What is known about the antiviral agents active against bovine viral diarrhea virus (BVDV)?

Current Medicinal Chemistry

Volumn 17, Issue 26, 2010, Pages 2933-2955

  Finkielsztein, L M ^a   Moltrasio, G Y ^a   Caputto, M E ^a   Castro, E F ^a   Cavallaro, L V ^a   Moglioni, A G ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antiviral agents; BVDV; HCV; Non nucleosidic compounds; Nucleosidic compounds; Structure activity relationship

Indexed keywords

1 MORPHOLINO PIPERIDINOMETHYL 5 NITRO INDOLE 2,3 DIONE 3 THIOSEMICARBAZONE DERIVATIVE; 2 METHYLIMIDAZO[1,2 A]PYRROLO[2,3 C]PYRIDIN 8 CARBOXYLATE; 3 (BETA DEXTRO RIBOFURANOSYL) 6 DECYL 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 5 [(4 BROMOPHENYL)METHYL] 2 PHENYL 5H IMIDAZO[4,5 C]PYRIDINE; 5 BENZYL 2 PHENY 5H IMIDAZO[4,5 C]PYRIDINE; 5 NITRO 1H INDOLE 2,3 DIONE 3 THIOSEMICARBAZONE DERIVATIVE; 5 NITRO 3 [(5 METHYL 4 THIAZOLIDINONE 2 YLIDENE)HYDRAZONO] 1H 2 INDOLINONE DERIVATIVE; [3 [[(2 DIPROPYLAMINO)ETHYL]THIO] 5H 1,2,4 TRIAZINO[5,6 B]INDOLE]; ADENINE DERIVATIVE; AG 110; ANTIVIRUS AGENT; AZATHIOPRINE; BETA DEXTRO N 4 HYDROXYCYTIDINE; DPC A69280 29; FEG 118; FEVB 28; INOSINE PHOSPHATE; MIZORIBINE; MYCOPHENOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEOSIDE DERIVATIVE; PYRIDINE DERIVATIVE; RIBAVIRIN; UNCLASSIFIED DRUG; VP 32947;

ARTICLE; BOVINE VIRAL DIARRHEA; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; BOVINE VIRUS DIARRHEA-MUCOSAL DISEASE; CATTLE; DIARRHEA VIRUSES, BOVINE VIRAL; DRUG DESIGN; NUCLEOSIDES;

EID: 77955610492     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710792065036     Document Type: Article

References (91)

1. Collett, M. S.; Larson, R.; Belzer, S. K.; Retzel, E. Proteins encoded by bovine viral diarrhea virus: the genomic organization of a pestivirus. Virology 1988, 165, 200-8.
2. Donis, R. O.; Corapi, W. V.; Dubovi, E. J. Bovine viral diarrhea virus proteins and their antigenic analyses. Arch. Virol. Suppl. 1991, 3, 29-40.
3. Baker, J. C. Bovine viral diarrhea virus: a review. J. Am. Vet. Med. Assoc. 1987, 190, 1449-58
4. Nettleton, P. F.; Entrican, G. Ruminant pestiviruses. Br. Vet. J. 1995, 151, 615-42.
5. Pastoret, P. P.; Lambot, M. Biology of bovine pestivirus infection responsible for mucosal disease. Bull. Mem. Acad. R. Med. Belg. 1995, 150, 244-50.
6. Hewicker-Trautwein, M.; Liess, B.; Trautwein, G. Brain lesions in calves following transplacental infection with bovine-virus diarrhoea virus. Zentralbl. Veterinarmed. B. 1995, 42, 65-77.
7. Liebler-Tenorio, E. M.; Pohlenz, J. F. Experimental mucosal disease of cattle: changes in cell proliferation in lymphoid tissues and intestinal epithelium. J. Comp. Pathol. 1997, 117, 339-50.
8. Liebler-Tenorio, E. M.; Greiser-Wilke, I.; Pohlenz, J. F. Organ and tissue distribution of the antigen of the cytopathogenic bovine virus diarrhea virus in the early and advanced phase of experimental mu-cosal disease. Arch. Virol. 1997, 142, 1613-34.
9. Ellis, J. A.; West, K. H.; Cortese, V. S.; Myers, S. L.; Carman, S.; Martin, K. M.; Haines, D. M. Lesions and distribution of viral antigen following an experimental infection of young seronegative calves with virulent bovine virus diarrhea virus-type II. Can. J. Vet. Res. 1998, 62, 161-9.
