Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 4280-4287

  He, Guijia ^a   Dou, Dengfeng ^a   Wei, Liuqing ^a   Alliston, Kevin R ^a   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

Author keywords

Neutrophil elastase; Protease inhibitors

Indexed keywords

1 (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YL) 3 PHENETHYLUREA; 1 (3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YL)3 PHENETHYLUREA; 1 (4 BENZYL 5 OXOIMIDAZOLIDIN 1 YL) 3 PHENETHYLUREA; 1 BENZYL N (4 BENZYL 5 OXOIMIDAZOLIDIN 1 YL) 5 OXOPYRROLIDINE 3 CARBOXAMIDE; 1 BENZYL N(3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YL) 5 OXOPYRROLIDINE 3 CARBOXAMIDE; 2 (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YLCARBAMOYL)BENZOIC ACID; 2 (3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YLCARBAMOYL)BENZOIC ACID; 2 (4 BENZYL 5 OXOIMIDAZOLIDIN 1 YLCARBAMOYL)BENZOIC ACID; 3 AMINO 1,5 DIBENZYLIMIDAZOLIDIN 4 ONE; 4 (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YLAMINO) 4 OXOBUTANOIC ACID; 4 (3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YLAMINO) 4 OXOBUTANOIC ACID; 4 (4 BENZYL 5 OXOIMIDAZOLIDIN 1 YLAMINO) 4 OXOBUTANOIC ACID; BENZYL 1 (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YLAMINO) 1 OXO 3 PHENYL PROPAN 2 YLCARBAMATE; ETHYL 2 (3 (3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YL)UREIDO)ACETATE; ETHYL 2 [3 (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YL)UREIDO]ACETATE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; MYELOBLASTIN; N (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YL) 3 PHENYLPROPANAMIDE; N (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YL) 4 METHYL N TOSYLBENZENESULFONAMIDE; N (3 BENZYL 4 ISOBUTYL 5 OXOIMIDAZOLIDIN 1 YL) N (METHYLSULFONYL)METHANESULFONAMIDE; N (3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YL) 1 (FURAN 2 YLMETHYL) 5 OXOPYRROLIDINE 3 CARBOXAMIDE; N (4 BENZYL 5 OXOIMIDAZOLIDIN 1 YL) 1 (4 FLUOROBENZYL) 5 OXOPYRROLIDINE 3 CARBOXAMIDE; N AMINO 4 IMIDAZOLIDINONE; N(3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YL] 1 (4 FLUOROBENZYL) 5 OXOPYRROLIDINE 3 CARBOXAMIDE; TERT BUTYL 2 (2 (BENZYLAMINO) 3 PHENYLPROPANOYL)HYDRAZINECARBOXYLATE; TERT BUTYL 2 (2 (BENZYLOXYCARBONYLAMINO) 3 PHENYLPROPANOYL)HYDRAZINE CARBOXYLATE; TERT BUTYL 2 (2 AMINO 3 PHENYLPROPANOYL)HYDRAZINECARBOXYLATE; TERT BUTYL 3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YL(HYDROXYMETHYL)CARBAMATE; TERT BUTYL 3,4 DIBENZYL 5 OXOIMIDAZOLIDIN 1 YLCARBAMATE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL EVALUATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL;

DRUG DESIGN; HUMANS; IMIDAZOLIDINES; LEUKOCYTE ELASTASE; PROTEASE INHIBITORS;

EID: 77955555906     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.06.028     Document Type: Article

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