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Volumn 16, Issue , 2010, Pages 1487-1495

Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes

Author keywords

[No Author keywords available]

Indexed keywords

CANNABIDIOL; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; TYROSINE;

EID: 77955611143     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (21)

References (52)
  • 1
    • 51849157860 scopus 로고    scopus 로고
    • Retinal ganglion cells in diabetes
    • Kern TS, Barber AJ. Retinal ganglion cells in diabetes. J Physiol 2008; 586:4401-8.
    • (2008) J Physiol , vol.586 , pp. 4401-4408
    • Kern, T.S.1    Barber, A.J.2
  • 2
    • 59949099437 scopus 로고    scopus 로고
    • Diabetic retinopathy: Current management and experimental therapeutic targets
    • Ali TK, El-Remessy AB. Diabetic retinopathy: current management and experimental therapeutic targets. Pharmacotherapy 2009; 29:182-92.
    • (2009) Pharmacotherapy , vol.29 , pp. 182-192
    • Ali, T.K.1    El-Remessy, A.B.2
  • 3
    • 34547534847 scopus 로고    scopus 로고
    • Advances in biochemical mechanisms of diabetic retinopathy
    • Giusti C, Gargiulo P. Advances in biochemical mechanisms of diabetic retinopathy. Eur Rev Med Pharmacol Sci 2007; 11:155-63.
    • (2007) Eur Rev Med Pharmacol Sci , vol.11 , pp. 155-163
    • Giusti, C.1    Gargiulo, P.2
  • 4
    • 0034493893 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine
    • Kowluru RA, Engerman RL, Kern TS. Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine. Curr Eye Res 2000; 21:814-9.
    • (2000) Curr Eye Res , vol.21 , pp. 814-819
    • Kowluru, R.A.1    Engerman, R.L.2    Kern, T.S.3
  • 5
    • 33749070956 scopus 로고    scopus 로고
    • Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress
    • Kowluru RA, Kowluru V, Xiong Y, Ho YS. Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Free Radic Biol Med 2006; 41:1191-6.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1191-1196
    • Kowluru, R.A.1    Kowluru, V.2    Xiong, Y.3    Ho, Y.S.4
  • 6
    • 0036319333 scopus 로고    scopus 로고
    • Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine
    • Du Y, Smith MA, Miller CM, Kern TS. Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine. J Neurochem 2002; 80:771-9.
    • (2002) J Neurochem , vol.80 , pp. 771-779
    • Du, Y.1    Smith, M.A.2    Miller, C.M.3    Kern, T.S.4
  • 7
    • 0036306098 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
    • Romeo G, Liu WH, Asnaghi V, Kern TS, Lorenzi M. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes 2002; 51:2241-8.
    • (2002) Diabetes , vol.51 , pp. 2241-2248
    • Romeo, G.1    Liu, W.H.2    Asnaghi, V.3    Kern, T.S.4    Lorenzi, M.5
  • 8
    • 0034625764 scopus 로고    scopus 로고
    • Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: Effect of -[alpha]-lipoic acid
    • Obrosova IG, Fathallah L, Greene DA. Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of -[alpha]-lipoic acid. Eur J Pharmacol 2000; 398:139-46.
    • (2000) Eur J Pharmacol , vol.398 , pp. 139-146
    • Obrosova, I.G.1    Fathallah, L.2    Greene, D.A.3
  • 10
    • 0038243821 scopus 로고    scopus 로고
    • Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor
    • El-Remessy AB, Behzadian MA, Abou-Mohamed G, Franklin T, Caldwell RW, Caldwell RB. Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am J Pathol 2003; 162:1995-2004.
    • (2003) Am J Pathol , vol.162 , pp. 1995-2004
    • El-Remessy, A.B.1    Behzadian, M.A.2    Abou-Mohamed, G.3    Franklin, T.4    Caldwell, R.W.5    Caldwell, R.B.6
  • 11
    • 14044265526 scopus 로고    scopus 로고
    • Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    • El-Remessy AB, Bartoli M, Platt DH, Fulton D, Caldwell RB. Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J Cell Sci 2005; 118:243-52.
