Identification of genes involved in gentamicin-induced nephrotoxicity in rats - A toxicogenomic investigation

Experimental and Toxicologic Pathology

Volumn 62, Issue 5, 2010, Pages 555-566

  Ozaki, N ^a   Matheis, K A ^b   Gamber, M ^b   Feidl, T ^b   Nolte, T ^b   Kalkuhl, A ^b   Deschl, U ^b  

^a NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

ATP6V1D; GATM; Gentamicin; Kidney; Kim 1; Microarray; Nephrotoxicity; Rat; Toxicogenomics; Transferrin receptor

Indexed keywords

GENTAMICIN; GLUCOSE; GLUCOSE 6 PHOSPHATASE; MESSENGER RNA; OSTEOPONTIN; PROTEIN BAX; PROTEIN P53; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM GLUCOSE COTRANSPORTER 2; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MEGADOSE; GENE EXPRESSION; GENE IDENTIFICATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HISTOPATHOLOGY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; TOXICOGENETICS; UNINDEXED SEQUENCE; UPREGULATION;

RATTUS;

EID: 77955517920     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2009.07.004     Document Type: Article

References (89)

1. Agre P., Nielsen S. The aquaporin family of water channels in kidney. Nephrologie 1996, 17:409-415.
2. Allan V.J., Thompson H.M., McNiven M.A. Motoring around the Golgi. Nat Cell Biol 2002, 4:E236-E242.
3. Amin R.P., Vickers A.E., Sistare F., et al. Identification of putative gene based markers of renal toxicity. Environ Health Perspect 2004, 112:465-479.
4. Aoyama C., Liao H., Ishidate K. Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res 2004, 43:266-281.
5. Bennett W.M., Mela-Riker L.M., Houghton D.C., et al. Microsomal protein synthesis inhibition: an early manifestation of gentamicin nephrotoxicity. Am J Physiol 1988, 255:F265-F269.
6. Beyer A., Hollunder J., Nasheuer H.P., Wilhelm T. Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale. Mol Cell Proteomics 2004, 3:1083-1092.
7. Bledsoe G., Shen B., Yao Y.Y., et al. Role of tissue Kallikrein in prevention and recovery of gentamicin-induced renal injury. Toxicol Sci 2008.
8. Boucrot E., Henry T., Borg J.P., et al. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science 2005, 308:1174-1178.
9. Buss W.C., Piatt M.K. Gentamicin administered in vivo reduces protein synthesis in microsomes subsequently isolated from rat kidneys but not from rat brains. J Antimicrob Chemother 1985, 15:715-721.
10. Castagnino P., Lorenzi M.V., Yeh J., et al. Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors. Oncogene 2000, 19:640-648.
11. Chen S., Smith D.F. Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery. J Biol Chem 1998, 273:35194-35200.
12. Chwieralski C.E., Welte T., Buhling F. Cathepsin-regulated apoptosis. Apoptosis 2006, 11:143-149.
13. Clarke E.J., Allan V. Intermediate filaments: vimentin moves in. Curr Biol 2002, 12:R596-R598.
14. Cowling V.H., Cole M.D. Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol 2006, 16:242-252.
15. D'Souza S., Garcia-Cabado A., Yu F., et al. The epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3 accumulates and is functional in recycling endosomes. J Biol Chem 1998, 273:2035-2043.
16. Desmots F., Rissel M., Loyer P., et al. Immunohistological analysis of glutathione transferase A4 distribution in several human tissues using a specific polyclonal antibody. J Histochem Cytochem 2001, 49:1573-1580.
17. Gocke C.D., Osmani S.A., Miller B.A. The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia. Histochem Cell Biol 2000, 114:293-301.
18. Goldstein L.S., Philp A.V. The road less traveled: emerging principles of kinesin motor utilization. Annu Rev Cell Dev Biol 1999, 15:141-183.
19. Goodman L.S., Hardman J.G., Limbird L.E., et al. Goodman & Gilman's the pharmacological basis of therapeutics 2001, McGraw-Hill Medical Pub. Division, New York.
20. Greenbaum D., Colangelo C., Williams K., et al. Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 2003, 4:117.
21. Guthmiller P., van Pilsum J.F., Boen J.R., McGuire D.M. Cloning and sequencing of rat kidney l-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine. J Biol Chem 1994, 269:17556-17560.
22. Hai T., Wolfgang C.D., Marsee D.K., et al. ATF3 and stress responses. Gene Expr 1999, 7:321-335.
23. Hammond T.G., Goda F.O., Navar G.L., et al. Membrane potential mediates H(+)-ATPase dependence of " degradative pathway" endosomal fusion. J Membr Biol 1998, 162:157-167.
24. Han W.K., Bailly V., Abichandani R., et al. Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 2002, 62:237-244.
