Conformations, conformational preferences, and conformational exchange of N′-substituted N -acylguanidines: Intermolecular interactions hold the key

Journal of the American Chemical Society

Volumn 132, Issue 32, 2010, Pages 11223-11233

  Kleinmaier, Roland ^a   Keller, Max ^a   Igel, Patrick ^a   Buschauer, Armin ^a   Gschwind, Ruth M ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACCEPTOR PROPERTIES; ALKYL SUBSTITUENT; AS-LIGANDS; BIOISOSTERES; BIOLOGICAL TARGETS; BIOLOGICALLY ACTIVE COMPOUNDS; BISPHOSPHONATES; CONFORMATIONAL EXCHANGE; CONFORMATIONAL PREFERENCES; EXCHANGE RATES; G PROTEIN COUPLED RECEPTORS; INTERMOLECULAR INTERACTIONS; LIGAND-RECEPTOR INTERACTIONS; MECHANISM OF ACTION; MICROSOLVATION; MOLECULAR BASIS; MOLECULAR LEVELS; PHARMACOKINETICS AND PHARMACODYNAMICS; PROTONATED; RATIONAL DESIGN; SOLVENT MOLECULES; STRUCTURAL FEATURE;

BIOMIMETICS; HYDROCARBONS; LIGANDS; MACHINE DESIGN; NEGATIVE IONS;

CONFORMATIONS;

DIMETHYL SULFOXIDE; G PROTEIN COUPLED RECEPTOR; GUANIDINE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG STRUCTURE; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE;

ALKANES; CRYSTALLOGRAPHY, X-RAY; DIMETHYL SULFOXIDE; GUANIDINES; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITROGEN; PHOSPHONIC ACIDS; PROTONS; SOLVENTS;

EID: 77955561472     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103756y     Document Type: Article

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