    • (2005) J Cell Sci , vol.118 , pp. 243-252
    • El-Remessy, A.B.1    Bartoli, M.2    Platt, D.H.3    Fulton, D.4    Caldwell, R.B.5
  • 12
    • 30344486638 scopus 로고    scopus 로고
    • Neuroprotective and Blood-retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
    • El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI. Neuroprotective and Blood-retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes. Am J Pathol 2006; 168:235-44.
    • (2006) Am J Pathol , vol.168 , pp. 235-244
    • El-Remessy, A.B.1    Al-Shabrawey, M.2    Khalifa, Y.3    Tsai, N.T.4    Caldwell, R.B.5    Liou, G.I.6
  • 13
    • 42449100783 scopus 로고    scopus 로고
    • Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes
    • Ali TK, Matragoon S, Pillai BA, Liou GI, El-Remessy AB. Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. Diabetes 2008; 57:889-98.
    • (2008) Diabetes , vol.57 , pp. 889-898
    • Ali, T.K.1    Matragoon, S.2    Pillai, B.A.3    Liou, G.I.4    El-Remessy, A.B.5
  • 16
    • 0031919598 scopus 로고    scopus 로고
    • Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group
    • Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D, Strother JM. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes 1998; 47:815-20.
    • (1998) Diabetes , vol.47 , pp. 815-820
    • Lieth, E.1    Barber, A.J.2    Xu, B.3    Dice, C.4    Ratz, M.J.5    Tanase, D.6    Strother, J.M.7
  • 17
    • 0033843835 scopus 로고    scopus 로고
    • Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group
    • Lieth E, LaNoue KF, Antonetti DA, Ratz M. Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group. Exp Eye Res 2000; 70:723-30.
    • (2000) Exp Eye Res , vol.70 , pp. 723-730
    • Lieth, E.1    Lanoue, K.F.2    Antonetti, D.A.3    Ratz, M.4
  • 18
    • 0036725651 scopus 로고    scopus 로고
    • Diabetes-induced dysfunction of the glutamate transporter in retinal Muller cells
    • Li Q, Puro DG. Diabetes-induced dysfunction of the glutamate transporter in retinal Muller cells. Invest Ophthalmol Vis Sci 2002; 43:3109-16.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 3109-3116
    • Li, Q.1    Puro, D.G.2
  • 19
    • 0030987654 scopus 로고    scopus 로고
    • Elevated gammaaminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy
    • Ambati J, Chalam KV, Chawla DK, D'Angio CT, Guillet EG, Rose SJ, Vanderlinde RE, Ambati BK. Elevated gammaaminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch Ophthalmol 1997; 115:1161-6.
    • (1997) Arch Ophthalmol , vol.115 , pp. 1161-1166
    • Ambati, J.1    Chalam, K.V.2    Chawla, D.K.3    D'angio, C.T.4    Guillet, E.G.5    Rose, S.J.6    Vanderlinde, R.E.7    Ambati, B.K.8
  • 22
    • 17844375087 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat
    • Görg B, Wettstein M, Metzger S, Schliess F, Häussinger D. Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat. Hepatology 2005; 41:1065-73.
    • (2005) Hepatology , vol.41 , pp. 1065-1073
    • Görg, B.1    Wettstein, M.2    Metzger, S.3    Schliess, F.4    Häussinger, D.5
  • 23
    • 0036488182 scopus 로고    scopus 로고
    • Neuroprotective properties of cannabinoids against oxidative stress: Role of the cannabinoid receptor CB1
    • Marsicano G, Moosmann B, Hermann H, Lutz B, Behl C. Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem 2002; 80:448-56.
    • (2002) J Neurochem , vol.80 , pp. 448-456
    • Marsicano, G.1    Moosmann, B.2    Hermann, H.3    Lutz, B.4    Behl, C.5
  • 24
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: Dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    • Shohami E, Gallily R, Mechoulam R, Bass R, Ben-Hur T. Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J Neuroimmunol 1997; 72:169-77.