25. Higa E.M., Schor N., Boim M.A., et al. Role of the prostaglandin and kallikrein-kinin systems in aminoglycoside-induced acute renal failure. Braz J Med Biol Res 1985, 18:355-365.
26. Howard M.T., Shirts B.H., Petros L.M., et al. Sequence specificity of aminoglycoside-induced stop condon readthrough: potential implications for treatment of Duchenne muscular dystrophy. Ann Neurol 2000, 48:164-169.
27. Hsu S.C., TerBush D., Abraham M., et al. The exocyst complex in polarized exocytosis. Int Rev Cytol 2004, 233:243-265.
28. Ishidoh K., Kominami E. Gene regulation and extracellular functions of procathepsin L. Biol Chem 1998, 379:131-135.
29. Jones J.D., Burnett P.C. Creatinine metabolism in humans with decreased renal function: creatinine deficit. Clin Chem 1974, 20:1204-1212.
30. Karin M., Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 2005, 57:283-295.
31. Kelly K.J., Meehan S.M., Colvin R.B., et al. Protection from toxicant-mediated renal injury in the rat with anti-CD54 antibody. Kidney Int 1999, 56:922-931.
32. Kilty C.G., Keenan J., Shaw M. Histologically defined biomarkers in toxicology. Expert Opin Drug Saf 2007, 6:207-215.
33. Kiyatake I., Nakamura T., Koide H. Urinary guanidinoacetic acid excretion as an indicator of gentamicin nephrotoxicity in rats. Ren Fail 2004, 26:339-344.
34. Kiyatake I., Nakamura T., Koide H. Urinary excretion of guanidinoacetic acid in rats with diabetic nephropathy. Ren Fail 2006, 28:177-180.
35. Kramer J.A., Pettit S.D., Amin R.P., et al. Overview on the application of transcription profiling using selected nephrotoxicants for toxicology assessment. Environ Health Perspect 2004, 112:460-464.
36. Kurz T., Terman A., Brunk U.T. Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron. Arch Biochem Biophys 2007, 462:220-230.
37. Laurent G., Carlier M.B., Rollman B., et al. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin. Biochem Pharmacol 1982, 31:3861-3870.
38. Lee J., Yoo K.S., Kang D.G., et al. Gentamicin decreases the abundance of aquaporin water channels in rat kidney. Jpn J Pharmacol 2001, 85:391-398.
39. Lesniak W., Pecoraro V.L., Schacht J. Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chem Res Toxicol 2005, 18:357-364.
40. Manuvakhova M., Keeling K., Bedwell D.M. Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system. RNA 2000, 6:1044-1055.
41. Maranda B., Brown D., Bourgoin S., et al. Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. J Biol Chem 2001, 276:18540-18550.
42. Marsenic O. Glucose control by the kidney: an emerging target in diabetes. Am J Kidney Dis 2009, 53:875-883.
43. Mitch W.E., Collier V.U., Walser M. Creatinine metabolism in chronic renal failure. Clin Sci 1980, 58:327-335.
44. Mingeot-Leclercq M.P., Tulkens P.M. Aminoglycosides: nephrotoxicity. Antimicrob Agents Chemother 1999, 43:1003-1012.
45. Miura K., Pasino D.A., Goldstein R.S., et al. Effects of gentamicin on renal function in isolated perfused kidneys from male and female rats. Toxicol Lett 1985, 26:15-18.
46. Moestrup S.K., Cui S., Vorum H., et al. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J Clin Invest 1995, 96:1404-1413.
47. Murakami H., Yayama K., Chao L., et al. Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats. Kidney Int 1998, 53:1305-1313.
48. Nagai J., Takano M. Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity. Drug Metab Pharmacokinet 2004, 19:159-170.
49. Nagy I., Bodmer M., Brors D., et al. Early gene expression in the organ of Corti exposed to gentamicin. Hear Res 2004, 195:1-8.
50. Nath K.A. Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues. Kidney Int 2006, 70:432-443.
51. Olbricht C.J., Fink M., Gutjahr E. Alterations in lysosomal enzymes of the proximal tubule in gentamicin nephrotoxicity. Kidney Int 1991, 39:639-646.
52. Palmer E., Wilhelm J.M. Mistranslation in a eucaryotic organism. Cell 1978, 13:329-334.
53. Perco P., Pleban C., Kainz A., et al. Protein biomarkers associated with acute renal failure and chronic kidney disease. Eur J Clin Invest 2006, 36:753-763.
54. Priuska E.M., Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 1995, 50:1749-1752.
55. Safirstein R.L. Acute renal failure: from renal physiology to the renal transcriptome. Kidney Int Suppl 2004, S62-S66.
56. Sakisaka T., Ikeda W., Ogita H., et al. The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors. Curr Opin Cell Biol 2007, 19:593-602.
57. Sandoval R.M., Molitoris B.A. Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am J Physiol Renal Physiol 2004, 286:F617-F624.
58. Sassen M.C., Kim S.W., Kwon T.H., et al. Dysregulation of renal sodium transporters in gentamicin-treated rats. Kidney Int 2006, 70:1026-1037.
59. Servais H., Jossin Y., Van B.F., et al. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrob Agents Chemother 2006, 50:1213-1221.
60. Servais H., Ortiz A., Devuyst O., et al. Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation. Apoptosis 2008, 13:11-32.
61. Sha S.H., Schacht J. Stimulation of free radical formation by aminoglycoside antibiotics. Hear Res 1999, 128:112-118.
62. Shaulian E., Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002, 4:E131-E136.
63. Shi L., Reid L.H., Jones W.D., et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol 2006, 24:1151-1161.
64. Sieber M., Hoffmann D., Adler M., et al. Comparative analysis of novel non-invasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity. Toxicol Sci 2009.
65. Smith DS, Niethammer M, Ayala R, et al. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nat Cell Biol. 2000, 2:767-775.
66. Song B.B., Schacht J. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res 1996, 94:87-93.
67. Song B.B., Anderson D.J., Schacht J. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther 1997, 282:369-377.
68. Steiner S., Aicher L., Raymackers J., et al. Cyclosporine A decreases the protein level of the calcium-binding protein calbindin-D 28kDa in rat kidney. Biochem Pharmacol 1996, 51:253-258.
69. Sun-Wada G.H., Wada Y., Futai M. Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase. Cell Struct Funct 2003, 28:455-463.
70. Suhl S.Y., Ahn D.W., Kim K.R., et al. Changes in renal brush-border sodium-dependent transport systems in gentamicin-treated rats. Korean J Physiol Pharmacol 1997, 1(4):403-411.
71. Takashi M., Zhu Y., Miyake K., et al. Urinary 28-kD calbindin-D as a new marker for damage to distal renal tubules caused by cisplatin-based chemotherapy. Urol Int 1996, 56:174-179.
72. Takahashi T., Morita K., Akagi R., et al. Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. Curr Med Chem 2004, 11:1545-1561.
73. Takeda M., Jung K.Y., Sekine T., et al. Guanidinoacetic acid (GAA) synthesis in rat tubular suspension as a system for evaluating gentamicin (GM) nephrotoxicity. Toxicol Lett 1995, 81:85-89.
74. Tang W.W., Feng L., Mathison J.C., et al. Cytokine expression, upregulation of intercellular adhesion molecule-1, and leukocyte infiltration in experimental tubulointerstitial nephritis. Lab Invest 1994, 70:631-638.
75. Taunton J. Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr Opin Cell Biol 2001, 13:85-91.
76. Thukral S.K., Nordone P.J., Hu R., et al. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Toxicol Pathol 2005, 33:343-355.
77. Vaidya V.S., Bonventre J.V. Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin Drug Metab Toxicol 2006, 2:697-713.
78. van de Water B., de Graauw M., Le Devedec S., et al. Cellular stress responses and molecular mechanisms of nephrotoxicity. Toxicol Lett 2006, 162:83-93.
79. van Pilsum J.F., McGuire D.M., Miller C.A. The antagonistic action of creatine and growth hormone on the expression of the gene for rat kidney l-arginine:glycine amidinotransferase. Guanidino compounds in biology and medicine 1992, 147-151. Libbey, London. P.P. De Deyn, B. Marescau, V. Stalon, I.A. Qureshi (Eds.).
80. Verstrepen W.A., Nouwen E.J., Yue X.S., et al. Altered growth factor expression during toxic proximal tubular necrosis and regeneration. Kidney Int 1993, 43:1267-1279.
81. Walker P.D., Shah S.V. Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 1988, 81:334-341.
82. Wang E.J., Snyder R.D., Fielden M.R., et al. Validation of putative genomic biomarkers of nephrotoxicity in rats. Toxicology 2008, 246:91-100.
83. Wang X.Z., Lawson B., Brewer J.W., et al. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 1996, 16:4273-4280.
84. Welch W.J. Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev 1992, 72:1063-1081.
85. Wennerberg K., Rossman K.L., Der C.J. The Ras superfamily at a glance. J Cell Sci 2005, 118:843-846.
86. Wyss M., Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000, 80:1107-1213.
87. Yuen P.S., Jo S.K., Holly M.K., et al. Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses. Physiol Genomics 2006, 25:375-386.
88. Zaidi N., Maurer A., Nieke S., et al. Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun 2008, 376:5-9.
89. Zhou Y., Vaidya V.S., Brown R.P., et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 2008, 101:159-170.