Antineoplastic effects of gamma linolenic acid on hepatocellular carcinoma cell lines

Journal of Clinical Biochemistry and Nutrition

Volumn 47, Issue 1, 2010, Pages 81-90

  Itoh, Shinji ^a   Taketomi, Akinobu ^a   Harimoto, Norifumi ^a   Tsujita, Eiji ^a   Rikimaru, Tatsuya ^a   Shirabe, Ken ^a   Shimada, Mitsuo ^b   Maehara, Yoshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Gamma linolenic acid; Heme oxygenase 1; Hepatocellular carcinoma; Oxidant stress

Indexed keywords

ADIPOPHILIN; BETA ACTIN; BETA N ACETYLHEXOSAMINIDASE; BETA2 GLYCOPROTEIN 1; CERAMIDASE; CLATHRIN; COMPLEMENTARY DNA; FERRITIN; G PROTEIN COUPLED RECEPTOR KINASE 5; GAMMA LINOLENIC ACID; HEME OXYGENASE 1; KYNURENINASE; MESOPORPHYRIN; METALLOTHIONEIN I; PROTEIN S 100; REACTIVE OXYGEN METABOLITE; STROMELYSIN 3; THIOREDOXIN; THIOREDOXIN REDUCTASE 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; DRUG POTENTIATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER CELL CARCINOMA; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; WESTERN BLOTTING;

EID: 77955609166     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.10-24     Document Type: Article

References (33)

