Detoxification of aristolochic acid I by O-demethylation: Less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents

International Journal of Cancer

Volumn 127, Issue 5, 2010, Pages 1021-1027

  Shibutani, Shinya ^a   Bonala, Radha R ^a   Rosenquist, Thomas ^a   Rieger, Robert ^a   Suzuki, Naomi ^a   Johnson, Francis ^a   Miller, Frederick ^a   Grollman, Arthur P ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Aristolochic acid; DNA adduct; Genotoxicity; Nephrotoxicity

Indexed keywords

ARISTOLOCHIC ACID; ARISTOLOCHIC ACID 1A; DNA; O DEMETHYLASE; PHOSPHORUS 32; UNCLASSIFIED DRUG; ZINC; ARISTOLOCHIC ACID I; CALF THYMUS DNA; CARCINOGEN;

ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALF (BOVINE); CHRONIC DISEASE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DEMETHYLATION; DNA ADDUCT; DRUG DETERMINATION; DRUG DETOXIFICATION; DRUG ISOLATION; DRUG URINE LEVEL; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; KIDNEY CORTEX; KIDNEY DISEASE; MALE; MASS SPECTROMETRY; METABOLITE; MOUSE; NEOPLASM; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; THYMUS; ANIMAL; C3H MOUSE; CHEMICALLY INDUCED DISORDER; GENETICS; ISOLATION AND PURIFICATION; METHYLATION; PATHOLOGY; URINE; WISTAR RAT;

ANIMALS; ARISTOLOCHIC ACIDS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; KIDNEY DISEASES; MALE; METABOLIC DETOXICATION, DRUG; METHYLATION; MICE; MICE, INBRED C3H; RATS; RATS, WISTAR;

EID: 77955477610     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25141     Document Type: Article

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