The patterns of mutation and amplification of Plasmodium falciparum pfcrt and pfmdr1 genes in Thailand during the year 1988 to 2003

Parasitology Research

Volumn 107, Issue 3, 2010, Pages 539-545

  Mungthin, Mathirut ^a   Suwandittakul, Nantana ^b   Chaijaroenkul, Wanna ^b   Rungsrihirunrat, Kanchana ^c   Harnyuttanakorn, Pongchai ^c   Seugorn, Aree ^c   Na Bangchang, Kesara ^b  

^a PHRAMONGKUTKLAO HOSPITAL   (Thailand)

^b THAMMASAT UNIVERSITY   (Thailand)

^c CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CHLOROQUINE; CHLOROQUINE RESISTANCE PROTEIN; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN 1; QUININE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SENSITIVITY; GENE AMPLIFICATION; GENE DOSAGE; GENE MUTATION; GENOTYPE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PREVALENCE; PRIORITY JOURNAL; THAILAND; TREND STUDY; WILD TYPE;

ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; GENE DOSAGE; HUMANS; MALARIA, FALCIPARUM; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTOZOAN PROTEINS; THAILAND;

PLASMODIUM FALCIPARUM;

EID: 77955471359     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-010-1887-x     Document Type: Article

References (39)

1. IS Adagu DC Warhurst D Carucci MT Duraisingh 1995 Antimalarial drug response of Plasmodium falciparum from Zaria, Nigeria Trans R Soc Trop Med Hyg 89 442 445 10.1016/0035-9203(95)90037-3
2. AP Alker P Lim R Sem NK Shah P Yi DM Bouth R Tsuyuoka JD Maguire T Fandeur F Ariey C Wongsrichanalai 2007 Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border Am J Trop Med Hyg 76 641 647 1:CAS:528:DC%2BD2sXltFSqt78%3D 17426163
3. TJ Anderson S Nair H Qin S Singlam A Brockman L Paiphun F Nosten 2005 Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr1) associated with antimalarial drug resistance? Antimicrob Agents Chemother 49 2180 2188 10.1128/AAC.49.6.2180-2188.2005 1:CAS:528:DC%2BD2MXkvFChurc%3D 15917511 (Pubitemid 40734444)
4. LK Basco J Le Bras Z Rhoades CM Wilson 1995 Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from sub-Saharan Africa Mol Biochem Parasitol 74 157 166 10.1016/0166-6851(95)02492-1 1:CAS:528:DyaK2MXhtVSgtLnI 8719157 (Pubitemid 26024474)
5. C Cerutti Jr AC Marques FEC de Alencar RR Durlacher A Alween AAC Segurado L Pang MG Zalis 1999 Antimalarial drug susceptibility testing of Plasmodium falciparum in Brazil using a radioisotope method Mem Inst Oswaldo Cruz 94 803 809
6. SC Chaiyaroj A Buranakiti P Angkasekwinai S Looressuwan AF Cowman 1999 Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand Am J Trop Med Hyg 61 780 783 1:CAS:528:DyaK1MXotVertLs%3D 10586912
7. N Chen B Russell J Staley B Kotecka P Nasveld Q Cheng 2001 Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum J Infect Dis 183 1543 1545 10.1086/320206 1:STN:280:DC%2BD3M3jtFWisg%3D%3D 11319698
8. N Chen DE Kyle C Pasay EV Fowler J Baker JM Peters Q Cheng 2003 Pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines Antimicrob Agents Chemother 47 3500 3505 10.1128/AAC.47.11.3500-3505.2003 1:CAS:528:DC%2BD3sXovVait7g%3D 14576108 (Pubitemid 37345710)
9. K Congpuong K Na Bangchang M Mungthin P Bualombai WH Wernsdorfer 2005 Molecular epidemiology of drug resistance markers of Plasmodium falciparum malaria in Thailand Trop Med Int Health 10 717 722 10.1111/j.1365-3156.2005. 01450.x 1:CAS:528:DC%2BD2MXhtVWjtb%2FL 16045457 (Pubitemid 41098138)
10. RA Cooper MT Ferdig XZ Su LM Ursos J Mu T Nomura H Fujioka DA Fidock PD Roepe TE Wellems 2002 Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum Mol Pharmacol 61 35 42 10.1124/mol.61.1.35 1:CAS:528:DC%2BD38XltlSn 11752204 (Pubitemid 34049510)
