-
1
-
-
0036148405
-
Development of bisphosphonates
-
H. Fleisch Development of bisphosphonates Breast Cancer Res 4 2002 30 34
-
(2002)
Breast Cancer Res
, vol.4
, pp. 30-34
-
-
Fleisch, H.1
-
3
-
-
0014684354
-
Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
-
H. Fleisch, R.G. Russell, and M.D. Francis Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo Science 165 1969 1262 1264
-
(1969)
Science
, vol.165
, pp. 1262-1264
-
-
Fleisch, H.1
Russell, R.G.2
Francis, M.D.3
-
4
-
-
0019483875
-
Inhibition by two diphosphonates of bone lysis in tumor-conditioned media
-
A. Jung, B. Mermillod, C. Barras, M. Baud, and B. Courvoisier Inhibition by two diphosphonates of bone lysis in tumor-conditioned media Cancer Res 41 1981 3233 3237
-
(1981)
Cancer Res
, vol.41
, pp. 3233-3237
-
-
Jung, A.1
Mermillod, B.2
Barras, C.3
Baud, M.4
Courvoisier, B.5
-
5
-
-
0020505982
-
The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat Leydig cell tumor
-
R.R. Martodam, K.S. Thornton, D.A. Sica, S.M. D'Souza, L. Flora, and G.R. Mundy The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat Leydig cell tumor Calcif Tissue Int 35 1983 512 519
-
(1983)
Calcif Tissue Int
, vol.35
, pp. 512-519
-
-
Martodam, R.R.1
Thornton, K.S.2
Sica, D.A.3
D'Souza, S.M.4
Flora, L.5
Mundy, G.R.6
-
6
-
-
66349083394
-
The development of bisphosphonates for therapeutic uses, and bisphosphonate structure-activity consideration
-
W.M. Ahdou, and A.A. Shaddy The development of bisphosphonates for therapeutic uses, and bisphosphonate structure-activity consideration ARKIVOC 2009 2008 143 182
-
(2008)
ARKIVOC
, vol.2009
, pp. 143-182
-
-
Ahdou, W.M.1
Shaddy, A.A.2
-
7
-
-
33646080124
-
Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy
-
C.T. Leu, E. Luegmayr, L.P. Freedman, G.A. Rodan, and A.A. Reszka Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy Bone 38 2006 628 636
-
(2006)
Bone
, vol.38
, pp. 628-636
-
-
Leu, C.T.1
Luegmayr, E.2
Freedman, L.P.3
Rodan, G.A.4
Reszka, A.A.5
-
8
-
-
67650557310
-
Thermodynamics of bisphosphonates binding to human bone: A two-site model
-
S. Mukherjee, C. Huang, F. Guerra, K. Wang, and E. Oldfield Thermodynamics of bisphosphonates binding to human bone: a two-site model J Am Chem Soc 131 2009 8374 8375
-
(2009)
J Am Chem Soc
, vol.131
, pp. 8374-8375
-
-
Mukherjee, S.1
Huang, C.2
Guerra, F.3
Wang, K.4
Oldfield, E.5
-
9
-
-
0030227986
-
Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones
-
P. Masarachia, M. Weinreb, R. Balena, and G.A. Rodan Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones Bone 19 1996 281 290
-
(1996)
Bone
, vol.19
, pp. 281-290
-
-
Masarachia, P.1
Weinreb, M.2
Balena, R.3
Rodan, G.A.4
-
10
-
-
34547962875
-
Enhanced ability of dendritic cells to stimulate innate and adaptive immunity upon short-term incubation with zoledronic acid
-
F. Fiore, B. Castella, B. Nuschak, R. Bertieri, S. Mariani, and B. Bruno, et al. Enhanced ability of dendritic cells to stimulate innate and adaptive immunity upon short-term incubation with zoledronic acid Blood 110 2007 921 927
-
(2007)
Blood
, vol.110
, pp. 921-927
-
-
Fiore, F.1
Castella, B.2
Nuschak, B.3
Bertieri, R.4
Mariani, S.5
Bruno, B.6
-
11
-
-
0035360867
-
The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases
