Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats

Journal of Neuroscience

Volumn 28, Issue 39, 2008, Pages 9702-9709

  DiPatrizio, Nicholas V ^a   Simansky, Kenny J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Brainstem; Cannabinoids; CB1 receptor; Eating; Feeding; Opioid; Parabrachial; Reward

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; ENDOCANNABINOID 2 ARACHIDONOYL GLYCEROL; GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; SUCROSE; UNCLASSIFIED DRUG; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 2 ARACHIDONOYLGLYCEROL; 2-ARACHIDONYLGLYCEROL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; CONNECTIVE TISSUE ACTIVATING PEPTIDE; CONNECTIVE TISSUE-ACTIVATING PEPTIDE; ENDOCANNABINOID; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NARCOTIC ANTAGONIST; PEPTIDE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; SULFUR; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; EATING; ENERGY BALANCE; FEEDING; FOOD INTAKE; FUNCTIONAL STATUS; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIPID DIET; MALE; NEUROTRANSMISSION; NONHUMAN; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; RAT; TASTE; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FOOD PREFERENCE; INSTRUMENTAL CONDITIONING; METABOLISM; METHODOLOGY; PHYSIOLOGY; PONS; SPRAGUE DAWLEY RAT; TIME;

ANALYSIS OF VARIANCE; ANIMALS; ARACHIDONIC ACIDS; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; EATING; ENDOCANNABINOIDS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FOOD PREFERENCES; GLYCERIDES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; NARCOTIC ANTAGONISTS; PEPTIDES; PIPERIDINES; PONS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTORS, OPIOID, MU; SULFUR ISOTOPES; TIME FACTORS; XANTHINES;

EID: 55749101589     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1171-08.2008     Document Type: Article

References (45)

1. Anderson-Baker WC, McLaughlin CL, Baile CA (1979) Oral and hypothalamic injections of barbiturates, benzodiazepines and cannabinoids and food intake in rats. Pharmacol Biochem Behav 11:487-491.
2. Arnone M, Maruani J, Chaperon F, Thiébot MH, Poncelet M, Soubrié P, Le Fur G (1997) Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology 132:104-106.
3. Burdyga G, Lal S, Varro A, Dimaline R, Thompson DG, Dockray GJ (2004) Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 24:2708-2715.
4. Colombo G, Agabio R, Diaz G, Lobina C, Reali R, Gessa GL (1998) Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci 63:PL113-PL117.
5. Contreras RJ, Beckstead RM, Norgren R (1982) The central projections of the trigeminal, facial, glossopharyngeal and vagus nerves: an autoradiographic study in the rat. J Auton Nerv Syst 6:303-322.
6. Cota D, Tschöp MH, Horvath TL, Levine AS (2006) Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev 51:85-107.
7. Devane WA, Dysarz FA 3rd, Johnson MR, Melvin LS, Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613.
8. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949.
9. Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410:822-825.
10. Gómez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodríguez de Fonseca F (2002) A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 22:9612-9617.
11. Hajnal A, Norgren R (2005) Taste pathways that mediate accumbens dopamine release by sapid sucrose. Physiol Behav 84:363-369.
12. Hamilton RB, Norgren R (1984) Central projections of gustatory nerves in the rat. J Comp Neurol 222:560-577.
13. Herbert H, Moga MM, Saper CB (1990) Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 293:540-580.
14. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11:563-583.
15. Jamshidi N, Taylor DA (2001) Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol 134:1151-1154.
16. Karimnamazi H, Travers JB (1998) Differential projections from gustatory responsive regions of the parabrachial nucleus to the medulla and forebrain. Brain Res 813:283-302.
17. Karimnamazi H, Travers SP, Travers JB (2002) Oral and gastric input to the parabrachial nucleus of the rat. Brain Res 957:193-206.
18. Kelley AE, Baldo BA, Pratt WE, Will MJ (2005) Corticostriatal- hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86:773-795.
19. Kirkham TC, Williams CM, Fezza F, Di Marzo V (2002) Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 136:550-557.
20. Koch JE, Matthews SM (2001) Delta9-tetrahydrocannabinol stimulates palatable food intake in Lewis rats: effects of peripheral and central administration. Nutr Neurosci 4:179-187.
21. Mailleux P, Vanderhaeghen JJ (1992) Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48:655-668.
22. Matias I, Di Marzo V (2007) Endocannabinoids and the control of energy balance. Trends Endocrinol Metab 18:27-37.
23. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, Pertwee RG, Griffin G, Bayewitch M, Barg J, Vogel Z (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83-90.
24. Miller CC, Murray TF, Freeman KG, Edwards GL (2004) Cannabinoid agonist, CP 55,940, facilitates intake of palatable foods when injected into the hindbrain. Physiol Behav 80:611-616.
25. Moga MM, Herbert H, Hurley KM, Yasui Y, Gray TS, Saper CB (1990) Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat. J Comp Neurol 295:624-661.
26. Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65.
27. Nicklous DM, Simansky KJ (2003) Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake. Am J Physiol Regul Integr Comp Physiol 285:R1046-R1054.
28. Norgren R (1974) Gustatory afferents to ventral forebrain. Brain Res 81:285-295.
29. Norgren R (1976) Taste pathways to hypothalamus and amygdala. J Comp Neurol 166:17-30.
30. Norgren R, Leonard CM (1971) Taste pathways in rat brainstem. Science 173:1136-1139.
31. Norgren R, Pfaffmann C (1975) The pontine taste area in the rat. Brain Res 91:99-117.
32. Norgren R, Hajnal A, Mungarndee SS (2006) Gustatory reward and the nucleus accumbens. Physiol Behav 89:531-535.
33. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. San Diego: Academic.
34. Pertwee RG (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76:1307-1324.
35. Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873-884.
36. Savinainen JR, Järvinen T, Laine K, Laitinen JT (2001) Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes. Br J Pharmacol 134:664-672.
37. Savinainen JR, Saario SM, Niemi R, Järvinen T, Laitinen JT (2003) An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors. Br J Pharmacol 140:1451-1459.
38. Simansky KJ, Nicklous DM (2002) Parabrachial infusion of D-fenfluramine reduces food intake. Blockade by the 5-HT(1B) antagonist SB-216641. Pharmacol Biochem Behav 71:681-690.
39. Soria-Gómez E, Matias I, Rueda-Orozco PE, Cisneros M, Petrosino S, Navarro L, Di Marzo V, Prospéro-García O (2007) Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. Br J Pharmacol 151:1109-1116.
40. Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K (1995) 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 215:89-97.
41. Verty AN, McGregor IS, Mallet PE (2005) Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol. Neuropharmacology 49:1101-1109.
42. Ward HG, Simansky KJ (2006) Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food. Psychopharmacology 187:435-446.
43. Ward HG, Nicklous DM, Aloyo VJ, Simansky KJ (2006) Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating. Eur J Neurosci 23:1605-1613.
44. Williams CM, Kirkham TC (2002) Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine. Pharmacol Biochem Behav 71:333-340.
45. Wilson JD, Nicklous DM, Aloyo VJ, Simansky KJ (2003) An orexigenic role for mu-opioid receptors in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol 285:R1055-R1065.