The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice

Journal of Applied Toxicology

Volumn 30, Issue 2, 2010, Pages 120-124

  Kassa, Jiri ^a   Karasova, Jana Zdarova ^a   Pavlikova, Ruzena ^a   Misik, Jan ^a   Caisberger, Filip ^b   Bajgar, Jiri ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Acetylcholinesterase; HI 6; K203; Mice; Obidoxime; Rats; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; K 203; OBIDOXIME; OXIME; TABUN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIAPHRAGM; DRUG EFFICACY; DRUG STRUCTURE; GAS POISONING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TABUN POISONING; TREATMENT OUTCOME;

ACETYLCHOLINESTERASE; ANIMALS; ANTIDOTES; CHOLINESTERASE REACTIVATORS; DRUG THERAPY, COMBINATION; MALE; OBIDOXIME CHLORIDE; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR;

MUS; RATTUS;

EID: 77249127970     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1477     Document Type: Article

References (31)

1. Bajgar J. 2004. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv. Clin. Chem. 38: 151-216.
2. Bajgar J. 2005. Complex view on poisoning with nerve agents and organophosphates. Acta Med. (Hradec Kralove) 48: 3-21.
3. Cabal J, Bajgar J. 1999. Tabun - reappearance 50 years later (in Czech). Chem. Listy 93: 27-31.
4. Clement JG, ShiloffJD, Gennings Ch. 1987. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice. Arch. Toxicol. 61: 70-75.
5. Clement JG, Hansen AS, Boulet CA. 1992. Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Arch. Toxicol. 66: 216-219.
6. Dawson RM. 1994. Review of oximes available for treatment of nerve agent poisoning. J. Appl. Toxicol. 14: 317-331.
7. Ekström F, Akfur C, Tunemalm AK, Lundberg S. 2006. Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase. Biochemistry 45: 74-81.
8. Ellman GL, Courtney DK, Andres VJr, Feartherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7: 88-93.
9. Kassa J. 2002. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J. Toxicol. Clin. Toxicol. 40: 803-816.
10. Kassa J, Cabal J. 1999a. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology 132: 111-118.
11. Kassa J, Cabal J. 1999b. A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexylmethylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol. Toxicol. 84: 41-45.
12. Kassa J, Kuca K, Bartosova L, Kunesova G. 2007. The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and therapeutic efficacy with currently available oximes. Curr. Org. Chem. 11: 267-283.
13. Kassa J, Karasova J, Musilek K, Kuca K. 2008. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243: 311-316.
14. Kovacevic V, Maksimovic M, Pantelic D, Vojvodic V, Binenfeld Z. 1989. Protective and reactivating effects of HI-6 PAM-2 mixture in rats poisoned with nerve chemical warfare agents. Acta Pharm. Jugoslav. 39: 161-165.
15. Kovacevic V, Maksimovic M, Deljac V, Binenfeld Z. 1991. Protective effects of mixture of oximes in poisoning by nerve chemical warfare agents. Acta Pharm. Jugoslav. 41: 75-78.
16. Kovarik Z, Lucic Vrdoljak A, Berend S, Catalinic M, Kuca K, Musilek K, Radic B. 2009. Evaluation of oxime K203 as antidote in tabun poisoning. Arh. Hig. Rada Toksikol. 60: 19-26.
17. Lawrence DT, Kirk MA. 2007. Chemical terrorism attacks: update on antidotes. Emerg. Med. Clin. N. Am. 25: 567-595.
18. Lorke DE, Petroianu GA. 2009. Minireview: does in-vitro testing of oximes help predict their in-vivo action after paraoxon exposure? J. Appl. Toxicol. DOI 10.1002/jat.1457.
19. Lorke DE, Hasan MY, Arafat K, Kuca K, Musilek K, Schmitt A, Petroianu GA. 2008. In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropylfluorophosphate. J. Appl. Toxicol. 28: 422-429.
20. Lotti M. 2000. Organophosphorus compounds. In Experimental and Clinical Neurotoxicology, Spencer PS, Schaumburg HH (eds). Oxford University Press: New York; 898-925.
21. Lundy PM, Raveh L, Amitai G. 2006. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol. Rev. 25: 231-243.
22. Maksimovic M, Kovacevic V. 1989. Protective and reactivating effects of HI-6-toxogonin mixture in rats and guinea-pigs poisoned by nerve agents. Acta Pharm. Jugoslav. 39: 27-33.
23. Marrs TC. 1993. Organophosphate poisoning. Pharmacol. Ther. 58: 51-66.
24. Marrs TC, Rice P, Vale JA. 2006. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol. Rev. 25: 297-323.
25. Maxwell DM, Koplovitz I, Worek F, Sweeney RE. 2008. A structure-activity analysis of the variation in oxime efficacy against nerve agents. Toxicol. Appl. Pharmacol. 231: 157-164.
26. Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M. 2007a. Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. J. Enzym. Inhib. Med. Chem. 23: 70-76.
27. Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K. 2007b. Design of a potent reactivator of tabun-inhibited acetylcholinesterase - synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4- hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). J. Med. Chem. 50: 5514-5518.
28. Musilek K, Kuca K, Jun D, Dolezal M. 2007c. Progress in synthesis of new acetylcholinesterase reactivators in period 1990-2004. Curr. Org. Chem. 11: 229-238.
29. Ohtomi S, Takase M, Kumagai F. 1996. Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int. Rev. Arm. Ser. 69: 97-102.
30. Tallarida R, Murray R. 1987. Manual of Pharmacological Calculation with Computer Programs. Springer: New York.
31. Worek F, Aurbek N, Thiermann H. 2007. Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. J. Appl. Toxicol. 27: 582-588.