-
T. Hiraga, P.J. Williams, G.R. Mundy, and T. Yoneda The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases Cancer Res 61 2001 4418 4424
-
(2001)
Cancer Res
, vol.61
, pp. 4418-4424
-
-
Hiraga, T.1
Williams, P.J.2
Mundy, G.R.3
Yoneda, T.4
-
12
-
-
0034660687
-
Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
-
V. Kunzmann, E. Bauer, J. Feurle, F. Weissinger, H.P. Tony, and M. Wilhelm Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma Blood 96 2000 384 392
-
(2000)
Blood
, vol.96
, pp. 384-392
-
-
Kunzmann, V.1
Bauer, E.2
Feurle, J.3
Weissinger, F.4
Tony, H.P.5
Wilhelm, M.6
-
13
-
-
78650051896
-
Zoledronic acid repolarizes tumor-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway
-
Epub 2009 October 10, 10.1111/j.1582-4934.2009.00926.x. Available from:
-
Coscia M, Quaglino E, Iezzi M, et al. Zoledronic acid repolarizes tumor-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. J Cell Mol Med. Epub 2009 October 10, 10.1111/j.1582-4934.2009.00926.x. Available from: http://www.wiley.com/bw/ journal.asp?ref=1582-1838.
-
J Cell Mol Med
-
-
Coscia, M.1
Quaglino, E.2
Iezzi, M.3
-
14
-
-
70349326303
-
Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen
-
P. Vantourout, J. Mookerjee-Basu, and C. Rolland, et al. Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen J Immunol 183 2009 3848 3857
-
(2009)
J Immunol
, vol.183
, pp. 3848-3857
-
-
Vantourout, P.1
Mookerjee-Basu, J.2
Rolland, C.3
-
15
-
-
77149122603
-
Influence of zoledronic acid on disseminated tumor cells (DTC) in primary breast cancer patients
-
E. Solomayer, G. Gebauer, and P. Hirnle, et al. Influence of zoledronic acid on disseminated tumor cells (DTC) in primary breast cancer patients Cancer Res 69 2008 170s 171s
-
(2008)
Cancer Res
, vol.69
-
-
Solomayer, E.1
Gebauer, G.2
Hirnle, P.3
-
16
-
-
41949092083
-
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
-
F.P. Coxon, K. Thompson, A.J. Roelofs, F.H. Ebetino, and M.J. Rogers Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells Bone 42 2008 848 860
-
(2008)
Bone
, vol.42
, pp. 848-860
-
-
Coxon, F.P.1
Thompson, K.2
Roelofs, A.J.3
Ebetino, F.H.4
Rogers, M.J.5
-
17
-
-
33645814413
-
Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis
-
K. Thompson, M.J. Rogers, F.P. Coxon, and J.C. Crockett Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis Mol Pharmacol 69 2006 1624 1632
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1624-1632
-
-
Thompson, K.1
Rogers, M.J.2
Coxon, F.P.3
Crockett, J.C.4
-
18
-
-
0030895688
-
Trafficking of matrix collagens through bone-resorbing osteoclasts
-
S.A. Nesbitt, and M.A. Horton Trafficking of matrix collagens through bone-resorbing osteoclasts Science 276 1997 266 269
-
(1997)
Science
, vol.276
, pp. 266-269
-
-
Nesbitt, S.A.1
Horton, M.A.2
-
19
-
-
77953396505
-
Fluorescent risedronate analogs reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
-
E-pub 2009 October 12, 10.1359/jbmr.091009. Available from:
-
Roelofs AJ, Coxon FP, Ebetino FH, et al. Fluorescent risedronate analogs reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. J Bone Miner Res. E-pub 2009 October 12, 10.1359/jbmr.091009. Available from: http://www.jbmr.org/view/0/index.html.