10. Donis, R. O.; Dubovi, E. J. Differences in virus-induced polypep-tides in cells infected by cytopathic and noncytopathic biotypes of bovine virus diarrhea-mucosal disease virus. Virology 1987, 158, 168-73.
11. Kummerer, B. M.; Stoll, D.; Meyers, G. Bovine viral diarrhea virus strain Oregon: a novel mechanism for processing of NS2-3 based on point mutations. J. Virol. 1998, 72, 4127-38.
12. Houe, H. Economic impact of BVDV infection in dairies. Biologi-cals 2003, 31, 137-43.
13. Yanagi, M.; Bukh, J.; Emerson, S. U.; Purcell, R. H. Contamination of commercially available fetal bovine sera with bovine viral diarrhea virus genomes: implications for the study of hepatitis C virus in cell cultures. J. Infect. Dis. 1996, 174, 1324-7.
14. Bolin, S. R.; Matthews, P. J.; Ridpath, J. F. Methods for detection and frequency of contamination of fetal calf serum with bovine viral diarrhea virus and antibodies against bovine viral diarrhea virus. J. Vet. Diagn. Invest. 1991, 3, 199-203.
15. Harasawa, R.; Mizusawa, H. Demonstration and genotyping of pestivirus RNA from mammalian cell lines. Microbiol. Immunol. 1995, 39, 979-85.
16. Harasawa, R.; Tomiyama, T. Evidence of pestivirus RNA in human virus vaccines. J. Clin. Microbiol. 1994, 32, 1604-5.
17. Giangaspero, M.; Vacirca, G.; Harasawa, R.; Buttner, M.; Panuc-cio, A.; De Giuli Morghen, C.; Zanetti, A.; Belloli, A.; Verhulst, A. Genotypes of pestivirus RNA detected in live virus vaccines for human use. J. Vet. Med. Sci. 2001, 63, 723-33.
18. Harasawa, R.; Sasaki, T. Sequence analysis of the 5' untranslated region of pestivirus RNA demonstrated in interferons for human use. Biologicals 1995, 23, 263-9.
19. Kim, W. R.; Brown, R. S., Jr.; Terrault, N. A.; El-Serag, H. Burden of liver disease in the United States: summary of a workshop. He- patology 2002, 36, 227-42.
20. Larkin, J.; Jin, L.; Farmen, M.; Venable, D.; Huang, Y.; Tan, S. L.; Glass, J. I. Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system. J. Interferon Cy-tokine Res. 2003, 23, 247-57.
21. Buckwold, V. E.; Beer, B. E.; Donis, R. O. Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents. Antiviral. Res. 2003, 60, 1-15
22. Vassilev, V. B.; Collett, M. S.; Donis, R. O. Authentic and chimeric full-length genomic cDNA clones of bovine viral diarrhea virus that yield infectious transcripts. J. Virol. 1997, 71, 471-8.
23. Meyers, G.; Tautz, N.; Becher, P.; Thiel, H. J.; Kummerer, B. M. Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs. J. Virol. 1996, 70, 860613.
24. Enomoto, N.; Sakuma, I.; Asahina, Y.; Kurosaki, M.; Murakami, T.; Yamamoto, C.; Izumi, N.; Marumo, F.; Sato, C. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J. Clin. Invest. 1995, 96, 224-30.
25. D'Abramo, C. M.; Cellai, L.; Gotte, M. Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases. J. Mol. Biol. 2004, 337, 1-14.
26. Nehls, S.; Snapp, E. L.; Cole, N. B.; Zaal, K. J.; Kenworthy, A. K.; Roberts, T. H.; Ellenberg, J.; Presley, J. F.; Siggia, E.; Lippincott-Schwartz, J. Dynamics and retention of misfolded proteins in native ER membranes. Nat. Cell. Biol. 2000, 2, 288-95.
27. Buckwold, V. E.; Wei, J.; Wenzel-Mathers, M.; Russell, J. Synergistic in vitro interactions between alpha interferon and ribavirin against bovine viral diarrhea virus and yellow fever virus as surrogate models of hepatitis C virus replication. Antimicrob. Agents Chemother. 2003, 47, 2293-8.
28. Yanagida, K.; Baba, C.; Baba, M. Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-alpha. Antiviral. Res 2004, 64, 195-201.