    • (1997) J Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben-Hur, T.5
  • 25
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 1998; 95:8268-73.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 26
    • 0037707636 scopus 로고    scopus 로고
    • Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils
    • Braida D, Pegorini S, Arcidiacono MV, Consalez GG, Croci L, Sala M. Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils. Neurosci Lett 2003; 346:61-4.
    • (2003) Neurosci Lett , vol.346 , pp. 61-64
    • Braida, D.1    Pegorini, S.2    Arcidiacono, M.V.3    Consalez, G.G.4    Croci, L.5    Sala, M.6
  • 28
    • 0018873987 scopus 로고
    • Glucocorticoid stimulation of glutamine synthetase production in cultured rat glioma cells
    • Pishak MR, Phillips AT. Glucocorticoid stimulation of glutamine synthetase production in cultured rat glioma cells. J Neurochem 1980; 34:866-72.
    • (1980) J Neurochem , vol.34 , pp. 866-872
    • Pishak, M.R.1    Phillips, A.T.2
  • 29
    • 0030680073 scopus 로고    scopus 로고
    • Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes
    • Gamberino WC, Berkich DA, Lynch CJ, Xu B, LaNoue KF. Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes. J Neurochem 1997; 69:2312-25.
    • (1997) J Neurochem , vol.69 , pp. 2312-2325
    • Gamberino, W.C.1    Berkich, D.A.2    Lynch, C.J.3    Xu, B.4    Lanoue, K.F.5
  • 31
    • 0037317423 scopus 로고    scopus 로고
    • A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    • Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M. A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat. Diabetes 2003; 52:506-11.
    • (2003) Diabetes , vol.52 , pp. 506-511
    • Asnaghi, V.1    Gerhardinger, C.2    Hoehn, T.3    Adeboje, A.4    Lorenzi, M.5
  • 32
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin
    • Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 1998; 102:783-91.
    • (1998) J Clin Invest , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3    Antonetti, D.A.4    Buchanan, A.G.5    Gardner, T.W.6
  • 33
    • 47649126432 scopus 로고    scopus 로고
    • Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis
    • Drel VR, Pacher P, Ali TK, Shin J, Julius U, El-Remessy AB, Obrosova IG. Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. Int J Mol Med 2008; 21:667-76.
    • (2008) Int J Mol Med , vol.21 , pp. 667-676
    • Drel, V.R.1    Pacher, P.2    Ali, T.K.3    Shin, J.4    Julius, U.5    El-Remessy, A.B.6    Obrosova, I.G.7
  • 35
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996; 19:312-8.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 36
    • 34250328361 scopus 로고    scopus 로고
    • Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: Model of diabetic retinopathy
    • Shelton MD, Kern TS, Mieyal JJ. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: model of diabetic retinopathy. J Biol Chem 2007; 282:12467-74.
    • (2007) J Biol Chem , vol.282 , pp. 12467-12474
    • Shelton, M.D.1    Kern, T.S.2    Mieyal, J.J.3
  • 37
    • 0345120947 scopus 로고    scopus 로고
    • Requirement for nitric oxide in retinal neuronal cell death induced by activated Muller glial cells
    • Goureau O, Regnier-Ricard F, Courtois Y. Requirement for nitric oxide in retinal neuronal cell death induced by activated Muller glial cells. J Neurochem 1999; 72:2506-15.
    • (1999) J Neurochem , vol.72 , pp. 2506-2515
    • Goureau, O.1    Regnier-Ricard, F.2    Courtois, Y.3
  • 38
    • 58849097068 scopus 로고    scopus 로고
    • Dietary taurine supplementation prevents glial alterations in retina of diabetic rats
    • Zeng K, Xu H, Mi M, Zhang Q, Zhang Y, Chen K, Chen F, Zhu J, Yu X. Dietary taurine supplementation prevents glial alterations in retina of diabetic rats. Neurochem Res 2009; 34:244-54.
