The role of gp130-mediated signals in osteoclast development: Regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures

Journal of Experimental Medicine

Volumn 183, Issue 6, 1996, Pages 2581-2591

  Romas, Evangelos ^a   Udagawa, Nobuyuki ^a   Zhou, Hong ^a   Tamura, Tatsuya ^b   Saito, Mikiyoshi ^b   Taga, Tetsuya ^c   Hilton, Douglas J ^a   Suda, Tatsuo ^d   Ng, Kong Wah ^a   Martin, T John ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; GLYCOPROTEIN; INTERLEUKIN 11; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN RECEPTOR; MESSENGER RNA; PARATHYROID HORMONE; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BONE REMODELING; CELL PROLIFERATION; CELLULAR DISTRIBUTION; DOSE RESPONSE; GROWTH REGULATION; IMMUNOREGULATION; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RECEPTOR DENSITY;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BASE SEQUENCE; BONE MARROW; BONE MARROW CELLS; CALCITRIOL; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINE RECEPTOR GP130; CYTOKINES; DINOPROSTONE; DNA PRIMERS; HUMANS; IN SITU HYBRIDIZATION; INTERLEUKIN-1; INTERLEUKIN-11; INTERLEUKIN-11 RECEPTOR ALPHA SUBUNIT; KINETICS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; PARATHYROID HORMONE; POLYMERASE CHAIN REACTION; RATS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-11; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 15844429135     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.6.2581     Document Type: Article

References (46)