29. Stuyver, L. J.; Lostia, S.; Patterson, S. E.; Clark, J. L.; Watanabe, K. A.; Otto, M. J.; Pankiewicz, K. W. Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents. Antivir. Chem. Chemother. 2002, 13, 345-52.
30. Stuyver, L. J.; Whitaker, T.; McBrayer, T. R.; Hernandez-Santiago, B. I.; Lostia, S.; Tharnish, P. M.; Ramesh, M.; Chu, C. K.; Jordan, R.; Shi, J.; Rachakonda, S.; Watanabe, K. A.; Otto, M. J.; Schinazi, R. F. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture. Antimicrob. Agents Chemother. 2003, 47, 244-54.
31. Hollecker, L.; Choo, H.; Chong, Y.; Chu, C. K.; Lostia, S.; McBrayer, T. R.; Stuyver, L. J.; Mason, J. C.; Du, J.; Rachakonda, S.; Shi, J.; Schinazi, R. F.; Watanabe, K. A. Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture. Antivir. Chem. Chemother. 2004, 15, 43-55.
32. Seio, K.; Sasaki, T.; Yanagida, K.; Baba, M.; Sekine, M. Synthesis of benzodithiol-2-yl-substituted nucleoside derivatives as lead compounds having anti-bovine viral diarrhea virus activity. J. Med. Chem. 2004, 47, 5265-75.
33. Dukhan, D.; Leroy, F.; Peyronnet, J.; Bosc, E.; Chaves, D.; Durka, M.; Storer, R.; La Colla, P.; Seela, F.; Gosselin, G. Synthesis of 5-aza-7-deazaguanine nucleoside derivatives as potential anti-flavivirus agents. Nucleosides Nucleotides Nucleic Acids 2005, 24, 671-4.
34. Pierra, C.; Amador, A.; Badaroux, E.; Storer, R.; Gosselin, G. Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents Collect. Czech. Chem. Commun. 2006, 71, 991-1010.
35. Stangl, J. R.; Carroll, K. L.; Illichmann, M.; Striker, R. Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus. Transplantation 2004, 77, 562-7.
36. Hoover, S.; Striker, R. Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner. J. Gen. Virol. 2008, 89, 1000-9.
37. Manfredini, S.; Angusti, A.; Veronese, A. C.; Durini, E.; Vertuani, S.; Nalin, F.; Solaroli, N.; Pricl, S.; Ferrone, M.; Mura, M.; Piano, M. A.; Poddesu, B.; Cadeddu, A.; La Colla, P.; Loddo, R. Hindered nucleoside analogs as antiflaviviridae agents. Pure Appl. Chem. 2004, 76, 1007-1015.
38. Angusti, A., Manfredini, S., Durini, E., Ciliberti, N., Vertuani, S., Solaroli, N., Pricl, S., Ferrone, M., Fermeglia, M., Loddo, R., Secci, B., Visioli, A., Sanna, T., Collu, G., Pezzullo, M., La Colla, P. Design, synthesis and anti flaviviridae activity of N(6)-, 5',3'-O-and 5',2'-O-substituted adenine nucleoside analogs. Chem Pharm Bull 2008, 56, 423-32.
39. Ivanov, M. A.; Ivanov, A. V.; Krasnitskaia, I. A.; Smirnova, O. A.; Karpenko, I. L.; Belanov, E. F.; Prasolov, V. S.; Tunitskaia, V. L.; Aleksandrova, L. A. New furano- and pyrrolo[2,3-d]pyrimidine nucleosides and their 5'-triphosphates: synthesis and biological properties. Bioorg. Khim. 2008, 34, 661-70.
40. King, R. W.; Scarnati, H. T.; Priestley, E. S.; De Lucca, I.; Bansal, A.; Williams, J. K. Selection of a thiazole urea-resistant variant of bovine viral diarrhoea virus that maps to the RNA-dependent RNA polymerase. Antivir. Chem. Chemother. 2002, 13, 315-23.
41. Sun, J. H.; Lemm, J. A.; O'Boyle, D. R., 2nd; Racela, J.; Colonno, R.; Gao, M. Specific inhibition of bovine viral diarrhea virus repli-case. J. Virol. 2003, 77, 6753-60.
42. Givens, M. D.; Dykstra, C. C.; Brock, K. V.; Stringfellow, D. A.; Kumar, A.; Stephens, C. E.; Goker, H.; Boykin, D. W. Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules. Antimicrob. Agents Chemother. 2003, 47, 2223-30.
