Expression of GABA(A) receptor α5 subunit-like immunoreactivity in human hippocampus

Molecular Brain Research

Volumn 80, Issue 2, 2000, Pages 228-232

  Wainwright, A ^a   Sirinathsinghji, D J S ^a   Oliver, K R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

GABA(A); Hippocampal formation; Human brain; Immunohistochemisty

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; GABAERGIC SYSTEM; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; RATS; RECEPTORS, GABA-A;

HIPPOCAMPUS HIPPOCAMPUS;

EID: 0034665812     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00133-9     Document Type: Article

References (32)

1. Amaral D.G., Insausti R. Hippocampal formation. Paxinos G. The Human Nervous System. 1990;711-756 Academic Press, New York, USA.
2. Araujo F., Ruano D., Vitorica J. Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both α1 and α5 subunits, exhibit a single benzodiazepine binding site with α5 pharmacological properties. J. Pharm. Exp. Ther. 290:1999;989-997.
3. Baude A., Sequier J.M., McKernan R.M., Oliver K.R., Somogyi P. Differential subcellular distribution of the α6 subunit versus the α1 and β2/3 subunits of the GABA(A)/benzodiazepine receptor complex in granule cells of the cerebellar cortex. Neuroscience. 51:1992;739-748.
4. Brown T.H., Zador A.M. Hippocampus. Shepherd G.M. The Synaptic Organization of the Brain. 1990;346-388 Oxford University Press, Oxford.
5. Burgard E.C., Tietz E.I., Neelands T.R., Macdonald R.L. Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the α5 subunit subtype. Mol. Pharmacol. 50:1996;119-127.
6. A receptor subunit (α1, α2, α3, α5, β2, β3) immunoreactivity in the medial prefrontal cortex of the rat. Neuroscience Letts. 210:1996;213-217.
7. A-receptor α-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience. 81:1997;1043-1053.
8. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. Comp. Neurol. 359:1995;154-194.
9. Kaupmann K., Huggel K., Heid J., Flor P.J., Bischoff S., Mickel S.J., McMaster G., Angst C., Bittiger H., Froestl W., Bettler B. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
10. Liu Z.F., Kamatchi G.L., Moreira T., Mu W., Burt D.R. The α5 subunit of the murine type A GABA receptor. Mol. Brain Res. 59:1998;84-89.
11. A receptor in rat brain. FEBS. Lett. 260:1990;261-265.
12. A receptors. Brain Res. Rev. 29:1999;196-217.
13. A-receptor subtypes differing in α-subunit composition display unique pharmacological properties. Adv. Biochem. Psychopharm. 47:1992;41-53.
14. Mohler H., Okada T. Benzodiazepine receptor: demonstration in the central nervous system. Science. 198:1977;849-851.
15. Nicoll R.A. The coupling of neurotransmitter receptors to ion channels in the brain. Science. 241:1988;545-551.
16. B inhibitory postsynaptic responses originate from distinct interneurons in the hippocampus? Can. J. Physiol. Pharmacol. 75:1997;520-525.
17. Oliver K.R., Wainwright A., Heavens R.P., Sirinathsinghji D.J.S. Retrieval of cellular mRNA in paraffin-embedded human brain using hydrated autoclaving. J. Neurosci. Methods. 77:1997;169-174.
18. A-benzodiazepine receptors produced in transfected cells. Science. 245:1989;1389-1392.
19. A receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 54:1990;1802-1804.
20. Roberts E. GABA: the road to neurotransmitter status. Olsen R.W., Venter J.C. Benzodiazepine/gaba Receptors and Chloride Channels: Structural and Functional Properties. 1986;1-39 Liss, New York.
21. A receptor subtypes. Pharmacol. Revs. 47:1995;181-234.
22. Sieghart W., Fuchs K., Tretter V., Ebert V., Jechlinger M., Hoger H., Adamiker D. Structure and subunit composition of GABA(A) receptors. Neurochem. Int. 34:1999;379-385.
23. Sloviter R.S., Ali A.L., Elliott R.C., Bowery B.J., Bowery N.G. Localization of GABA(B) (R1) receptors in the rat hippocampus by immunocytochemistry and high resolution autoradiography, with specific reference to its localization in identified hippocampal interneuron subpopulations. Neuropharmacology. 38:1999;1707-1721.
24. Sperk G., Schwarzer C., Tsunashima K., Fuchs K., Sieghart W. GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience. 80:1997;987-1000.
25. Squires R.F., Brastrup C. Benzodiazepine receptors in rat brain. Nature. 266:1977;732-734.
26. A receptors in rat brain. Brain Res. 822:1999;265-270.
27. A receptor α5 and α6 subunit-like immunoreactivity in rat brain. Neuroscience. 144:1992;53-56.
28. Whiting P.J. The GABA-A receptor gene family: new targets for therapeutic intervention. Neurochem. Int. 34:1999;387-390.
29. Whiting P.J., Bonnert T.P., McKernan R.M., Farrar S., Le-Bourdelles B., Heavens R.P., Smith D.W., Hewson L., Rigby M.R., Sirinathsinghji D.J.S., Thompson S.A., Wafford K.A. Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann. NY Acad. Sci. 868:1999;645-653.
30. A receptor subtypes. Int. Rev. Neurobiol. 38:1995;95-138.
31. Wingrove P., Hadingham K., Wafford K., Kemp J.A., Ragan C.I., Whiting P. Cloning and expression of a cDNA encoding the human GABA-A receptor α5 subunit. Biochem. Soc. Trans. 20:1992;18S.
32. A receptor subunit mRNAs in the rat brain - I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12:1992;1040-1062.