DISORDER; CLINICAL TRIAL; CONCEPTION; CONFERENCE PAPER; CONGENITAL MALFORMATION; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; FERTILITY; HUMAN; HUNGARY; NEURAL TUBE DEFECT; PREGNANCY COMPLICATION; PRENATAL CARE; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN ALLERGY; SUPPLEMENTATION; VERTIGO; VITAMIN INTAKE; WEIGHT GAIN;

EID: 0032104612     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(98)00061-X     Document Type: Conference Paper

References (63)

1. [1] Eskes TKAB, Mooij PNM, Steegers-Theunissen RPM, Lips JP, de Pasker-Jong PCM. Prepregnancy care and prevention of birth defects. J Perinat Med 1992;20:253-65.
2. [2] Czeizel AE. Primary prevention of birth defects by periconceptional care including multivitamin supplementation. Bailliere's Clin Obstet Gynecol 1995;9(No. 3):417-30.
3. [3] Czeizel AE, Métneki J, Dudás I. The effect of preconceptional multivitamin supplementation on fertility. Int J Vit Nutr Res 1996;66:55-8.
4. [4] Sanfilippo JS, Lyn YK. Vitamin B deficiency and infertility: report of a case. Int J Fertil 1991;36:86-8.
5. [5] Matte JJ, Girard GL, Brisson GJ. Folic acid and reproductive performance of sows. J Anim Sci 1984;59:1020-5.
6. [6] Czeizel AE, Rockenbauer M, Susánszky É. No change in sexual activity during preconceptional multivitamin supplementation. Br J Obstet Gynecol 1996;103:569-73.
7. [7] Dudás I, Rockenbauer M, Czeizel AE. The effect of preconceptional multivitamin supplementation on the menstrual cycle. Arch Gynecol Obstet 1995;256:111-23.
8. [8] Czeizel AE, Métneki J, Dudás I. Higher rate of multiple births after periconceptional vitamin supplementation. New Engl J Med 1994;330:1687-8.
9. [9] Czeizel AE, Métneki J, Dudás I. The higher rate of multiple birth after periconceptional multivitamin supplementation: an analysis of causes. Acta Genet Med Gemellol 1994;43:175-84.
10. [10] Werler MM, Cragan JD, Wasserman CR, Shaw CR, Erickson JD, Mitchell AA. Multivitamin supplementation and multiple births. Am J Med Genet 1997;71:93-6.
11. [11] Steegers-Theunissen RPM, Steegers EAP, Thomas CMG, Hollanders JMG, Copius Peereboom-Stegeman JJ, Trijbels JMF, Eskes TKAB. Study on the presence of homocysteine in ovarian follicular fluid. Fertil Steril 1993;60:1006-10.
12. [12] Steegers-Theunissen RPM, Steegers EAP, de Boer R, Thomas CMG, Kloosterman MD, Eskes TKAB. Elevated folate levels in amniotic fluid after oral supplementation. Eur J Obstet Gynecol Reprod Biol 1990;36:283-98.
13. [13] Steegers-Theunissen RPM, Boers GHJ, Blom HJ, Nijhuis JG, Thomas CMG, Borm GF, Eskes TKAB. Neural-tube defects and elevated homocysteine levels in amniotic fluid. Am J Obstet Gynecol 1995;172:1436-41.
14. [14] Czeizel AE, Dudás I, Métneki J. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Final results. Arch Gynecol Obstet 1994;255:131-9.
15. [15] Hook EB, Czeizel AE. Can terathanasia explain the protective effect of folic acid supplementation on birth defects?. Lancet 1997;350:513-5.
16. [16] Hall JG, Burn J, Fisk NM, Schorah GJ, Smithells RW, Seller MJ. Terathanasia, folic acid, and birth defects. Lancet 1997;350:1322-3.
17. [17] Hibbard BM. The role of folic acid in pregnancy: with particular reference to anaemia, abruption and abortion. J Obstet Gynaecol Br Commonw 1964;71:529-42.
