Testing drugs in animal models of cigarette smoke-induced chronic obstructive pulmonary disease

Proceedings of the American Thoracic Society

Volumn 6, Issue 6, 2009, Pages 550-552

  Churg, Andrew ^a   Wright, Joanne L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Animal models; Cigarette smoke; Emphysema; Pulmonary hypertension; Small airway remodeling

Indexed keywords

CIGARETTE SMOKE; COLLAGEN; ELASTIN; PHOSPHODIESTERASE IV INHIBITOR; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN LYSINE 6 OXIDASE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL MODEL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFERENCE PAPER; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFICACY; DRUG SCREENING; GENE EXPRESSION REGULATION; HUMAN; LUNG EMPHYSEMA; LUNG FUNCTION TEST; LUNG INJURY; NONHUMAN; PULMONARY HYPERTENSION; UPREGULATION;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMOKE; SMOKING;

EID: 70349091855     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200903-012DS     Document Type: Conference Paper

References (21)

1. Churg A, Cosio M, Wright JL. Mechanisms of cigarette smoke-induced COPD: insights from animal models. Am J Physiol Lung Cell Mol Physiol 2008;294:L612-L631.
2. Churg A, Tai H, Wright JL. Persisting upregulation of profibrotic mediators in the small airways but not the parenchyma after smoke exposure in the mouse [abstract]. Am J Respir Crit Care Med 2007; 175:A553.
3. Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2008;295:L1-L15.
4. Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T. Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. Am J Respir Cell Mol Biol 2008;39:400-411.
5. Maes T, Bracke KR, Vermaelen KY, Demedts IK, Joos GF, Pauwels RA, Brusselle GG. Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation. Int Arch Allergy Immunol 2006; 141:354-368. (Pubitemid 44783906)
6. Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL. Tumor necrosis factor-a drives 70-% of cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2004;170:492-498. (Pubitemid 39209129)
7. D'hulst AI, Bracke KR, Maes T, De Bleecker JL, Pauwels RA, Joos GF, Brusselle GG. Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema. Eur Respir J 2006;28:102-112.
8. Barnes PJ. Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:866-867. (Pubitemid 46684694)
9. Martorana PA, Beume R, Lucattelli M, Wollin L, Lungarella G. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005;172:848-853. (Pubitemid 41369068)
10. Lee J-H, Lee D-S, Kim E-K, Choe K-H, Oh Y-M, Shim T-S, Kim S-E, Lee Y-S, Lee S-D. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med 2005;172:987-993. (Pubitemid 41476535)
11. Søyseth V, Brekke PH, Smith P, Omland T. Statin use is associated with reduced mortality in COPD. Eur Respir J 2007;29:279-283. (Pubitemid 46237383)
12. Churg A, Wang R, Wang X, Onnervik P-O, Thim K, Wright JL. An MMP-9/-12 inhibitor prevents smoke-induced emphysema and airway remodeling in guinea pigs. Thorax 2007;62:706-713. (Pubitemid 47235016)
13. Churg A, Zhou S, Preobrazhenska O, Tai H, Wang R, Wright JL. Expression of profibrotic mediators in small airways vs parenchyma after cigarette smoke exposure. Am J Respir Cell Mol Biol 2009;40: 268-276.
14. Shiomi T, Okada Y, Foronjy R, Schiltz J, Jaenish R, Krane S, D'Armiento J. Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1. Exp Lung Res 2003;29:1-15. (Pubitemid 36021041)
15. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-2653. (Pubitemid 38787999)
16. Churg A, Zhou S, Wang X, Wang R, Wright JL. The role of interleukin- 1b in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 2009;40:482-490.
17. Bracke KR, D'hulst AI, Maes T, Moerloose KB, Demedts IK, Lebecque S, Joos GF, Brusselle GG. Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J Immunol 2006;177:4350-4359.
18. Bracke KR, D'hulst AI, Maes T, Demedts IK, Moerloose KB, Kuziel WA, Joos GF, Brusselle GG. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Clin Exp Allergy 2007;37: 1467-1479.
19. Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J 2008;32:1371-1384.
20. Elwing J, Panos RJ. Pulmonary hypertension associated with COPD. Int J Chron Obstruct Pulmon Dis 2008;3:55-70.
21. Wright JL, Levy RD, Churg A. Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax 2005;60:605-609. (Pubitemid 40966216)