1. Paul, S.R., F. Bennett, J.A. Calvetti, K. Kelleher, C.R. Wood, R.M. O'Hara Jr., A.C. Leary, B. Sibley, S.C. Clark, D.A. Williams, and Y.C. Yang. 1990. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic cytokine. Proc. Natl. Acad. Sci. USA. 87:7512-7516.
2. Elias, J.A., T. Zheng, N.L. Whiting, T.K. Trow, W.W. Merrill, R. Zitnik, P. Ray, and E.M. Alderman. 1994. Interleukin-1 and transforming growth factor-β regulation of fibroblast derived interleukin-11. J. Immunol. 152:2421-2429.
3. Rubin, L.P., S.W Tsai, R.C. Ireland, R. McGinnis, C. Lovene, and S.R. Paul. 1994. Parathyroid hormone related protein can regulate human trophoblast differentiation via induction of interleukin 11 in placental stromal cells. J. Bone. Min. Res. 9:S342. (Abstr.)
4. Maier, R., V. Ganu, and M. Lotz. 1993. Interleukin 11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J. Biol. Chem. 268:21527-21532.
5. Yin, T., K. Miyazawa, and Y. Yang. 1992. Characterization of interleukin-11 receptor and protein tyrosine kinase phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells. J. Biol. Chem. 267:8347-8351.
6. Hilton, D.J., A.A. Hilton, A. Raicevic, S. Rakar, M. Harrison-Smith, N.M. Gough, G. Begley, D. Metcalf, N. Nicola, and T. Willson. 1994. Cloning of a murine IL-11 receptor α-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO (Eur. Mol. Biol. Organ.) J. 13: 4765-4775.
7. Taga, T., M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, and T. Kishimoto. 1989. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 58:513-581.
8. Yin, T., T. Taga, L. Tsang, K. Yasukawa, T. Kishimoto, and Y. Yang. 1993. Involvement of IL-6 signal transducer gp130 in IL-11 mediated signal transduction. J. Immunol. 151:2555-2561.
9. Lutticken, C., U.M Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A.G. Harpur, A.F. Wilks, K. Yasukawa, T. Taga et al. 1994. Association of transcription factor APRF and protein kinase JAK 1 with the interleukin 6 signal transducer gp130. Science (Wash. DC). 263:89-92.
10. Yin, T., K. Yasukawa, T. Taga, T. Kishimoto, and Y.C. Yang. 1994. Identification of 130kDa tyrosine phosphorylated protein induced by interleukin-11 as JAK 2 tyrosine kinase, which associates with gp130 signal transducer. Exp. Hematol. 22:467-472.
11. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell. 76:253-262.
12. Kishimoto, T., S. Akira, N. Narazaki, and T. Taga. 1995. Interleukin-6 Family of Cytokines and gp130. Blood. 86:1243-1254.
13. Neuhaus, H., B. Bettenhausen, P. Bilinski, D. Simon-Chazottes, J. Guenet, and A. Gossler. 1994. Etl2, a novel putative type-I cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential. Dev. Biol. 166:531-542.
14. Elias, J.A., W. Tang, and M. Horowitz. 1995. Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. Endocrinology. 136:489-498.
15. Girasole, G., G. Passen, R.L. Jilka, and S.C. Manolagas. 1994. Interleukin-11: a new cytokine critical for osteoclast development. J. Clin. Invest. 93:1516-1524.
16. Tamura, T., N. Udagawa, N. Takahashi, C. Miyaura, S. Tanaka, Y. Yamada, Y. Koishihara, Y. Ohsugi, K. Kumaki, T. Taga, T. Kishimoto, and T. Suda. 1993. Soluble IL-6 receptor triggers osteoclast formation by interleukin 6. Proc. Natl. Acad. Sci. USA. 90:11924-11928.
17. Udagawa, N., N. Takahashi, T. Katagiri, T. Tamura, S. Wada, D.M. Findlay, T.J. Martin, H. Hirota, T. Taga, T. Kishimoto and T. Suda. 1995. IL-6 induction of osteoclast differentiation depends upon IL-6 receptors expressed on osteoblastic cells, but not on osteoclast progenitors. J. Exp. Med. 182:1461-1468.
18. Takahashi, N., H. Yamana, S. Yoshiki, G.D. Roodman, G.R. Mundy, S.J. Jones, A. Boyde, and T. Suda. 1988. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology. 122:1373-1382.
19. Akatsu, T., T. Tamura, N. Takahashi, N. Udagawa, S. Tanaka, T. Sasaki, A. Yamaguchi, N. Nagata, and T. Suda. 1992. Preparation and characterization of a mouse osteoclast-like multinucleated cell population. J. Bone. Miner. Res. 7: 1297-1306.
20. Ikegame, M., M. Rakopoulos, H. Zhou, S. Houssami, T.J. Martin, J.M. Moseley, and D. Findlay. 1995. Calcitonin receptor isoforms in mouse and rat osteoclasts. J. Bone. Miner. Res. 10:59-65.
21. Udagawa, N., N. Takahashi, T. Akatsu, T. Sasaki, A. Yamaguchi, H. Kodama, T.J. Martin, and T. Suda. 1989. The bone marrow derived stromal cell lines MC3T3-G2/ PA6 and ST-2 support osteoclast-like cell differentiation in co-cultures with mouse spleen cells. Endocrinology. 125:1805-1813.
