메뉴 건너뛰기




Volumn 33, Issue 7, 2010, Pages 1035-1041

Suppression of adipocyte differentiation by 15-methoxypinusolidic acid through inhibition of PPARγ activity

Author keywords

15 Methoxypinusolidic acid; Adipocyte differentiation; Pinusolide; PPAR

Indexed keywords

15 METHOXYPINUSOLIDIC ACID; DITERPENOID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

EID: 77955410474     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0709-0     Document Type: Article
Times cited : (8)

References (38)
  • 1
    • 17544396164 scopus 로고    scopus 로고
    • Activators of peroxisome proliferator-activated receptor gamma have depotspecific effects on human preadipocyte differentiation
    • 10.1172/JCI119870 1:CAS:528:DyaK2sXotVyrs7s%3D 9399962
    • M. Adams C. T. Montague J. B. Prins J. C. Holder S. A. Smith L. Sanders J. E. Digby C. P. Sewter M. A. Lazar V. K. Chatterjee S. O'Rahilly 1997 Activators of peroxisome proliferator-activated receptor gamma have depotspecific effects on human preadipocyte differentiation J. Clin. Invest. 100 3149 3153 10.1172/JCI119870 1:CAS:528:DyaK2sXotVyrs7s%3D 9399962
    • (1997) J. Clin. Invest. , vol.100 , pp. 3149-3153
    • Adams, M.1    Montague, C.T.2    Prins, J.B.3    Holder, J.C.4    Smith, S.A.5    Sanders, L.6    Digby, J.E.7    Sewter, C.P.8    Lazar, M.A.9    Chatterjee, V.K.10    O'Rahilly, S.11
  • 2
    • 0043234630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect
    • DOI 10.1074/jbc.M304654200
    • M. Armoni N. Kritz C. Harel F. Bar-Yoseph H. Chen M. J. Quon E. Karnieli 2003 Peroxisome proliferators-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect J. Biol. Chem. 278 30614 30623 10.1074/jbc.M304654200 1:CAS:528: DC%2BD3sXmtFeqs78%3D 12777391 (Pubitemid 36994566)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 30614-30623
    • Armoni, M.1    Kritz, N.2    Harel, C.3    Bar-Yoseph, F.4    Chen, H.5    Quon, M.J.6    Karnieli, E.7
  • 3
    • 0034106512 scopus 로고    scopus 로고
    • Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants
    • 10.1017/S002966510000015X 1:CAS:528:DC%2BD3cXktF2gsrY%3D 10828182
    • Y. Chilliard A. Ferlay Y. Faulconnier M. Bonnet J. Rouel F. Bocquier 2000 Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants Proc. Nutr. Soc. 59 127 134 10.1017/S002966510000015X 1:CAS:528:DC%2BD3cXktF2gsrY%3D 10828182
    • (2000) Proc. Nutr. Soc. , vol.59 , pp. 127-134
    • Chilliard, Y.1    Ferlay, A.2    Faulconnier, Y.3    Bonnet, M.4    Rouel, J.5    Bocquier, F.6
  • 4
    • 39949085423 scopus 로고    scopus 로고
    • A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: Implication for a potential anti-inflammatory effect
    • 10.1016/j.intimp.2007.12.010 1:CAS:528:DC%2BD1cXivFyksbs%3D 18328446
    • Y. Choi A. Moon Y. C. Kim 2008 A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: implication for a potential anti-inflammatory effect Int. Immunopharmacol. 8 548 555 10.1016/j.intimp.2007.12.010 1:CAS:528:DC%2BD1cXivFyksbs%3D 18328446
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 548-555
    • Choi, Y.1    Moon, A.2    Kim, Y.C.3
  • 5
    • 23644455127 scopus 로고    scopus 로고