11. RA Cooper KD Lane B Deng J Mu JJ Patel TE Wellems X Su MT Ferdig 2007 Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine Mol Microbiol 63 270 280 10.1111/j.1365-2958.2006.05511.x 1:CAS:528:DC%2BD2sXhsVyisbw%3D 17163969 (Pubitemid 44968124)
12. RE Desjardins CJ Canfield JD Haynes JD Chulay 1979 Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique Antimicrob Agents Chemother 16 710 718 1:CAS:528:DyaL3cXktFyrsL0%3D 394674
13. A Djimde OK Doumbo JF Cortese K Kayentao S Doumbo Y Diourte A Dicko XZ Su T Nomura DA Fidock TE Wellems CV Plowe D Coulibaly 2001 A molecular marker for chloroquine-resistant falciparum malaria N Engl J Med 344 257 263 10.1056/NEJM200101253440403 1:CAS:528:DC%2BD3MXht1Srur0%3D 11172152 (Pubitemid 32108530)
14. MT Duraisingh AF Cowman 2005 Contribution of the pfmdr 1 gene to antimalarial drug-resistance Acta Trop 94 181 190 1:CAS:528:DC%2BD2MXks1agtL8%3D 15876420
15. MT Duraisingh P Jones I Sambou L von Seidlein M Pinder DC Warhurst 2000 The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisisnin Mol Biochem Parasitol 108 13 23 10.1016/S0166-6851(00)00201-2 1:CAS:528:DC%2BD3cXjtVCisr0%3D 10802315 (Pubitemid 30236312)
16. V Durrand A Berry R Sem P Glaziou J Beaudou T Fandeur 2004 Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro Mol Biochem Parasitol 136 273 285 10.1016/j.molbiopara.2004.03.016 1:CAS:528:DC%2BD2cXkvV2jtLo%3D 15478806 (Pubitemid 38757996)
17. MT Ferdig RA Cooper J Mu B Deng DA Joy XZ Su TE Wellems 2004 Dissecting the loci of low-level quinine resistance in malaria parasites Mol Microbiol 52 985 997 10.1111/j.1365-2958.2004.04035.x 1:CAS:528:DC%2BD2cXktlKktro%3D 15130119 (Pubitemid 38916169)
18. DA Fidock T Nomura AK Talley RA Cooper SM Dzekunov MT Ferdig LM Ursos AB Sidhu B Naude KW Deitsch XZ Su JC Wootton PD Roepe TE Wellems 2000 Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance Mol Cell 6 861 871 10.1016/S1097-2765(05) 00077-8 1:CAS:528:DC%2BD3cXnvVegtbg%3D 11090624
19. I Hastings E Korenromp P Bloland 2007 The anatomy of a malaria disaster: drug policy choice and mortality in African children Lancet Infect Dis 7 739 748 10.1016/S1473-3099(07)70214-1 17884732 (Pubitemid 47610756)
20. DJ Johnson DA Fidock M Mungthin V Lakshmanan AB Sidhu PG Bray SA Ward 2004 Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents Mol Cell 15 867 877 10.1016/j.molcel.2004.09.012 1:CAS:528:DC%2BD2cXosl2jsbw%3D 15383277 (Pubitemid 39277984)
21. Malaria Division (1998) Malaria Control Programme in Thailand. In.: Malaria Division, Department of Communicable Disease Control (CDC) of the Ministry of Public Health, Thailand
22. J Mu MT Ferdig X Feng DA Joy J Duan T Furuya G Subramanian L Aravind RA Cooper JC Wootton M Xiong XZ Su 2003 Multiple transporters associated with malaria parasite responses to chloroquine and quinine Mol Microbiol 49 977 989 10.1046/j.1365-2958.2003.03627.x 1:CAS:528:DC%2BD3sXmslKltLg%3D 12890022 (Pubitemid 36981343)
23. AL Nelson A Purfield P McDaniel N Uthaimongkol N Buathong S Sriwichai RS Miller C Wongsrichanalai SR Meshnick 2005 Pfmdr 1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border Am J Trop Med Hyg 72 586 592 1:CAS:528:DC%2BD2MXltV2qtLs%3D 15891133
24. AL Pickard C Wongsrichanalai A Purfield D Kamwendo K Emery C Zalewski F Kawamoto RS Miller SR Meshnick 2003 Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr 1 Antimicrob Agents Chemother 47 2418 2423 10.1128/AAC.47.8.2418-2423.2003 1:CAS:528:DC%2BD3sXlvFCmurs%3D 12878499 (Pubitemid 36919439)
