Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets

Vaccine

Volumn 28, Issue 37, 2010, Pages 6006-6013

  Cao, Ding ^a   Li, Huazhou ^b   Jiang, Zhenggu ^b   Xu, Chenchao ^a   Cheng, Qing ^a   Yang, Zhaihan ^b   Cao, Guangjun ^a   Zhang, Linghua ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b Swine Seed Breeding Center of Guangzhou   (China)

Author keywords

CpG ODN; Immune response; Innate defense regulator peptides; Newborn piglets

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; CXCL11 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOSTIMULATING AGENT; INDOLICIDIN; INTERLEUKIN 12; INTERLEUKIN 4; LYSYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLLEUCYLLEUCYLLYSYLLEUCYLLYSINE; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; RI BAC2A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VALYLGLUTAMINYLLEUCYLARGINYLISOLEUCYLARGINYLVALYLALANYLVALYLISOLEUCYLARGINYLALANINE; CPG-OLIGONUCLEOTIDE; CYTOKINE; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG POTENTIATION; IMMUNOSTIMULATION; IN VIVO STUDY; INNATE IMMUNITY; LEUKOCYTE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PIGLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; ANIMAL; BLOOD; IMMUNIZATION; IMMUNOLOGY; MONONUCLEAR CELL; SWINE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANIMALS, NEWBORN; CYTOKINES; IMMUNITY, INNATE; IMMUNIZATION; LEUKOCYTES, MONONUCLEAR; OLIGODEOXYRIBONUCLEOTIDES; SWINE;

EID: 77955510250     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.06.103     Document Type: Article

References (45)