    • PPARγ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1
    • DOI 10.1172/JCI24130
    • P. C. Chui H. P. Guan M. Lehrke M. A. Lazar 2005 PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1 J. Clin. Invest. 115 2244 2256 10.1172/JCI24130 1:CAS:528:DC%2BD2MXntFCmur4%3D 16007265 (Pubitemid 41134167)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.8 , pp. 2244-2256
    • Chui, P.C.1    Guan, H.-P.2    Lehrke, M.3    Lazar, M.A.4
  • 6
    • 0032054230 scopus 로고    scopus 로고
    • Transcriptional control of adipogenesis
    • DOI 10.1016/S0955-0674(98)80138-5
    • L. Fajas J. C. Fruchart J. Auwerx 1998 Transcriptional control of adipogenesis Curr. Opin. Cell Biol. 10 165 173 10.1016/S0955-0674(98)80138-5 1:CAS:528:DyaK1cXisFynt7c%3D 9561840 (Pubitemid 28174758)
    • (1998) Current Opinion in Cell Biology , vol.10 , Issue.2 , pp. 165-173
    • Fajas, L.1    Fruchart, J.-C.2    Auwerx, J.3
  • 7
    • 0016693548 scopus 로고
    • An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion
    • 10.1016/0092-8674(75)90087-2 1:CAS:528:DyaE2MXlt12gu7o%3D 165899
    • H. Green O. Kehinde 1975 An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion Cell 5 19 27 10.1016/0092-8674(75)90087-2 1:CAS:528:DyaE2MXlt12gu7o%3D 165899
    • (1975) Cell , vol.5 , pp. 19-27
    • Green, H.1    Kehinde, O.2
  • 8
    • 0017239088 scopus 로고
    • Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
    • 10.1016/0092-8674(76)90260-9 1:CAS:528:DyaE28XktFyju74%3D 949738
    • H. Green O. Kehinde 1976 Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells Cell 7 105 113 10.1016/0092-8674(76) 90260-9 1:CAS:528:DyaE28XktFyju74%3D 949738
    • (1976) Cell , vol.7 , pp. 105-113
    • Green, H.1    Kehinde, O.2
  • 9
    • 0003027380 scopus 로고    scopus 로고
    • In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: A structure-activity study
    • DOI 10.1021/jm970569j
    • B. H. Han H. O. Yang Y. H. Kang D. Y. Suh H. J. Go W. J. Song Y. C. Kim M. K. Park 1998 In vitro plateletactivating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study J. Med. Chem. 41 2626 2630 10.1021/jm970569j 1:CAS:528:DyaK1cXktlShurs%3D 9651167 (Pubitemid 28321912)
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.14 , pp. 2626-2630
    • Han, B.H.1    Yang, H.O.2    Kang, Y.-H.3    Suh, D.-Y.4    Go, H.J.5    Song, W.-J.6    Kim, Y.C.7    Park, M.K.8
  • 10
    • 0346880504 scopus 로고    scopus 로고
    • Inflammatory pathways and insulin action
    • DOI 10.1038/sj.ijo.0802502
    • G. S. Hotamisligil 2003 Inflammatory pathways and insulin action Int. J. Obes. Relat. Metab. Disord. 27 Suppl.3 S53 S55 10.1038/sj.ijo.0802502 1:CAS:528:DC%2BD2cXls1Ki 14704746 (Pubitemid 38019190)
    • (2003) International Journal of Obesity , vol.27 , Issue.SUPPL. 3
    • Hotamisligil, G.S.1
  • 11
    • 70349567378 scopus 로고    scopus 로고
    • Fat targets for skeletal health
    • 10.1038/nrrheum.2009.102 19468288
    • M. Kawai M. J. Devlin C. J. Rosen 2009 Fat targets for skeletal health Nat. Rev. Rheumatol. 5 365 372 10.1038/nrrheum.2009.102 19468288
    • (2009) Nat. Rev. Rheumatol. , vol.5 , pp. 365-372
    • Kawai, M.1    Devlin, M.J.2    Rosen, C.J.3
  • 12