    • (2009) Neurochem Res , vol.34 , pp. 244-254
    • Zeng, K.1    Xu, H.2    Mi, M.3    Zhang, Q.4    Zhang, Y.5    Chen, K.6    Chen, F.7    Zhu, J.8    Yu, X.9
  • 40
    • 67651163925 scopus 로고    scopus 로고
    • Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Muller glial cells
    • Mysona B, Dun Y, Duplantier J, Ganapathy V, Smith SB. Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Muller glial cells. Cell Tissue Res 2009; 335:477-88.
    • (2009) Cell Tissue Res , vol.335 , pp. 477-488
    • Mysona, B.1    Dun, Y.2    Duplantier, J.3    Ganapathy, V.4    Smith, S.B.5
  • 41
    • 0032539899 scopus 로고    scopus 로고
    • Carbon dioxide stimulates peroxynitrite-mediated nitration of tyrosine residues and inhibits oxidation of methionine residues of glutamine synthetase: Both modifications mimic effects of adenylylation
    • Berlett BS, Levine RL, Stadtman ER. Carbon dioxide stimulates peroxynitrite-mediated nitration of tyrosine residues and inhibits oxidation of methionine residues of glutamine synthetase: both modifications mimic effects of adenylylation. Proc Natl Acad Sci USA 1998; 95:2784-9.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2784-2789
    • Berlett, B.S.1    Levine, R.L.2    Stadtman, E.R.3
  • 42
    • 70350732811 scopus 로고    scopus 로고
    • Timedependent reduction of glutamine synthetase in retina of diabetic rats
    • Yu XH, Zhang H, Wang YH, Liu LJ, Teng Y, Liu P. Timedependent reduction of glutamine synthetase in retina of diabetic rats. Exp Eye Res 2009; 89:967-71.
    • (2009) Exp Eye Res , vol.89 , pp. 967-971
    • Yu, X.H.1    Zhang, H.2    Wang, Y.H.3    Liu, L.J.4    Teng, Y.5    Liu, P.6
  • 43
    • 70350666818 scopus 로고    scopus 로고
    • Role of IL-1beta on the glutamine synthetase in retinal Muller cells under high glucose conditions
    • Shen X, Xu G. Role of IL-1beta on the glutamine synthetase in retinal Muller cells under high glucose conditions. Curr Eye Res 2009; 34:727-36.
    • (2009) Curr Eye Res , vol.34 , pp. 727-736
    • Shen, X.1    Xu, G.2
  • 44
    • 77949879018 scopus 로고    scopus 로고
    • Glyceraldehyde 3 phosphate dehydrogenase in retinal microvasculature: Implications for the development and progression of diabetic retinopathy
    • Madsen-Bouterse S, Mohammad G, Kowluru RA. Glyceraldehyde 3 phosphate dehydrogenase in retinal microvasculature: Implications for the development and progression of diabetic retinopathy. Invest Ophthalmol Vis Sci 2009; 51:1765-72.
    • (2009) Invest Ophthalmol Vis Sci , vol.51 , pp. 1765-1772
    • Madsen-Bouterse, S.1    Mohammad, G.2    Kowluru, R.A.3
  • 46
    • 0036098197 scopus 로고    scopus 로고
    • High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells
    • Zou MH, Shi C, Cohen RA. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes 2002; 51:198-203.
    • (2002) Diabetes , vol.51 , pp. 198-203
    • Zou, M.H.1    Shi, C.2    Cohen, R.A.3
  • 47
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993; 262:689-95.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 49
    • 38449119665 scopus 로고    scopus 로고
    • Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats
    • Kusari J, Zhou S, Padillo E, Clarke KG, Gil DW. Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 2007; 48:5152-9.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 5152-5159
    • Kusari, J.1    Zhou, S.2    Padillo, E.3    Clarke, K.G.4    Gil, D.W.5
  • 52
    • 33645816506 scopus 로고    scopus 로고
    • Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
    • Barnes MP. Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain. Expert Opin Pharmacother 2006; 7:607-15.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 607-615
    • Barnes, M.P.1


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