-
J Bone Miner Res
-
-
Roelofs, A.J.1
Coxon, F.P.2
Ebetino, F.H.3
-
20
-
-
0031754521
-
Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: Evidence from structure-activity relationships in J774 macrophages
-
S.P. Luckman, F.P. Coxon, F.H. Ebetino, R.G. Russell, and M.J. Rogers Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages J Bone Miner Res 13 1998 1668 1678
-
(1998)
J Bone Miner Res
, vol.13
, pp. 1668-1678
-
-
Luckman, S.P.1
Coxon, F.P.2
Ebetino, F.H.3
Russell, R.G.4
Rogers, M.J.5
-
21
-
-
0031977199
-
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
-
S.P. Luckman, D.E. Hughes, F.P. Coxon, R. Graham, G. Russell, and M.J. Rogers Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras J Bone Miner Res 13 1998 581 589
-
(1998)
J Bone Miner Res
, vol.13
, pp. 581-589
-
-
Luckman, S.P.1
Hughes, D.E.2
Coxon, F.P.3
Graham, R.4
Russell, G.5
Rogers, M.J.6
-
22
-
-
33644539542
-
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
-
H. Monkkonen, S. Auriola, and P. Lehenkari, et al. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates Br J Pharmacol 147 2006 437 445
-
(2006)
Br J Pharmacol
, vol.147
, pp. 437-445
-
-
Monkkonen, H.1
Auriola, S.2
Lehenkari, P.3
-
23
-
-
1542275565
-
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
-
D.J. Hosfield, Y. Zhang, and D.R. Dougan, et al. Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J Biol Chem 279 2004 8526 8529
-
(2004)
J Biol Chem
, vol.279
, pp. 8526-8529
-
-
Hosfield, D.J.1
Zhang, Y.2
Dougan, D.R.3
-
24
-
-
33646725498
-
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
-
K.L. Kavanagh, K. Guo, and J.E. Dunford, et al. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Proc Natl Acad Sci U S A 103 2006 7829 7834
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7829-7834
-
-
Kavanagh, K.L.1
Guo, K.2
Dunford, J.E.3
-
25
-
-
41849123834
-
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthase
-
J.E. Dunford, A.A. Kwaasi, and M.J. Rogers, et al. Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase J Med Chem 51 2008 2187 2195
-
(2008)
J Med Chem
, vol.51
, pp. 2187-2195
-
-
Dunford, J.E.1
Kwaasi, A.A.2
Rogers, M.J.3
-
26
-
-
33646367241
-
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs
-
J.M. Rondeau, F. Bitsch, and E. Bourgier, et al. Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs Chem Med Chem 1 2006 267 273
-
(2006)
Chem Med Chem
, vol.1
, pp. 267-273
-
-
Rondeau, J.M.1
Bitsch, F.2
Bourgier, E.3
-
27
-
-
33645638181
-
Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells
-
M. Goffinet, M. Thoulouzan, and A. Pradines, et al. Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells BMC Cancer 6 2006 60
-
(2006)
BMC Cancer
, vol.6
, pp. 60
-
-
Goffinet, M.1
Thoulouzan, M.2
Pradines, A.3
-
28
-
-
33646269011
-
Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases
-
J.E. Dunford, M.J. Rogers, F.H. Ebetino, R.J. Phipps, and F.P. Coxon Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases J Bone Miner Res 21 2006 684 694
-
(2006)
J Bone Miner Res
, vol.21
, pp. 684-694
-
-
Dunford, J.E.1
Rogers, M.J.2
Ebetino, F.H.3
Phipps, R.J.4
Coxon, F.P.5
-
29
-
-
34547231214
-
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
-
R.T. Guo, R. Cao, and P.H. Liang, et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc Natl Acad Sci U S A 104 2007 10022 10027
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10022-10027
-
-
Guo, R.T.1
Cao, R.2
Liang, P.H.3
-
30
-
-
69749110704
-
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro
-
J. Raikkonen, J.C. Crockett, M.J. Rogers, H. Monkkonen, S. Auriola, and J. Monkkonen Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro Br J Pharmacol 157 2009 427 435
-
(2009)
Br J Pharmacol
, vol.157
, pp. 427-435
-
-
Raikkonen, J.1
Crockett, J.C.2
Rogers, M.J.3
Monkkonen, H.4
Auriola, S.5
Monkkonen, J.6
-
31
-
-
76249086684
-