    • 0033048977 scopus 로고    scopus 로고
    • Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist
    • 10.1055/s-1999-13959 1:CAS:528:DyaK1MXhsVSjtr4%3D 10083843
    • K. A. Kim T. C. Moon S. W. Lee K. C. Chung B. H. Han H. W. Chang 1999 Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist Planta Med. 65 39 42 10.1055/s-1999-13959 1:CAS:528: DyaK1MXhsVSjtr4%3D 10083843
    • (1999) Planta Med. , vol.65 , pp. 39-42
    • Kim, K.A.1    Moon, T.C.2    Lee, S.W.3    Chung, K.C.4    Han, B.H.5    Chang, H.W.6
  • 13
    • 0036597395 scopus 로고    scopus 로고
    • A new neuroprotective pinusolide derivative from the leaves of Biota orientalis
    • DOI 10.1248/cpb.50.834
    • K. A. Koo S. H. Sung Y. C. Kim 2002 A new neuroprotective pinusolide derivative from the leaves of Biota orientalis Chem. Pharm. Bull. 50 834 836 10.1248/cpb.50.834 1:CAS:528:DC%2BD38XkvFOltLs%3D 12045342 (Pubitemid 41694905)
    • (2002) Chemical and Pharmaceutical Bulletin , vol.50 , Issue.6 , pp. 834-836
    • Koo, K.A.1    Sung, S.H.2    Kim, Y.C.3
  • 14
    • 33745185534 scopus 로고    scopus 로고
    • 15-Methoxypinusolidic acid from Biota orientalis attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells
    • 10.1016/j.tiv.2006.02.001 1:CAS:528:DC%2BD28Xmt1Orurs%3D 16564156
    • K. A. Koo S. H. Kim M. K. Lee Y. C. Kim 2006 15-Methoxypinusolidic acid from Biota orientalis attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells Toxicol. In Vitro 20 936 941 10.1016/j.tiv.2006.02. 001 1:CAS:528:DC%2BD28Xmt1Orurs%3D 16564156
    • (2006) Toxicol. In Vitro , vol.20 , pp. 936-941
    • Koo, K.A.1    Kim, S.H.2    Lee, M.K.3    Kim, Y.C.4
  • 15
    • 33846219146 scopus 로고    scopus 로고
    • Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells
    • DOI 10.1038/sj.bjp.0706944, PII 0706944
    • K. A. Koo M. K. Lee S. H. Kim E. J. Jeong S. Y. Kim T. H. Oh Y. C. Kim 2007 Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells Br. J. Pharmacol. 150 65 71 10.1038/sj.bjp.0706944 1:CAS:528:DC%2BD2sXis1Kisg%3D%3D 17143305 (Pubitemid 46094670)
    • (2007) British Journal of Pharmacology , vol.150 , Issue.1 , pp. 65-71
    • Koo, K.A.1    Lee, M.K.2    Kim, S.H.3    Jeong, E.J.4    Kim, S.Y.5    Oh, T.H.6    Kim, Y.C.7
  • 16
    • 0021984010 scopus 로고
    • Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. V. On antihemorrhagic principle in Biota orientalis (L.) ENDL
    • T. Kosuge H. Ishida T. Satoh 1985 Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. V. On antihemorrhagic principle in Biota orientalis (L.) Endl Chem. Pharm. Bull. 33 206 209 1:CAS:528:DyaL2MXht1yrtLk%3D 4006015 (Pubitemid 15130850)
    • (1985) Chemical and Pharmaceutical Bulletin , vol.33 , Issue.1 , pp. 206-209
    • Kosuge, T.1    Ishida, H.2    Satoh, T.3
  • 17
    • 49749151335 scopus 로고    scopus 로고
    • Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells
    • 10.1007/s12272-001-1239-9 1:CAS:528:DC%2BD1cXovFWltr4%3D 18704328
    • M. K. Lee H. Yang J. S. Yoon E. J. Jeong Y. Kim do N. R. Ha S. H. Sung Y. C. Kim 2008 Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells Arch. Pharm. Res. 31 866 871 10.1007/s12272-001-1239-9 1:CAS:528:DC%2BD1cXovFWltr4%3D 18704328
