Cholinesterase reactivators: The fate and effects in the organism poisoned with organophosphates/nerve agents

Current Drug Metabolism

Volumn 8, Issue 8, 2007, Pages 803-809

  Bajgar, J ^a   Kuca, K ^a,b   Jun, D ^a,b   Bartosova, L ^a   Fusek, J ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Blood brain barrier; Cholinesterase reactivators; Nerve agents; Oximes; Pesticides; Pharmacodynamics; Pharmacokinetics; Quaternary

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; ALDOXIME; ANTICONVULSIVE AGENT; ATROPINE; BICARBONATE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; DIAZEPAM; DICHLORVOS; K 048; K 27; K 48; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NERVE GAS; OBIDOXIME; ORGANOPHOSPHATE; ORGANOPHOSPHATE INSECTICIDE; OXIME DERIVATIVE; PRALIDOXIME; SARIN; SOMAN; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTIFICIAL VENTILATION; CHOLINERGIC SYSTEM; CHOLINESTERASE INHIBITION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONVULSION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; ENZYME REACTIVATION; HUMAN; INTOXICATION; LD 50; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; REVIEW; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; ANTIDOTES; BLOOD-BRAIN BARRIER; CHOLINESTERASE REACTIVATORS; CHOLINESTERASES; DIAZEPAM; HUMANS; MOLECULAR STRUCTURE; NEUROTRANSMITTER AGENTS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PESTICIDES; SEIZURES;

EID: 36949036663     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007782798144     Document Type: Review

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