Lysosomal-mitochondrial axis in zoledronic acid induced apoptosis in human follicular lymphoma cells
-
L.M. Mitrofan, F.B. Castells, J. Pelkonen, and J. Monkkonen Lysosomal-mitochondrial axis in zoledronic acid induced apoptosis in human follicular lymphoma cells J Biol Chem 285 2010 1967 1979
-
(2010)
J Biol Chem
, vol.285
, pp. 1967-1979
-
-
Mitrofan, L.M.1
Castells, F.B.2
Pelkonen, J.3
Monkkonen, J.4
-
32
-
-
0036788379
-
Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin
-
A. Shiotani, M. Takami, K. Itoh, Y. Shibasaki, and T. Sasaki Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin Anat Rec 268 2002 137 146
-
(2002)
Anat Rec
, vol.268
, pp. 137-146
-
-
Shiotani, A.1
Takami, M.2
Itoh, K.3
Shibasaki, Y.4
Sasaki, T.5
-
33
-
-
46049108371
-
Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway
-
E. Chamoux, N. Houde, K. L'Eriger, and S. Roux Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway J Cell Physiol 216 2008 536 542
-
(2008)
J Cell Physiol
, vol.216
, pp. 536-542
-
-
Chamoux, E.1
Houde, N.2
L'Eriger, K.3
Roux, S.4
-
34
-
-
35748946639
-
Investigating the interaction between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: Evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways
-
S. Vitovski, J.S. Phillips, J. Sayers, and P.I. Croucher Investigating the interaction between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways J Biol Chem 282 2007 31601 31609
-
(2007)
J Biol Chem
, vol.282
, pp. 31601-31609
-
-
Vitovski, S.1
Phillips, J.S.2
Sayers, J.3
Croucher, P.I.4
-
35
-
-
77049089989
-
A double-blind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
-
abstract
-
D. Henry, R. von Moos, and S. Vadhan-Raj, et al. A double-blind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma [abstract] Eur J Cancer Suppl 7 2009 12
-
(2009)
Eur J Cancer Suppl
, vol.7
, pp. 12
-
-
Henry, D.1
Von Moos, R.2
Vadhan-Raj, S.3
-
36
-
-
72149124320
-
Denosumab versus zoledronic acid for the treatment of breast cancer patients with bone metastases: Results of a randomized phase 3 study
-
abstract
-
A. Stopeck, J.J. Body, and Y. Fujiwara, et al. Denosumab versus zoledronic acid for the treatment of breast cancer patients with bone metastases: results of a randomized phase 3 study [abstract] Eur J Cancer Suppl (Meeting Abstracts) 7 2009 2
-
(2009)
Eur J Cancer Suppl (Meeting Abstracts)
, vol.7
, pp. 2
-
-
Stopeck, A.1
Body, J.J.2
Fujiwara, Y.3
-
37
-
-
3042843179
-
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE)
-
B. Pan, A.N. Farrugia, and L.B. To, et al. The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE) J Bone Miner Res 19 2004 147 154
-
(2004)
J Bone Miner Res
, vol.19
, pp. 147-154
-
-
Pan, B.1
Farrugia, A.N.2
To, L.B.3
-
38
-
-
0036295812
-
Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts
-
V. Viereck, G. Emons, and V. Lauck, et al. Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts Biochem Biophys Res Commun 291 2002 680 686
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 680-686
-
-
Viereck, V.1
Emons, G.2
Lauck, V.3
-
39
-
-
72049100087
-
Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells
-
T.D. Rachner, S.K. Singh, and M. Schoppet, et al. Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells Cancer Lett 287 2010 109 116
-
(2010)
Cancer Lett
, vol.287
, pp. 109-116
-
-
Rachner, T.D.1
Singh, S.K.2
Schoppet, M.3
-
40
-
-
0033596124
-
Aberrant rel/nfkb genes and activity in human cancer
-
B. Rayet, and C. Gelinas Aberrant rel/nfkb genes and activity in human cancer Oncogene 18 1999 6938 6947
-
(1999)
Oncogene
, vol.18
, pp. 6938-6947
-
-
Rayet, B.1
Gelinas, C.2
-
41
-
-
68349160814
-
Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis
-
M. Korpal, J. Yan, X. Lu, S. Xu, D.A. Lerit, and Y. Kang Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis Nat Med 15 2009 960 966
-
(2009)
Nat Med
, vol.15
, pp. 960-966
-
-
Korpal, M.1
Yan, J.2
Lu, X.3
Xu, S.4
Lerit, D.A.5
Kang, Y.6
-
43
-
-