18. [18] Steegers-Theunissen RPM, Boers GHJ, Blom HJ, Trijbels FJM, Eskes TKAB. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 1992;339:1122-3.
19. [19] Wouters MGAJ, Boers GHJ, Blom HJ, Trijbels JMF, Thomas CMG, Steegers-Theunissen RPM, Eskes TKAB. Hyperhomocysteinaemia: a possible risk factor for women with unexplained recurrent early pregnancy loss?. Fertil Steril 1993;60:820-5.
20. [20] Goddijn-Wessel TAW, Wouters MGAJ, Molen vd EF, Spuijbroek MDEM, Steegers-Theunissen RPM, Blom HJ, Boers GHJ, Eskes TKAB. Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur J Obstet Gynaecol Reprod Biol 1996;66:23-9.
21. [21] Nelen WLDM, Steegers EAP, Eskes TKAB, Blom HJ. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 1997;350:861.
22. [22] Neiger R, Wise C. Contag SA, Tumber MB, Canick JA. First trimester bleeding and pregnancy outcome in gravidas with normal and low folate levels. Am J Perinat 1993;10:460-2.
23. [23] Czeizel AE, Dudás I, Firtz G, Técsoi A, Hanck A, Kunovits G. The effect of periconceptional multivitamin-mineral supplementation for vertigo, nausea and vomiting in the first trimester of pregnancy. Arch Gynecol Obstet 1992;251:181-5.
24. 6 depletion in women with hyperemesis gravidarum. W Klin Wochenschr 1975;87:510-7.
25. [25] Czeizel AE. Prevention of hyperemesis gravidarum is better than its treatment. Am J Obstet Gynecol 1996;174:166.
26. [26] Schwartz SO, Kaplan SR, Armstrong BE. The long-term evaluation of folic acid treatment of pernicious anemia. J Lab Clin Med 1950;35:894-8.
27. [27] Chanarin I, Laidlow J, Lughridge LW, Mollin DL. Megaloblastic anaemia due to phenobarbitone. The convulsant action of therapeutic doses of folic acid. Br Med J 1960;1:1099-102.
28. [28] Chien LT, Krundiesk CL, Scott CW, Butterworth Jr. CE. Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics. Am J Clin Nutr 1975;28:51-8.
29. [29] Strauss RG, Bernstein R. Folic acid and dilantin antagonism in pregnancy. Obstet Gynecol 1975;44:345-8.
30. [30] Boss GR, Ragsdale RA, Lettner A, Seegmiller JE. Failure of folic acid (pteroylgutamic acid) to affect hyperuricemia. J Lab Clin Med 1980;96:783-9.
31. [31] Dansky LV, Andermann E, Rosenblatt D, Sherwin AL, Andermann F. Anticonvulsants, folate levels and pregnancy outcome: a prospective study. Ann Neurol 1987;27:176-82.
32. [32] Czeizel AE, Tomcsik M. Tímár L. Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstet Gynecol 1997;90:195-201.
33. [33] Czeizel AE. Acute toxicity of folic acid in pregnant women. Teratology (submitted).
34. [34] Baxter MG, Miller AA, Webster RA. Some studies on the convulsant action of folic acid. Br J Pharmacol 1973;48:350-1.
35. [35] Olney JW, Fuller TA, de Gubareff T, Labruyere J. Intrastriatal folic acid mimics the distant but not focal brain damaging properties of kainic acid. Neurosci Lett 1981;25:185-91.
36. [36] Hommes OR, Obbens EAMT, Wijfeels CCB. Epileptogenic activity of sodium-folate and the blood-brain barrier in the rat. J Neurol Sci 1973;19:63-71.
37. [37] Biale Y, Lewenthal H. Effects of folic acid supplementation on congenital malformation due to anticonvulsive drugs. Eur J Obstet Gynecol Reprod Biol 1984;18:211-6.
38. [38] Czeizel AE, Dudás I. Prevention of the first occcurrence of neural-tube defects by periconceptional vitamin supplementation. New Engl J Med 1992;327:1832-5.
