New bispyridinium oximes: In vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 413-416

  Berend, Suzana ^a   Vrdoljak, Ana Lucić ^a   Radić, Božica ^a   Kuča, Kamil ^b  

^a INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Antidotal efficacy; Oxime; Soman; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 4 (4 CARBAMOYLPYRIDINIUM)BUTANE; 1,3 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE; 1,4 BIS(2 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; K 027; K 033; K 048; K 074; NERVE GAS; OXIME DERIVATIVE; PYRIDINIUM DERIVATIVE; SOMAN; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; ERYTHROCYTE; EVALUATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMICAL WARFARE AGENTS; ENZYME REACTIVATORS; HUMANS; LETHAL DOSE 50; MALE; MICE; MICE, INBRED BALB C; OXIMES; PHOSPHORIC ACID ESTERS; POISONING; PYRIDINIUM COMPOUNDS; SOMAN;

MUS;

EID: 50649116169     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.04.031     Document Type: Article

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