76249119723
-
Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
-
N. Bivi, M. Romanello, and R. Harrison, et al. Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection Genome Biol 10 2009 R93
-
(2009)
Genome Biol
, vol.10
-
-
Bivi, N.1
Romanello, M.2
Harrison, R.3
-
44
-
-
73449089472
-
Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells
-
X. Tang, Q. Zhang, and S. Shi, et al. Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells Int J Cancer 126 2010 90 103
-
(2010)
Int J Cancer
, vol.126
, pp. 90-103
-
-
Tang, X.1
Zhang, Q.2
Shi, S.3
-
46
-
-
70249139162
-
Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells
-
M. Marra, D. Santini, and G. Meo, et al. Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells Int J Cancer 125 2009 2004 2013
-
(2009)
Int J Cancer
, vol.125
, pp. 2004-2013
-
-
Marra, M.1
Santini, D.2
Meo, G.3
-
47
-
-
0035051719
-
Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro
-
H.L. Benford, N.W. McGowan, M.H. Helfrich, M.E. Nuttall, and M.J. Rogers Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro Bone 28 2001 465 473
-
(2001)
Bone
, vol.28
, pp. 465-473
-
-
Benford, H.L.1
McGowan, N.W.2
Helfrich, M.H.3
Nuttall, M.E.4
Rogers, M.J.5
-
48
-
-
0030601220
-
Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes
-
M.J. Rogers, R.J. Brown, V. Hodkin, G.M. Blackburn, R.G. Russell, and D.J. Watts Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes Biochem Biophys Res Commun 224 1996 863 869
-
(1996)
Biochem Biophys Res Commun
, vol.224
, pp. 863-869
-
-
Rogers, M.J.1
Brown, R.J.2
Hodkin, V.3
Blackburn, G.M.4
Russell, R.G.5
Watts, D.J.6
-
49
-
-
1842405434
-
Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro
-
J.C. Frith, J. Monkkonen, G.M. Blackburn, R.G. Russell, and M.J. Rogers Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro J Bone Miner Res 12 1997 1358 1367
-
(1997)
J Bone Miner Res
, vol.12
, pp. 1358-1367
-
-
Frith, J.C.1
Monkkonen, J.2
Blackburn, G.M.3
Russell, R.G.4
Rogers, M.J.5
-
50
-
-
0034926222
-
Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice
-
D.R. Clohisy, P.F. O'Keefe, and M.L. Ramnaraine Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice J Orthop Res 19 2001 554 558
-
(2001)
J Orthop Res
, vol.19
, pp. 554-558
-
-
Clohisy, D.R.1
O'Keefe, P.F.2
Ramnaraine, M.L.3
-
51
-
-
0036138734
-
Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: The role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors
-
E.R. Van Beek, C.W. Lowik, and S.E. Papapoulos Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors Bone 30 2002 64 70
-
(2002)
Bone
, vol.30
, pp. 64-70
-
-
Van Beek, E.R.1
Lowik, C.W.2
Papapoulos, S.E.3
-
52
-
-
33746768764
-
Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs
-
L.I. Plotkin, S.C. Manolagas, and T. Bellido Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs Bone 39 2006 443 452
-
(2006)
Bone
, vol.39
, pp. 443-452
-
-
Plotkin, L.I.1
Manolagas, S.C.2
Bellido, T.3
-
53
-
-
54249141694
-
Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo
-
L.I. Plotkin, V. Lezcano, J. Thostenson, R.S. Weinstein, S.C. Manolagas, and T. Bellido Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo J Bone Miner Res 23 2008 1712 1721
-
(2008)
J Bone Miner Res
, vol.23
, pp. 1712-1721
-
-
Plotkin, L.I.1
Lezcano, V.2
Thostenson, J.3
Weinstein, R.S.4
Manolagas, S.C.5
Bellido, T.6
-
54
-
-
0037029682
-
The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells
-
S.G. Senaratne, J.L. Mansi, and K.W. Colston The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells Br J Cancer 86 2002 1479 1486
-
(2002)
Br J Cancer
, vol.86
, pp. 1479-1486
-
-
Senaratne, S.G.1
Mansi, J.L.2
Colston, K.W.3
-
55
-
-
73549086519
-
Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model
-
Ottewell PD, Lefley DV, Cross SS, Evans CA, Coleman RE, Holen I. Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model. Int J Cancer. 126:522-32.