43. Puerstinger, G.; Paeshuyse, J.; Herdewijn, P.; Rozenski, J.; De Clercq, E.; Neyts, J. Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. Bioorg. Med. Chem. Lett. 2006, 16, 5345-9.
44. Paeshuyse, J.; Leyssen, P.; Mabery, E.; Boddeker, N.; Vrancken, R.; Froeyen, M.; Ansari, I. H.; Dutartre, H.; Rozenski, J.; Gil, L. H.; Letellier, C.; Lanford, R.; Canard, B.; Koenen, F.; Kerkhofs, P.; Donis, R. O.; Herdewijn, P.; Watson, J.; De Clercq, E.; Puerstinger, G; Neyts, J. A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase. J. Virol. 2006, 80, 149-60.
45. Puerstinger, G.; Paeshuyse, J.; De Clercq, E.; Neyts, J. Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity. Bioorg. Med. Chem. Lett. 2007, 17, 390-3.
46. Puerstinger, G.; Paeshuyse, J.; Heinrich, S.; Mohr, J.; Schraffl, N.; De Clercq, E.; Neyts, J. Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity. Bioorg. Med. Chem. Lett. 2007, 17, 5111-4.
47. Tonelli, M.; Paglietti, G.; Boido, V.; Sparatore, F.; Marongiu, F.; Marongiu, E.; La Colla, P.; Loddo, R. Antiviral activity of ben-zimidazole derivatives. I. Antiviral activity of 1-substituted-2-[(benzotriazol-1/2-yl)methyl]benzimidazoles. Chem. Biodivers. 2008, 5, 2386-401.
48. Baginski, S. G.; Pevear, D. C.; Seipel, M.; Sun, S. C.; Benetatos, C. A.; Chunduru, S. K.; Rice, C. M.; Collett, M. S. Mechanism of action of a pestivirus antiviral compound. Proc. Natl. Acad. Sci. U S A 2000, 97, 7981-6.
49. Tabarrini, O.; Manfroni, G.; Fravolini, A.; Cecchetti, V.; Sabatini, S.; De Clercq, E.; Rozenski, J.; Canard, B.; Dutartre, H.; Paeshuyse, J.; Neyts, J. Synthesis and anti-BVDV activity of acri-dones as new potential antiviral agents. J. Med. Chem. 2006, 49, 2621-7.
50. Carta, A.; Loriga, M.; Paglietti, G.; Ferrone, M.; Fermeglia, M.; Pricl, S.; Sanna, T.; Ibba, C.; La Colla, P.; Loddo, R. Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses. Bioorg. Med. Chem. 2007, 15, 1914-27.
51. Paeshuyse, J.; Chezal, J. M.; Froeyen, M.; Leyssen, P.; Dutartre, H.; Vrancken, R.; Canard, B.; Letellier, C.; Li, T.; Mittendorfer, H.; Koenen, F.; Kerkhofs, P.; De Clercq, E.; Herdewijn, P.; Pu-erstinger, G.; Gueiffier, A.; Chavignon, O.; Teulade, J. C.; Neyts, J. The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication. J. Virol 2007, 81, 11046-53.
52. Sako, K.; Aoyama, H.; Sato, S.; Hashimoto, Y.; Baba, M. y-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity. Bioorg. Med. Chem. 2008, 16, 3780-90.
53. Simpson, W.; Smith, A. J. Factors affecting antibacterial activity of hop compounds and their derivatives. J. Appl. Bacteriol. 1992, 72, 327-34
54. Tagashira, T.; Watanabe, W.; Uernatsu, N. Antioxidative Activity of Hop Bitter Acids and their Analogues. Biosci. Biotech. Biochem. 1995, 59, 740-742.
55. Buckwold, V. E.; Wilson, R. J.; Nalca, A.; Beer, B. B.; Voss, T. G.; Turpin, J. A.; Buckheit, R. W., 3rd; Wei, J.; Wenzel-Mathers, M.; Walton, E. M.; Smith, R. J.; Pallansch, M.; Ward, P.; Wells, J.; Chuvala, L.; Sloane, S.; Paulman, R.; Russell, J.; Hartman, T.; Ptak, R. Antiviral activity of hop constituents against a series of DNA and RNA viruses. Antiviral. Res. 2004, 61, 57-62.