25. RN Price C Cassar A Brockman M Duraisingh M Van Vugt NJ White F Nosten S Krishna 1999 The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand Antimicrob Agents Chemother 43 2943 2949 1:CAS:528:DyaK1MXnvVCqtrw%3D 10582887
26. RN Price AC Uhlemann A Brockman R McGready E Ashley L Phaipun R Patel K Laing S Looareesuwan NJ White F Nosten S Krishna 2004 Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number Lancet 364 438 447 10.1016/S0140-6736(04)16767-6 1:CAS:528:DC%2BD2cXmt1Wjurs%3D 15288742 (Pubitemid 39036891)
27. RN Price AC Uhlemann M Wan Vugt A Brockman R Hutagalung S Nair D Nash P Singhasivanon TJ Anderson S Krishna NJ White F Nosten 2006 Molecular and pharmacological determinants of the therapeutic response to artemether- lumefantrine in multidrug-resistant Plasmodium falciparum malaria Clin Infect Dis 42 1570 1577 10.1086/503423 1:CAS:528:DC%2BD28XlvVOrsr8%3D 16652314
28. MB Reed KJ Saliba SR Caruana K Kirk AF Cowman 2000 Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum Nature 403 906 909 10.1038/35002615 1:CAS:528:DC%2BD3cXhs1Ors7o%3D 10706290 (Pubitemid 30130994)
29. AB Sidhu SG Valderramos DA Fidock 2005 Pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum Mol Microbiol 57 913 926 10.1111/j.1365-2958.2005.04729.x 1:CAS:528:DC%2BD2MXpsFCltb4%3D 16091034 (Pubitemid 41139856)
30. AB Sidhu AC Uhlemann SG Valderramos JC Valderramos S Krishna DA Fidock 2006 Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin J Infect Dis 194 528 535 10.1086/507115 16845638 (Pubitemid 44162666)
31. S Thaithong GH Beale B Fenton J McBride V Rosario A Walker D Walliker 1984 Clonal diversity in a single isolate of the malaria parasitePlasmodium falciparum Trans R Soc Trop Med Hyg 78 2 242 245 10.1016/0035-9203(84)90287-6 1:STN:280:DyaL2c3nsFCqtw%3D%3D 6380016
32. W Trager JB Jensen 1976 Human malaria parasites in continuous culture Science 193 673 675 10.1126/science.781840 1:STN:280:DyaE283ks1Wqug%3D%3D 781840
33. HH Van Es H Renkema H Aerts E Schurr 1994 Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr1 gene Mol Biochem Parasitol 68 209 219 10.1016/0166- 6851(94)90166-X 7739667
34. CM Wilson SK Volkman S Thaithong SK Martin DE Kyle WK Milhous DF Wirth 1993 Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand Mol Biochem Parasitol 57 151 160 10.1016/0166-6851(93)90252-S 1:CAS:528:DyaK3sXlslGjsLg%3D 8426608
35. C Wongsrichanalai J Sirichaisinthop JJ Karwacki K Congpuong RS Miller L Pang K Thimasarn 2001 Drug resistant malaria on the Thai-Myanmar and Thai-Cambodian borders Southeast Asian J Trop Med Public Health 32 41 49 1:STN:280:DC%2BD38%2FislOmtA%3D%3D 11485094
36. C Wongsrichanalai AL Pickard WH Wernsdorfer SR Meshnick 2002 Epidemiology of drug-resistant malaria Lancet Infect Dis 2 209 218 10.1016/S1473-3099(02) 00239-6 1:CAS:528:DC%2BD38Xjtlent78%3D 11937421 (Pubitemid 34464751)
37. J Wooden S Kyes CH Sibley 1993 PCR and strain identification in Plasmodium falciparum Parasitol Today 9 303 305 10.1016/0169-4758(93)90131-X 1:CAS:528:DyaK3sXmtFyntLY%3D 15463789 (Pubitemid 23217730)
38. S Zakeri M Afsharpad T Kazemzadeh K Mehdizadeh A Shabani ND Djadid 2008 Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum Am J Trop Med Hyg 78 633 640 1:CAS:528:DC%2BD1cXlsVCjtb4%3D 18385361
39. MG Zalis L Pang MS Silveira WK Milhous DF Wirth 1998 Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance Am J Trop Med Hyg 58 630 637 1:CAS:528:DyaK1cXjsVyltbw%3D 9598453