1. Monroe S., Polk R. Antimicrobial use and bacterial resistance. Curr Opin Microbiol 2000, 3:496-501.
2. Schwarz S., Kehrenberg C., Walsh T.R. Use of antimicrobial agents in veterinary medicine and food animal production. Int J Antimicrob Agents 2001, 17:431-437.
3. Neu H.C. The crisis in antibiotic resistance. Science 1992, 257:1064-1073.
4. Hemmi H., Takeuchi O., Kawai T., Sato S., Sanjo H., Matsumoto M., et al. A toll-like receptor recognizes bacterial DNA. Nature 2000, 408:740-745.
5. Medzhitov R., Preston-Hurlburt P., Janeway J.R. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
6. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124(4):783-801.
7. Kumar H., Kawai T., Akira S. Toll-like receptors and innate immunity. Biochem Biophys Res Commun 2009, 388(4):621-625.
8. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002, 20:709-760.
9. Harandi A.M., Eriksson K., Holmgren J. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J Virol 2003, 77(2):953-962.
10. Ashkar A.A., Bauer S., Mitchell W.J., Vieira J., Rosenthal K.L. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J Virol 2003, 77(16):8948-8956.
11. Olbrich A.R., Schimmer S., Heeg K., Schepers K., Schumacher T.N., Dittmer U. Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs. J Virol 2002, 76(22):11397-11404.
12. Verthelyi D., Gursel M., Kenney R.T., Lifson J.D., Liu S., Mican J., et al. CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection. J Immunol 2003, 170(9):4717-4723.
13. Juffermans N.P., Leemans J.C., Florquin S., Verbon A., Kolk A.H., Speelman P., et al. CpG oligodeoxynucleotides enhance host defense during murine tuberculosis. Infect Immun 2002, 70(1):147-152.
14. Oppenheim J.J., Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol 2005, 17:359-365.
15. Bowdish D.M.E., Davidson D.J., Lau Y.E., Lee K., Scott M.G., Hancock R.E.W. Impact of LL-37 on anti-infective immunity. J Leukocyte Biol 2005, 77:451-459.
16. Niyonsaba F., Someya A., Hirata M., Ogawa H., Nagaoka I. Evaluation of the effects of peptide antibiotics human betadefensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur J Immunol 2001, 31:1066-1075.
17. Lau Y.E., Bowdish D.M., Cosseau C., Hancock R.E., Davidson D.J. Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37. Am J Respir Cell Mol Biol 2006, 34:399-409.
18. Kindrachuk J., Jenssen H., Elliott M., Townsend R., Nijnik A., Lee S.F., et al. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine 2009, 27:4662-4671.
19. Schellack C., Schellack C., Prinz K., Egyed A., Fritz J.H., Wittmann B., et al. Buschle M, Lingnau K. IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses. Vaccine 2006, 24:5461-5472.
20. Kovacs-Nolan J., Latimera L., Landia A., Jenssenb H., Hancockb R.E.W., Babiukc L.A., et al. The novel adjuvant combination of CpG ODN, indolicidin and polyphosphazene induces potent antibody- and cell-mediated immune responses in mice. Vaccine 2009, 27:2055-2064.
21. Scrutena E., Kovacs-Nolan J., Griebel P.J., Latimer L., Kindrachuk J., Potter Andy, et al. Retro-inversion enhances the adjuvant and CpG co-adjuvant activity of host defence peptide Bac2A. Vaccine 2010, 28:2945-2956.
22. Cheng Q., Xu C.C., Zhang L.H., Li J.Q., Cao T., Zhang M.R. Administered CpG Oligodeoxynucleotide Induces mRNA expression of CXC and CC Chemokines at the Intestinal Mucosa and PBMCs in Piglets. Int Immunopharmacol 2010, 10:611-618.
23. Kamstrup S., Verthelyi D., Klinman D.M. Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides. Vet Microbiol 2001, 78:353-362.
24. Masuda K., Sakaguchi M., Saito S., Deboer D.J., Fujiwara S., Kurata K., et al. In vivo and in vitro tests showing sensitization to Japanese cedar (Cryptomeria japonica) pollen allergen in atopic dogs. J Vet Med Sci 2000, 62:995-1000.
25. Asmi C.M., Tassakka A.R., Savan R., Watanuki H., Sakai M. The in vitro effects of CpG oligodeoxynucleotides on the expression of cytokine genes in the common carp (Cyprinus carpio L.) head kidney cells. Vet Immunol Immunopathol 2006, 110(1-2):79-85.
26. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 2001, 25:402-408.
27. Zhang L.H., Tian X.S., Zhou F.Z. In vivo immunostimulatory effects of CpG ODN in newborn piglets. Mol Immunol 2007, 44(6):1238-1244.
28. Solano-Aguilar G.I., Vengroski K.G., Beshah E., Douglass L.W., Lunney J.K. Characterization of lymphocyte subsets from mucosal tissues in neonatal swine. Dev Comp Immunol 2001, 25:245-263.
29. Zhang L.H., Guo Y., Tian X.S., Zhou F.Z. Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Dev Comp Immunol 2006, 30(6):589-596.
30. Haverson K., Bailey M., Higgins V.R., Bland P.W., Stokes C.R. Characterization of monoclonal antibodies specific for monocytes, macrophages and granulocytes from porcine peripheral blood and mucosal tissues. J Immunol Methods 1994, 170(2 (April 15)):233-245.
31. Haverson K., Bailey M., Higgins V.R., Bland P.W., Stokes C.R. Characterization of monoclonal antibodies specific for monocytes, macrophages and granulocytes from porcine peripheral blood and mucosal tissues. J Immunol Methods 1994, 170:233-245.
32. Alvarez B., Sanchez C., Bullido R., Marina A., Lunney J., Alonso F., et al. A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Tissue Antigens 2000, 55:342-351.
33. Magyar A., Mihalik R., Oláh I. The surface phenotype of swine blood and tissue eosinophil granulocytes. Vet Immunol Immunopathol 1995, 47(3-4):273-281.
34. Summerfield A., McCullough K.C. Porcine bone marrow myeloid cells: phenotype and adhesion molecule expression. J Leukocyte Biol 1997, 62(2):176-185.
35. Grierson S.S., King D.P., Tucker A.W., Donadeu M., Mellencamp M.A., Haverson K., et al. Ontogeny of systemic cellular immunity in the neonatal pig: Correlation with the development of post-weaning multisystemic wasting syndrome. Vet Immunol Immunopathol 2007, 119:254-268.
36. Easton D.M., Nijnik A., Mayer M.L., Hancock R.E.W. Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol 2009, 27(10):582-590.
37. Zinkernagel R.M. Localization dose and time of antigens determine immune reactivity. Semin Immunol 2000, 12:163.
38. Hacker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T., et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 1998, 17:6230-6240.
39. Yi A.K., Krieg A.M. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J Immunol 1998, 161:4493-4497.
40. Krieg A.M., McCluskie M.J. Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Curr Top Microbiol Immunol 2006, 311:155-178.
41. Mohamed Z. Multifunctional antimicrobial peptides: therapeutic targets in several human diseases. J Mol Med 2007, 85:317-329.
42. Siegrist C.A. The challenges of vaccine responses in early life: selected examples. J Comp Pathol 2007, 137(Suppl. 1):S4-S9.
43. Adkins B., Leclerc C., Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004, 4:553-564.
44. Luster A.D. The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 2002, 14:129-135.
45. Moser B., Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001, 2:123-128.