Co-existence of α-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4272-4285

  Dodo, Kosuke ^a   Aoyama, Atsushi ^a   Noguchi Yachide, Tomomi ^a   Makishima, Makoto ^b   Miyachi, Hiroyuki ^a   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antagonist; Glucosidase; Inhibitor; Liver X receptor; Structural development

Indexed keywords

1 DEOXYNOJIRIMYCIN; 12 DEHYDROXYRICCARDIN C; 12,17 DEHYDROXYRICCARDIN C; 17 DEHYDROXYRICCARDIN C; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; 4 DEHYDROXYRICCARDIN C; 4,12,17 DEHYDROXYRICCARDIN C; 4,17 DEHYDROXYRICCARDIN C; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; GENISTEIN; HYDROXYCHOLESTEROL; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PP 2P; PP 60; PPS 33; RICCARDIN C; RICCARDIN C DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

ALDEHYDES; ALPHA-GLUCOSIDASES; CELL LINE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42149184935     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.078     Document Type: Article

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