Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers

Journal of Virology

Volumn 75, Issue 8, 2001, Pages 3527-3536

  Branza Nichita, N ^a   Durantel, D ^a   Carrouee Durantel S ^a   Dwek, R A ^a   Zitzmann, N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; DIMER; ENVELOPE PROTEIN; GLYCOPROTEIN; MIGLUSTAT;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BOVINE DIARRHEA VIRUS; CONTROLLED STUDY; DISSOCIATION; DISULFIDE BOND; DOSE RESPONSE; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; VIRUS INHIBITION;

1-DEOXYNOJIRIMYCIN; ALPHA-GLUCOSIDASES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; CALCIUM-BINDING PROTEINS; CALNEXIN; CALRETICULIN; CELL LINE; DIARRHEA VIRUSES, BOVINE VIRAL; DIMERIZATION; DISULFIDES; DOGS; GLYCOPROTEINS; HEPACIVIRUS; KINETICS; PLAQUE ASSAY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBONUCLEOPROTEINS; VIRAL ENVELOPE PROTEINS;

EID: 0035079046     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.8.3527-3536.2001     Document Type: Article

References (32)

1. Mechanism of action of a pestivirus antiviral compound
2. Calnexin: A membrane-bound chaperone of the endoplasmic reticulum
3. Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin
4. Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum
5. Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins
6. α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphoogenesis in the endoplasmic reticulum
7. Formation of native hepatitis C virus glycoprotein complexes
8. Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses
9. Hepatitis C virus glycoprotein folding: Disulfide bond formation and association with calnexin
10. Processing in the pestivirus E2-NS2 region: Identification of proteins p7 and E2p7
11. N-Butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120
12. Expression and identification of hepatitis C virus polyprotein cleavage products
13. E2-p7 region of the bovine viral diarrhea virus polyprotein: Processing and functional studies
14. Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum
15. Calnexin and BiP act as sequential molecular chaperones during tyroglobulin folding in the endoplasmic reticulum
16. Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
17. Prolonged association of temperature sensitive mutants of human P-glycoprotein with calnexin during biogenesis
18. Evidence that N-linked glycosylation is necessary for hepatitis B virus secretion
19. Role of carbohydrate processing and calnexin binding in the folding and activity of the HN protein of Newcastle disease virus
20. The molecular chaperone calnexin interacts with the NSP4 enterotoxin of rotavirus in vivo and in vitro
21. Mature, cell-associated HN protein of Newcastle disease exists in two forms differentiated by posttranslational modifications
22. Calnexin fails to associate with substrate proteins in glucosidase-deficient cell lines
23. Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoprotein
24. Flaviviridae: The viruses and their replication
25. N-linked oligosaccharides are necessary and sufficient for association for glycosylated forms of bovine RNase with calnexin and calreticulin
26. Hog cholera virus: Molecular composition of virions from a pestivirus
27. Calnexin associates exclusively with individual CD3d and T cell antigen receptor (TCR), a protein containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexes
28. Pestivirus glycoprotein which induces neutralizing antibodies forms part of a disulfide-linked heterodimer
29. Role for calnexin and N-linked glycosylation in the assembly and secretion of hepatitis B virus middle envelope protein particles
30. Formation of intracellular particles by hepatitis B virus large surface protein
31. Conformation-independent binding of monoglucosylated ribonuclease B to calnexin
32. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents