Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 287-290

  Bajgar, Jiri ^a   Karasova, Jana Zdarova ^a   Kassa, Jiri ^a   Cabal, Jiri ^a   Fusek, Josef ^a   Blaha, Vaclav ^b   Tesarova, Sandra ^c  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c 7th Field Hospital   (Czech Republic)

Author keywords

Acetylcholinesterase; Blood; Brain parts; Diaphragm; Rat; Reactivators; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ATROPINE; TABUN; TRIMEDOXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN REGION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REACTIVATION; FEMALE; IN VIVO STUDY; INTOXICATION; NONHUMAN; RAT; TISSUE DISTRIBUTION;

RATTUS;

EID: 77955511128     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.02.009     Document Type: Article

References (26)

1. Bajgar J. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv. Clin. Chem. 2004, 38:151-216.
2. Marrs T.C. Organophosphate anticholinesterase poisoning. Toxic Subst. Mech. 1996, 15:357-388.
3. Wiener S.W., Hoffman R.S. Nerve agents: a comprehensive review. J. Int. Care Med. 2004, 19:22-37.
4. Rotenberg J.S., Newmark J. Nerve attacks on children: diagnosis and management. Pediatrics 2003, 112:648-658.
5. Eyer P. The role of oximes in the management of organophosphorus pesticides poisoning. Toxicol. Rev. 2003, 22:165-190.
6. Bajgar J., Fusek J., Kuca K., Bartosova L., Jun D. Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction. Mini Rev. Med. Chem. 2007, 7:461-466.
7. Bajgar J., Kuca K., Jun D., Bartosova L., Fusek J. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Curr. Drug Metab. 2007, 8:803-809.
8. Kuca K., Musilek K., Jun D., Bajgar J., Kassa J. Novel oximes. Handbook of Toxicology of Chemical Warfare Agents 2009, 997-1021. Elsevier, (Chapter 66). R.C. Gupta (Ed.).
9. Worek F., Aurbek N., Thiermann H. Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI-6 in vitro. J. Appl. Toxicol. 2007, 27:582-588.
10. Maksimovic M., Pantelic D., Kovacevic V., Binenfeld Z. Protective effect of HI-6 and Toxogonin combinations in soman- and tabun-poisoned rats. Acta Pharm. Yugoslav 1987, 37:227-229.
11. Clement J.G., Shiloff J.D., Gennings C. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice. Arch. Toxicol. 1987, 61:70-75.
12. Kassa J., Kuca K., Cabal J. Comparison of the efficacy of currently available oximes against tabun in rats. Biologia 2005, 60(Suppl. 17):77-79.
13. Kassa J., Karasova J., Bajgar J., Kuca K., Musilek K., Popelikova I. A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice. J. Enzym. Inhib. Med. Chem. 2009, 24:1041-1044.
14. Kassa J., Humlicek V. A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice. Drug Chem. Toxicol. 2008, 31:127-135.
15. Ellman G.L., Courtney D.K., Andres V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961, 7:88-95.
16. Bajgar J. Biological monitoring of exposure to nerve agents. Brit. J. Ind. Med. 1992, 49:648-653.
17. Bajgar J. Time course of acetylcholinesterase inhibition in the medulla oblongata of the rat by O-ethyl S-(2-dimethylaminoethyl) methylphosphonothioate in vivo. Brit. J. Pharmacol. 1972, 45:368-371.
18. Giacobini G. Cholinesterases in human brain: the effect of cholinesterase inhibitors on Alzheimer's disease related disorders. The Brain Cholinergic System in Health and Disease 2006, 235-264. Informa Healthcare, Abingdon, UK. E. Giacobini, G. Pepeu (Eds.).
19. Kassa J., Karasova-Zdarova J., Pavlikova R., Misik J., Caisberger F., Bajgar J. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice. J. Appl. Toxicol. 2010, 30:120-124.
20. Berend S., Lucic Vrdoljak A., Radic B., Kuca K. New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning. Chem. Biol. Interact. 2008, 175:413-416.
21. Gupta R.C., Patterson G.T., Dettbarn W.-D. Biochemical and histochemical alterations following acute soman intoxication in the rat. Toxicol. Appl. Pharmacol. 1987, 87:393-402.
22. Shih T.-M., Kan R.K., McDonough J.H. In vivo cholinesterase inhibitory specificity of organophosphorus nerve agents. Chem. Biol. Interact. 2005, 157-158:293-303.
23. Bajgar J., Hajek P., Slizova D., Krs O., Fusek J., Kuca K., Jun D., Bartosova L., Blaha V. Changes of acetylcholinesterase activity in different brain areas following intoxication with nerve agents: biochemical and histochemical study. Chem. Biol. Interact. 2007, 165:14-21.
24. Bajgar J., Fusek J., Kassa J., Jun D., Kuca K., Hajek P. An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents. Chem. Biol. Interact. 2008, 175:281-285.
25. Bajgar J., Sevelova L., Krejcova G., Fusek J., Vachek J., Kassa J., de Jong L., Benschop H. Biochemical and behavioral effects of soman vapors in low concentrations. Inhal. Toxicol. 2004, 16:497-507.
26. Karasova-Zdarova J., Novotny L., Antos K., Zivna H., Kuca K. Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration. Anal. Sci. 2010, 26:63-67.