-
Int J Cancer
, vol.126
, pp. 522-532
-
-
Ottewell, P.D.1
Lefley, D.V.2
Cross, S.S.3
Evans, C.A.4
Coleman, R.E.5
Holen, I.6
-
56
-
-
0036569635
-
Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway
-
S.S. Virtanen, H.K. Vaananen, P.L. Harkonen, and P.T. Lakkakorpi Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway Cancer Res 62 2002 2708 2714
-
(2002)
Cancer Res
, vol.62
, pp. 2708-2714
-
-
Virtanen, S.S.1
Vaananen, H.K.2
Harkonen, P.L.3
Lakkakorpi, P.T.4
-
57
-
-
0032404144
-
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway
-
C.M. Shipman, P.I. Croucher, R.G. Russell, M.H. Helfrich, and M.J. Rogers The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway Cancer Res 58 1998 5294 5297
-
(1998)
Cancer Res
, vol.58
, pp. 5294-5297
-
-
Shipman, C.M.1
Croucher, P.I.2
Russell, R.G.3
Helfrich, M.H.4
Rogers, M.J.5
-
58
-
-
71849102718
-
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells
-
J. Raikkonen, H. Monkkonen, S. Auriola, and J. Monkkonen Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells Biochem Pharmacol 79 2010 777 783
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 777-783
-
-
Raikkonen, J.1
Monkkonen, H.2
Auriola, S.3
Monkkonen, J.4
-
59
-
-
51049104872
-
The plasticity of gamma delta T cells: Innate immunity, antigen presentation and new immunotherapy
-
R. Casetti, and A. Martino The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy Cell Mol Immunol 5 2008 161 170
-
(2008)
Cell Mol Immunol
, vol.5
, pp. 161-170
-
-
Casetti, R.1
Martino, A.2
-
60
-
-
33745852256
-
Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens
-
Y. Kato, Y. Tanaka, M. Hayashi, K. Okawa, and N. Minato Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens J Immunol 177 2006 877 884
-
(2006)
J Immunol
, vol.177
, pp. 877-884
-
-
Kato, Y.1
Tanaka, Y.2
Hayashi, M.3
Okawa, K.4
Minato, N.5
-
61
-
-
20444445149
-
Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy
-
K. Sato, S. Kimura, and H. Segawa, et al. Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy Int J Cancer 116 2005 94 99
-
(2005)
Int J Cancer
, vol.116
, pp. 94-99
-
-
Sato, K.1
Kimura, S.2
Segawa, H.3
-
62
-
-
59449106667
-
Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model
-
T. Yuasa, K. Sato, and E. Ashihara, et al. Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model Cancer Immunol Immunother 58 2009 493 502
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 493-502
-
-
Yuasa, T.1
Sato, K.2
Ashihara, E.3
-
63
-
-
58149086028
-
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP
-
A.J. Roelofs, M. Jauhiainen, H. Monkkonen, M.J. Rogers, J. Monkkonen, and K. Thompson Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP Br J Haematol 144 2009 245 250
-
(2009)
Br J Haematol
, vol.144
, pp. 245-250
-
-
Roelofs, A.J.1
Jauhiainen, M.2
Monkkonen, H.3
Rogers, M.J.4
Monkkonen, J.5
Thompson, K.6
|