Synthesis and pharmacological evaluation of aryl aminosulfonamide derivatives as potent 5-HT 6 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4440-4443

  Nirogi, Ramakrishna V S ^a   Daulatabad, Anand V ^a   Parandhama, G ^a   Mohammad, Shaikh ^a   Sastri, K R ^a   Shinde, Anil K ^a   Dubey, P K ^b  

^a SUVEN LIFE SCIENCES LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

5 HT 6R; Cognition; Morris water maze; NORT

Indexed keywords

ARYL AMINOSULFONAMIDE DERIVATIVE; SEROTONIN 6 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COGNITION; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MAZE TEST; NONHUMAN; RAT; RECOGNITION; REPORTER GENE;

ANIMALS; COGNITION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; HUMANS; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

ANIMALIA;

EID: 77955432030     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.060     Document Type: Article

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