56. Mazzei, M.; Nieddu, E.; Miele, M.; Balbi, A.; Ferrone, M.; Fer-meglia, M.; Mazzei, M. T.; Pricl, S.; La Colla, P.; Marongiu, F.; Ibba, C.; Loddo, R. Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae. Bioorg. Med. Chem. 2008, 16, 2591-605.
57. Giampieri, M.; Balbi, A.; Mazzei, M.; La Colla, P.; Ibba, C.; Loddo, R. Antiviral activity of indole derivatives. Antiviral. Res. 2009, 83, 179-85.
58. Terzioglu, N. K., N.; Giirsoy, A.; Pannecouque, C.; Leysen, P.; Paeshuyse, J.; Neyts, J.; De Clercq, E. Synthesis and primary antiviral activity of 3-hydrazono-5-nitro-2-indolinone derivatives. Arkivoc 2006, i, 109-118.
59. Finkielsztein, L. M.; Castro, E. F.; Fabian, L. E.; Moltrasio, G. Y.; Campos, R. H.; Cavallaro, L. V.; Moglioni, A. G. New 1-indanone thiosemicarbazone derivatives active against BVDV. Eur. J. Med. Chem. 2008, 43, 1767-73.
60. Tonelli, M.; Boido, V.; Canu, C.; Sparatore, A.; Sparatore, F.; Paneni, M. S.; Fermeglia, M.; Pricl, S.; La Colla, P.; Casula, L.; Ibba, C.; Collu, D.; Loddo, R. Antimicrobial and cytotoxic aryla-zoenamines. Part III: antiviral activity of selected classes of aryla-zoenamines. Bioorg. Med. Chem. 2008, 16, 8447-65.
61. Tonelli, M.; Vazzana, I.; Tasso, B.; Boido, V.; Sparatore, F.; Fer-meglia, M.; Paneni, M. S.; Posocco, P.; Pricl, S.; La Colla, P.; Ibba, C.; Secci, B.; Collu, G.; Loddo, R. Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives. Bioorg. Med. Chem. 2009, 17, 4425-40.
62. Srinivasan, J.; Cheatham III, T. E.; Cieplak, P.; Kollman, P. A.; Case, D. A. Continuum Solvent Studies of the Stability of DNA, RNA, and Phosphoramidate-DNA Helices J. Am. Chem. Soc. 1998, 120, 9401-9.
63. Tautz, N.; Kaiser, A.; Thiel, H. NS3 Serine protease of bovine viral diarrhea virus: Characterization of active site residues, NS4A co-factor domain, and protease-cofactor interactions. Virology 2000, 273, 351-63.
64. Koehler, K. A.; Lienhard, G. E. 2-phenylethaneboronic acid, a possible transition-state analog for chymotrypsin. Biochemistry 1971, 10, 2477-83.
65. Kettner, C. A.; Shenvi, A. B. Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymo-trypsin by peptide boronic acids. J. Biol. Chem. 1984, 259, 1510614.
66. Buhkhtiyarova, M.; Rizzo, C.; Kettner, C.; Korant, B.; Scarnati, H. T.; King, R. Inhibition of the bovine viral diarrhoea virus NS3 ser-ine protease by a boron-modified peptidyl mimetic of its natural substrate. Antimicrob. Agents Chemother. 2002, 12, 367-73.
67. Alonzi, D. S.; Dwek, R. A.; Butters, T. D. Improved cellular inhibitors for glycoprotein processing α-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycin. Tetrahedron: Asymmetry 2009, 20, 897-901.
68. Inouye, S.; Tsuruoka, T.; Nida, T. The structure of nojirimycin, a piperidinose sugar antibiotic. J. Antibiot. (Tokyo) 1966, 19, 288-92.
69. Borges de Melo, E.; da Silveira Gomes, A.; Carvalho, I. a- and p-Glucosidase inhibitors: chemical structure and biological activity Tetrahedron 2006, 62, 10277-302.
70. Zitzmann, N.; Mehta, A. S.; Carrouee, S.; Butters, T. D.; Platt, F. M.; McCauley, J.; Blumberg, B. S.; Dwek, R. A.; Block, T. M. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 11878-82.
71. Branza-Nichita, N.; Durantel, D.; Carrouee-Durantel, S.; Dwek, R. A.; Zitzmann, N. Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers. J. Virol. 2001, 75, 3527-36.
72. Durantel, D.; Branza-Nichita, N.; Carrouee-Durantel, S.; Butters, T. D.; Dwek, R. A.; Zitzmann, N. Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus. J. Virol. 2001, 75, 8987-98.
