Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S′ subsite binding

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3536-3542

  Li, Yi ^a   Dou, Dengfeng ^a   He, Guijia ^a   Lushington, Gerald H ^b   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Inhibitors; Proteases; Serine

Indexed keywords

LEUKOCYTE ELASTASE; MYELOBLASTIN; SERINE PROTEINASE INHIBITOR;

ARTICLE; BINDING SITE; CHEMICAL INTERACTION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MOLECULAR DOCKING;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; LEUKOCYTE ELASTASE; MYELOBLASTIN; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIADIAZOLES;

EID: 65349085669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.011     Document Type: Article

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