22. Udagawa, N., N. Takahashi, T. Akatsu, S. Tanaka, A. Sasaki, T. Nishihara, T. Koga, T.J. Martin, and T. Suda. 1990. Origin of osteoclasts: mature monocyte-macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow derived stromal cells. Proc. Natl. Acad. Sci. USA. 87:7260-7264.
23. Palacios, R., and M. Steinmetz. 1985. IL-3 dependent clones that express B-220 surface antigen, contain Ig Genes in germ line configuration, and generate B-lymphocytes in-vivo. Cell. 41:727-734.
24. Metcalf, D. 1984. Haemopoietic Colony Stimulating Factors. Elselvier, Amsterdam.
25. Saito, T., K. Yasukawa, H. Suzuki, K. Futatsugi, T. Fukunaga, C. Yokomizo, Y. Koishihara, H. Fukui, Y. Ohsugi, H. Yawata et al. 1991. Preparation of soluble murine IL-6 receptor and anti-munne IL-6 receptor antibodies. J. Immunol. 147:168-173.
26. Chomzynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by guanidinium thiocyanate-phenol chloroform extraction. Anal. Biochem. 162:156-159.
27. Saito, M., K. Yoshida, M. Hibi, T. Taga, and T. Kishimoto. 1992. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in-vivo. J. Immunol. 148:4066-4071.
28. Zhou, H., R.G. Hammonds Jr., D. Findlay, P.J. Fuller, T.J. Martin, and K.W. Ng. 1991. Retinoic acid modulation of mRNA levels in malignant, nontransformed and immortalized osteoblasts. J. Bone. Miner. Res. 6:767-777.
29. Tso, J.Y., X.H. Sun, T.H. Kao, K.S. Reece, and R. Wu. 1985. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucl. Acids Res. 13:2485-2502.
30. Zhou, H., P. Choong, R. McCarty, S.T. Chou, T.J. Martin, and K.W. Ng. 1994. In situ hybridization to show sequential expression of osteoblast gene markers during bone formation in-vivo. J. Bone. Miner. Res. 9:1489-1499.
31. Takahashi, N., T. Akatsu, N. Udagawa, T. Sasaki, A. Yamaguchi, J.M. Moseley, T.J. Martin, and T. Suda. 1988. Osteoblastic cells are involved in osteoclast formation. Endocrinology. 123:2600-2602.
32. Suda, T., N. Takahashi, and T.J. Martin. 1992. Modulation of Osteoclast Differentiation. In Endocrine. Rev. 13:66-80.
33. Suda, T., N. Takahashi, and T.J. Martin. 1995. Modulation of osteoclast differentiation: update. In Endocrine Review, Monographs vol. 4. D.D. Bikle and A. Negrovilar, editors. Endocrine Society, Bethesda, MD. 266-270.
34. 2. Biochem. Biophys. Res. Commun. 102:1358-1365.
35. Feyan, J.H.M., G. Van der Wilt, P. Moonen, A. DiBon, and P.J. Nijiweide. 1984. Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs. Prostaglandins. 28:213-220.
36. Ikeda, E., M. Kusaka, V. Hakeda, K. Yokota, M. Kumegawa, and S. Yamamoto. 1988. Effects of interleukin-1β on osteoblastic clone MC3T3-E1 cells. Calcif. Tissue. Int. 43:162-166.
37. Tashjian, A.H., E.F. Voelkel, M. Lazzaro, F.R. Singer, A.B. Roberts, R. Derynck, M.E. Winkler, and L. Levine. 1985. α and β human transforming growth factor stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Prof. Natl. Acad. Sci. USA. 82:4535-4538.
38. Shinar, D.M., and G.A. Rodan. 1990. Biphasic effects of transforming growth factor-β on the production of osteoclast-like cells in mouse bone marrow cultures: the role of prostaglandins in the generation of these cells. Endocrinology. 126:3153-3158.
39. Akatsu, T., N. Takahashi, N. Udagawa, K. Imamura, A. Yamaguchi, K. Sata, N. Nagata, and T. Suda. 1991. Role of prostaglandins in interleukin-1 induced bone resorption in mice in-vitro. J. Bone. Miner. Res. 6:183-190.
40. Yang, L., and Y. Yang. 1994. Regulation of Interleukin (IL)-11 Gene Expression in IL-1 induced primate bone marrow cells. J. Biol. Chem. 269:32732-32739.
41. Bellido, T., N. Stahl, R.L. Jilka, G. Epstein, G. Yancopoulos, and S.C. Manolagas. 1995. Bone active hormones regulate the gp130 signal transduction pathway. Bone. 16:142S. (Abstr.)
42. Manolagas S.C. 1995. Role of cytokines in Bone Resorption. Bone. 16:91S. (Abstr.)
43. Yoshida, K., T. Taga, M. Saito, S. Suematsu, A. Kumanogoh, T. Tanaka, H. Fujiwara, M. Hirata, T. Yamagami, T. Nakahata et al. 1996. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA. 93:407-411.
44. Ohsaki, Y., S. Takahashi, T. Scarcez, A. Demulder, T. Nishihara, R. Williams, and G.D. Roodman. 1992. Evidence for an autocrine-paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology. 131:2229-2234.
45. Jimi, E., T. Shuto, and T. Koga. 1995. Macrophage colony stimulating factor and Interleukin-1α maintain the survival of osteoclast-like cells. Endocrinology. 136:808-811.
46. Arend, W.P., and J.M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor in rheumatoid arthritis. Arthritis Rheum. 38:151-160.