39. [39] Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, Eskes TKAB. Neural-tube defects and derangement of homocysteine metabolism. New Engl J Med 1991;324:199-200.
40. [40] Van der Put NMJ. Van den Heuvel LP, Steegers-Theunissen RPM, Trijbels JMF, Eskes TKAB, Mariman ECM, Den Heyer M, Blom HJ. Decreased methylenetetrahydrofolate reductase activity due to the 677C-T mutation in families with spina bifida offspring. J Mol Med 1996;74:691-4.
41. [41] Van Der Put NM, Eskes TKAB, Bloom HJ. Is the common 677C →T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. Q J Med 1997;90:111-5.
42. [42] Steegers-Theunissen RPM, Wathen NC, Eskes TKAB, Van Raay-Selten B, Chard T. Is methionine metabolism important during early human pregnancy?. Br J Obstet Gynecol 1997;104:20-4.
43. [43] MRC Vitamin Study Research Group. Prevention of neural-tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-137.
44. [44] CDC. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR 1992;41:1233-1238.
45. 12 are independent risk factors for neural tube defects. Q J Med 1993;86:703-8.
46. 12 metabolism in families with spina bitida offspring. Q J Med 1997;90:505-10.
47. [47] Smithells RW, Sheppard S, Wild J. Prevention of neural-tube defect recurrences in Yorkshire: final report. Lancet 1989;2:498-9.
48. [48] Tolarova M. Periconceptional supplementation with vitamins and folic acid to prevent recurrence of cleft lip. Lancet 1982;2:217.
49. [49] Shaw GM, Lammer EJ, Wasserman CR, O'Malley CD, Tolarova HM. Risk of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 1995;345:393-6.
50. [50] Czeizel AE, Tóth M, Rockenbauer M. Population-based case-control study of folic acid supplementation during pregnancy. Teratology 1996;53:345-51.
51. [51] Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. Br Med J 1993;306:1645-8.
52. [52] Czeizel AE. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet 1996;62:179-83.
53. [53] Li DK, Daling JR, Mueller BA, Hickok DE, Fantel AG, Weiss NS. Periconceptional multivitamin use in relation to the risk of congenital urinary tract anomalies. Epidemiology 1995;6:212-8.
54. [54] Shaw GM, O'Malley CD. Wasserman CR, Tolarova MM, Lammer EJ. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995;59:536-45.
55. [55] Botto LD, Khoury MJ, Mulinare J, Erickson JD. Periconceptional multivitamin use and the occurrence of conotruncal heart defects. Results from a population-based case-control study. Pediatrics 1996;98:911-7.
56. [56] Czeizel AE. Limb-reduction defects and folic acid supplementation. Lancet 1995;345:932.
57. [57] Yang Q, Khoury MJ, Olney RS, Mulinare J. Does periconceptional multivitamin use reduce the risk for limb deficiency in offspring. Epidemiology 1997;8:157-61.
58. [58] McPartlin J, Halligan A, Scott JM, Darling M, Weir DG. Accelerated folate break-down in pregnancy. Lancet 1993;341:148-9.
59. [59] Czeizel AE, Susánszky É. Diet intake and vitamin supplement use of Hungarian women during the preconceptional period. Int J Vit Nutr Res 1994;64:300-5.
60. [60] Cuskelly GJ, McNulty H. Scott JM. Effect of increasing dietary folate on red-cell folate: implications for prevention of neural-tube defects. Lancet 1996;347:657-9.
61. [61] Czeizel AE. Hungarian strategy for periconceptional multivitamin supplementation. Nutriview 4;6-8.
62. [62] Czeizel AE. Bread fortified with three vitamin B. (Hungarian with English abstract). Népegészségügy 1998;in press.
63. [63] Eskes TKAB, Steegers-Theunissen RPM. Primary prevention of neural-tube defects with folic acid. Eur J Obstet Gynecol Reprod Biol 1994;53:147-52.