1. Jiang, W.G., Bryce, R.P., and Horrobin, D.F.: Essential fatty acid: molecular and cellular basis of their anticancer action and clinical implications. Crit. Rev. Oncol. Hematol., 27, 179-209, 1998.
2. Fearon, K.C., Falconer, J.S., Ross, J.A., Carter, D.C., Hunter, J.O., Reynolds, P.D., and Tuffnell, Q.: An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gamma linolenate. Anticancer Res., 16, 867-874, 1996.
3. Kenny, F.S., Pinder, S.E., Ellis, I.O., Gee, J.M., Nicholson, R.I., Bryce, R.P., and Robertson, J.F.: Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Int. J. Cancer, 85, 643-648, 2000.
4. Ells, G.W., Chisholm, K.A., Simmons, V.A., and Horrobin, D.F.: Vitamin E blocks the cytotoxic effect of γ-linolenic acid when administered as late as the time of onset of cell death - insight into the mechanism of fatty acid induced cytotoxicity. Cancer Lett., 98, 207-211, 1996.
5. Das, U.N.: From bench to the clinic: gamma-linolenic acid therapy of human gliomas. Prostaglandins Leukot. Essent. Fatty Acids, 70, 539-552, 2004.
6. Das, U.N.: Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. Med. Sci. Monit., 13, 119-131, 2007.
7. Hayashi, Y., Fukushima, S., Hirata, T., Kishimoto, S., Katsuki, T., and Nakano, M.: Anticancer activity of free gamma-linolenic acid on AH-109A rat hepatoma cells and the effect of serum albumin on anticancer activity of gamma-linolenic acid in vitro. J. Pharmacobiodyn., 11, 705-711, 1990.
8. Ross, D.T., Scherf, U., Eisen, M.B., Perou, C.M., Rees, C., Spellman, P., Iyer, V., Jeffrey, S.S., Van de Rijn, M., Waltham, M., Pergamenschikov, A., Lee, J.C., Lashkari, D., Shalon, D., Myers, T.G., Weinstein, J.N., Botstein, D., and Brown, P.O.: Systematic variation in gene expression patterns in human cancer cell lines. Nat. Genet., 24, 227-235, 2000.
9. Scherf, U., Ross, D.T., Waltham, M., Smith, L.H., Lee, J.K., Tanabe, L., Kohn, K.W., Reinhold, W.C., Myers, T.G., Andrews, D.T., Scudiero, D.A., Eisen, M.B., Sausville, E.A., Pommier, Y., Botstein, D., Brown, P.O., and Weinstein, J.N.: A gene expression detabase for the molecular pharmacology of cancer. Nat. Genet., 24, 236-244, 2000.
10. van Wezel, A.L.: Growth of cell-strains and primary cells on microcarriers in homogeneous culture. Nature, 216, 64-65, 1967.
11. Maehara, S.-I., Tanaka, S., Shimada, M., Shirabe, K., Saito, Y., Takahashi, K., and Maehara, Y.: Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells. Int. J. Cancer, 112, 184-189, 2004.
12. Niehaus, W.G. and Samuelsson, B.: Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur. J. Biochem., 6, 126-130, 1968.
13. Bai, J., Rodriguez, A.M., Melendez, J.A., and Cederbaum, A.I.: Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury. J. Biol. Chem., 274, 26217-26224, 1999.
14. Ohuchida, T., Okamoto, K., Akahane, K., Higure, A., Todoroki, H., Abe, Y., Kikuchi, M., Ikematsu, S., Muramatsu, T., and Itoh, H.: Midkine protects hepatocellular carcinoma cells against TRAIL mediated apoptosis through downregulation of caspase-3 activity. Cancer, 100, 2430-2436, 2004.
15. Andoh, T., Chock, P.B., and Chiueh, C.C.: The role of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells. J. Biol. Chem., 277, 9655-9660, 2002.
16. Lapillonne, H., Konopleva, M., Tsao, T., Gold, D., McQueen, T., Sutherland, R.L., Madden, T., and Andreeff, M.: Activation of peroxisome proliferator activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells. Cancer Res., 63, 5926-5939, 2003.
17. Itoh, S., Maeda, T., Shimada, M., Aishima, S.-I., Shirabe, K., Tanaka, S., and Maehara, Y.: Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin. Cancer Res., 10, 2812-2817, 2004.
18. Vartak, S., McCaw, R., Davis, C.S., Robbins, M.E., and Spector, A.A.: Gamma linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. Br. J. Cancer, 77, 1612-1620, 1998.
19. Colquhoun, A. and Schumacher, R.I.: gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. Biochem. Biophys. Acta, 1533, 207-219, 2001.
20. Vreman, H.J., Ekstrand, B.C., and Stevenson, D.K.: Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr. Res., 33, 195-200, 1993.
21. Cocco, T., Di Paola, M., Papa, S., and Lorusso, M.: Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species. Free Radic. Biol. Med., 27, 51-59, 1999.
22. Ricciarelli, R., Zingg, J.M., and Azzi, A.: Vitamin E: protective role a Janus molecule. FASEB J., 15, 2314-2325, 2001.
23. Kantrow, S.P., Tatro, L.G., and Piantadosi, C.A.: Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. Free Radic. Biol. Med., 28, 251-260, 2000.
24. Kim, C.N., Way, X., Huang, Y., Ibrado, A.M., Liu, L., Fang, G., and Bhalla, K.: Overexpression of Bcl-xL inhibits ara-c induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res., 57, 3115-3120, 1997. (Pubitemid 27351721)
25. Choi, A.M. and Alam, J.: Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol., 15, 9-19, 1996.
26. Otterbein, L.E., Bach, F.H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R.J., Flavell, R.A., and Choi, A.M.: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat. Med., 6, 422-428, 2000.
27. Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N., and Ames, B.N.: Bilirubin is an antioxidant of possible physiological importance. Science, 235, 1043-1046, 1987.
28. Llesuy, S.F. and Tomaro, M.L.: Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochem Biophys. Acta, 1223, 9-14, 1994.
29. Mustacich, D. and Powis, G.: Thioredoxin reductase. Biochem. J., 346, 1-8, 2000.
30. Smart, D.K., Ortiz, K.L., Mattson, D., Bradbury, C.M., Bisht, K.S., Sieck, L.K., Brechbiel, M.W., and Gius, D.: Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress. Cancer Res., 64, 6716-6724, 2004.
31. Lin, H.K., Jez, J.M., Schlegel, B.P., Peehl, D.M., Pachter, J.A., and Penning, T.M.: Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. Mol. Endocrinol., 11, 1971-1984, 1997.
32. Penning, T.M., Burczynski, M.E., Jez, J.M., Hung, C.F., Lin, H.K., Ma, H., Moore, M., Palackal, N., and Ratnam, K.: Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem. J., 351, 67-77, 2000.
33. Burczynski, M.E., Sridhar, G.R., Palackal, N.T., and Penning, T.M.: The reactive oxygen species - and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. J. Biol. Chem., 276, 2890-2897, 2001.