73. Butters, T. D.; Dwek, R. A.; Platt, F. M. Inhibition of glycosphin-golipid biosynthesis: application to lysosomal storage disorders. Chem. Rev. 2000, 100, 4683-96.
74. Mehta, A.; Ouzounov, S.; Jordan, R.; Simsek, E.; Lu, X.; Moriarty, R. M.; Jacob, G.; Dwek, R. A.; Block, T. M. Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. Antiviral. Chem. Chemother. 2002, 13, 299-304.
75. Gu, B.; Mason, P.; Wang, L.; Norton, P.; Bourne, N.; Moriarty, R.; Metha, A.; Despande, M.; Shah, R.; Block, T. Antiviral profiles of novel iminonocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus. Antiviral Chem. Chemother. 2007, 18, 49-59.
76. Alonzi, D.; Dwek, R.; Butters, T. Improved cellular inhibitors for glycoprotein processing a-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins. Tetrahedron: Asymmetry 2009, 20, 897-901
77. Cronin, L.; Murphy, P. V. Novel synthesis of castanospermine and 1-epicastanospermine. Org. Lett. 2005, 7, 2691-3.
78. Wu, T.; Huang, P. A concise approach to (+)-1-epi-castanospermine Tetrahedron Lett. 2008, 49, 383-86.
79. Machan, T.; Davis, A.; Liawruangrath, B.; Pyne, S. Synthesis of castanospermine. Tetrahedron 2008, 64, 2725-32
80. Sorbera, L. A.; Castaner, J.; Garcia-Capdevila, L. Celgosivir. Drugs Future 2005, 30, 545-52.
81. Whitby, K.; Taylor, D.; Patel, D.; Ahmed, P.; Tyms, A. S. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir. Chem. Chemother. 2004, 15, 141-51.
82. Hashimoto, Y. Thalidomide as a multi-template for development of biologically active compounds. Arch. Pharm. (Weinheim) 2008, 341, 536-47.
83. Noguchi-Yachide, T.; Aoyama, A.; Makishima, M.; Miyachi, H.; Hashimoto, Y. Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg. Med. Chem. Lett. 2007, 17, 3957-3961.
84. Noguchi-Yachide, T.; Miyachi, H.; Aoyama, H.; Aoyama, A.; Makishima, M.; Hashimoto, Y. Structural Development of Liver X Receptor (LXR) Antagonists Derived from Thalidomide-Related Glucosidase Inhibitors. Chem. Pharm. Bull. 2007, 55, 1750-1754.
85. Dodo, K.; Aoyama, A.; Noguchi-Yachide, T.; Makishima, M.; Miyachi, H.; Hashimoto, Y. Co-existence of a-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg. Med. Chem. 2008, 16, 4272-4285.
86. Baba, C.; Yanagida, K.; Kanzaki, T.; Baba, M. Colorimetric lactate dehydrogenase (LDH) assay for evaluation of antiviral activity against bovine viral diarrhoea virus (BVDV) in vitro. Antivir. Chem. Chemother. 2005, 16, 33-9.
87. Yanagida, K.; Baba, C.; Baba, M. Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-a Antiviral. Res. 2004, 64, 195-201.
88. Hosoda, S.; Tanatani, A.; Wakabayashi, K.; Makishima, M.; Imai, K.; Miyachi, H.; Nagasawa, K.; Hashimoto, Y. Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation. Bioorg. Med. Chem. 2006, 14, 5489-502.
89. Hosoda, S.; Aoyama, H.; Goto, Y.; Salim, M. T.; Okamoto, M.; Hashimoto, M.; Baba, M.; Hashimoto, Y. Discovery of diphen-ylmethane analogs as anti-bovine diarrhea viral agents. Bioorg. Med. Chem. Lett. 2009, 19, 3157-61.
90. Ruffa, M. P., M; Alfonso, V; Wagner, ML; Suriano, M; Vicente, C; Campos, R; Cavallaro, L. Antiviral activity of Petiveria alliacea against the bovine viral diarrhea virus. Chemotherapy 2002, 48, 144-147.
91. Bhattacharyaa, R. B., S; Wenzel-Mathers, M.; Buckwold, V. Phyl-lanthus amarus root clone with significant activity against bovine viral diarrhoea virus a surrogate model of hepatitis C virus. Curr. Sci. 2003, 84, 529-533.