Molecular mechanisms of general anesthesia

Korean Journal of Anesthesiology

Volumn 59, Issue 1, 2010, Pages 3-8

  Son, Yong ^a  

^a Wonkwang University School of Medicine   (South Korea)

Author keywords

GABAA receptors; General anesthetics; Neurotransmitter gated ion channels

Indexed keywords

2 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALANINE; GLUTAMATE RECEPTOR; GLYCINE RECEPTOR; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID; NEUROTRANSMITTER; NICOTINIC RECEPTOR; POTASSIUM CHANNEL; SERINE; SEROTONIN RECEPTOR; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

AMNESIA; ANESTHESIA MECHANISM; ANTICONVULSANT ACTIVITY; BINDING AFFINITY; CELL FUNCTION; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; DRUG MECHANISM; DRUG TARGETING; ELECTRIC ACTIVITY; GENERAL ANESTHESIA; HUMAN; HYPERPOLARIZATION; HYPNOSIS; HYPOTHALAMUS; MUSCLE RELAXATION; NEOCORTEX; NERVE CELL EXCITABILITY; NERVE CONDUCTION; POSTSYNAPTIC POTENTIAL; REVIEW; SEDATION; SPINAL REFLEX; THALAMUS; TRANQUILIZING ACTIVITY;

EID: 77955593330     PISSN: 20056419     EISSN: 20057563     Source Type: Journal    
DOI: 10.4097/kjae.2010.59.1.3     Document Type: Review

References (48)

1. Campagna JA, Miller KW, Forman SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med 2003; 348: 2110-24.
2. Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci 2005; 26: 503-10.
3. Orser BA, Canning KJ, Macdonald JF. Mechanisms of general anesthesia. Curr Opin Anaesthesiol 2002; 15: 427-33.
4. Franks NP. Molecular targets underlying general anaesthesia. Br J Pharmacol 2006; 147 Suppl 1: S72-81.
5. Hemmings HC Jr. Sodium channels and the synaptic mechanisms of inhaled anaesthetics. Br J Anaesth 2009; 103: 61-9.
6. Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, et al. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg 2003; 97: 718-40.
7. A receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. J Neurosci 2006; 26: 3713-20.
8. Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, et al. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. J Neurosci 2004; 24: 8454-8.
9. A-receptor subtypes really occur in the brain? Trends Neurosci 1996; 19: 139-43.
10. Krogsgaard-Larsen P, Frolund B, Liljefors T, Ebert B. GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochem Pharmacol 2004; 68: 1573-80.
11. A receptors. In: Neural Mechanisms of Anesthesia. Edited by Antognini JF, Carstens EE, Raines DE: New Jersey, Humana Press. 2003, pp 265-82.
12. Franks NP, Honore E. The TREK K2P channels and their role in general anaesthesia and neuroprotection. Trends Pharmacol Sci 2004; 25: 601-8.
13. Ouyang W, Wang G, Hemmings HC Jr. Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Mol Pharmacol 2003; 64: 373-81.
14. Kamatchi GL, Chan CK, Snutch T, Durieux ME, Lynch C 3rd. Volatile anesthetic inhibition of neuronal Ca channel currents expressed in Xenopus oocytes. Brain Res 1999; 831: 85-96.
15. Bloom FE, Iversen LL. Localizing 3H-GABA in nerve terminals of rat cerebral cortex by electron microscopic autoradiography. Nature 1971; 229: 628-30.
16. A receptor channels. Annu Rev Neurosci 1994; 17: 569-602.
17. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, et al. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev 1998; 50: 291-313.
18. A receptors open? Neuron 1994; 12: 61-71.
19. A receptors: modulating gain and maintaining the tone. Trends Neurosci 2004; 27: 262-9.
20. A receptors. J Physiol 1996; 497: 753-9.
21. A receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Mol Pharmacol 2003; 63: 2-8.
22. Bai D, Pennefather PS, MacDonald JF, Orser BA. The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. J Neurosci 1999; 19: 10635-46.
23. Bai D, Zhu G, Pennefather P, Jackson MF, MacDonald JF, Orser BA. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Mol Pharmacol 2001; 59: 814-24.
24. Nusser Z, Mody I. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J Neurophysiol 2002; 87: 2624-8.
25. Stell BM, Mody I. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. J Neurosci 2002; 22: RC223.
26. Glykys J, Mody I. The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol 2007; 582: 1163-78.
27. A receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons. J Neurophysiol 2007; 98: 2244-54.
28. Orser BA, McAdam LC, Roder S, MacDonald JF. General anaesthetics and their effects on GABA(A) receptor desensitization. Toxicol Lett 1998; 100-101: 217-24.
29. A receptors in cultured murine hippocampal neurons. J Neurosci 1994; 14: 7747-60.
30. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, et al. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 1997; 389: 385-9.
31. Siegwart R, Jurd R, Rudolph U. Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3) gamma(2)gamma-aminobutyric acid(A) receptors. J Neurochem 2002; 80: 140-8.
32. Pain L, Angst MJ, LeGourrier L, Oberling P. Effect of a nonsedative dose of propofol on memory for aversively loaded information in rats. Anesthesiology 2002; 97: 447-53.
33. A conductances in anesthetic suppression of intrinsic neuronal excitability. J Neurophysiol 2004; 92: 1658-67.
34. Wainwright A, Sirinathsinghji DJ, Oliver KR. Expression of GABA(A) receptor alpha5 subunit-like immunoreactivity in human hippocampus. Brain Res Mol Brain Res 2000; 80: 228-32.
35. A receptors in rat brain. Brain Res 1999; 822: 265-70.
36. A receptor. J Neurosci 2002; 22: 5572-80.
37. Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, et al. Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors. Proc Natl Acad Sci U S A 2002; 99: 8980-5.
38. Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 2004; 5: 709-20.
39. Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, et al. Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci 2003; 23: 8608-17.
40. Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, et al. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 1999; 401: 796-800.
41. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, et al. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J 2003; 17: 250-2.
42. A receptors of thalamocortical neurons: a molecular target for hypnotics. J Neurosci 2005; 25: 11513-20.
43. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci 2002; 5: 979-84.
44. Ouyang W, Hemmings HC Jr. Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals. J Pharmacol Exp Ther 2005; 312: 801-8.
45. Flood P, Ramirez-Latorre J, Role L. Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected. Anesthesiology 1997; 86: 859-65.
46. Lin LH, Chen LL, Harris RA. Enflurane inhibits NMDA, AMPA, and kainate-induced currents in Xenopus oocytes expressing mouse and human brain mRNA. FASEB J 1993; 7: 479-85.
47. Maclver MB, Mikulec AA, Amagasu SM, Monroe FA. Volatile anesthetics depress glutamate transmission via presynaptic actions. Anesthesiology 1996; 85: 823-34.
48. + channels. Nat Neurosci 1999; 2: 422-6.