Inspection of the binding sites of proteinase3 for the design of a highly specific substrate

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1248-1260

  Hajjar, Eric ^a   Korkmaz, Brice ^b   Gauthier, Francis ^b   Brandsdal, Bjørn Olav ^c   Witko Sarsat, Véronique ^d   Reuter, Nathalie ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITÉ DE TOURS   (France)

^c UNIVERSITY OF TROMSØ   (Norway)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE; MYELOBLASTIN; PEPTIDE; PEPTIDE PB1; PEPTIDE PB22; PEPTIDE PNS; PEPTIDE POPT; PEPTIDE T PNS; PEPTIDE T PS; UNCLASSIFIED DRUG; VALYLALANYLASPARTYLVALYLLYSYLASPARTYLARGININE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG PROTEIN BINDING; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; NEUTROPHIL; PROTEIN PROTEIN INTERACTION; SIMULATION;

AMINO ACID SEQUENCE; BINDING SITES; CONSENSUS SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; LEUKOCYTE ELASTASE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYELOBLASTIN; OLIGOPEPTIDES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SOLVENTS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 33144464593     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051018t     Document Type: Article

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