    • (2008) Arch. Pharm. Res. , vol.31 , pp. 866-871
    • Lee, M.K.1    Yang, H.2    Yoon, J.S.3    Jeong, E.J.4    Kim Do, Y.5    Ha, N.R.6    Sung, S.H.7    Kim, Y.C.8
  • 18
    • 0029062839 scopus 로고
    • Transcriptional regulation of gene expression during adipocyte differentiation
    • 10.1146/annurev.bi.64.070195.002021 1:CAS:528:DyaK2MXmsl2qsbo%3D 7574486
    • O. A. MacDougald M. D. Lane 1995 Transcriptional regulation of gene expression during adipocyte differentiation Annu. Rev. Biochem. 64 345 373 10.1146/annurev.bi.64.070195.002021 1:CAS:528:DyaK2MXmsl2qsbo%3D 7574486
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 345-373
    • MacDougald, O.A.1    Lane, M.D.2
  • 19
    • 0036076907 scopus 로고    scopus 로고
    • Metabolic and additional vascular effects of thiazolidinediones
    • 10.2165/00003495-200262100-00004 1:CAS:528:DC%2BD38XmsVGlt78%3D 12093315
    • F. M. Martens F. L. Visseren J. Lemay E. J. de Koning T. J. Rabelink 2002 Metabolic and additional vascular effects of thiazolidinediones Drugs 62 1463 1480 10.2165/00003495-200262100-00004 1:CAS:528:DC%2BD38XmsVGlt78%3D 12093315
    • (2002) Drugs , vol.62 , pp. 1463-1480
    • Martens, F.M.1    Visseren, F.L.2    Lemay, J.3    De Koning, E.J.4    Rabelink, T.J.5
  • 20
    • 0036200822 scopus 로고    scopus 로고
    • Suppression of body fat accumulation in myostatin-deficient mice
    • 1:CAS:528:DC%2BD38XitVeqt7Y%3D 11877467
    • A. C. McPherron S. J. Lee 2002 Suppression of body fat accumulation in myostatin-deficient mice J. Clin. Invest. 109 595 601 1:CAS:528: DC%2BD38XitVeqt7Y%3D 11877467
    • (2002) J. Clin. Invest. , vol.109 , pp. 595-601
    • McPherron, A.C.1    Lee, S.J.2
  • 22
    • 2542491213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ in diabetes and metabolism
    • DOI 10.1016/j.tips.2004.03.012, PII S0165614704001154
    • S. M. Rangwala M. A. Lazar 2004 Peroxisome proliferators-activated receptor gamma in diabetes and metabolism Trends Pharmacol. Sci. 25 331 336 10.1016/j.tips.2004.03.012 1:CAS:528:DC%2BD2cXksVelsLk%3D 15165749 (Pubitemid 38692426)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.6 , pp. 331-336
    • Rangwala, S.M.1    Lazar, M.A.2
  • 23
    • 0141920726 scopus 로고    scopus 로고
    • Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity
    • DOI 10.1016/S1534-5807(03)00274-0, PII S1534580703002740
    • S. M. Rangwala B. Rhoades J. S. Shapiro A. S. Rich J. K. Kim G. I. Shulman K. H. Kaestner M. A. Lazar 2003 Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity Dev. Cell 5 657 663 10.1016/S1534-5807(03)00274-0 1:CAS:528:DC%2BD3sXotlWjsro%3D 14536066 (Pubitemid 37243053)
    • (2003) Developmental Cell , vol.5 , Issue.4 , pp. 657-663
    • Rangwala, S.M.1    Rhoades, B.2    Shapiro, J.S.3    Rich, A.S.4    Kim, J.K.5    Shulman, G.I.6    Kaestner, K.H.7    Lazar, M.A.8
  • 25
    • 33646873050 scopus 로고    scopus 로고
    • Adipocyte-derived hormones, cytokines, and mediators
    • DOI 10.1385/ENDO:29:1:81
    • C. M. Rondinone 2006 Adipocyte-derived hormones, cytokines, and mediators Endocrine 29 81 90 10.1385/ENDO:29:1:81 1:CAS:528:DC%2BD28XksFant70%3D 16622295 (Pubitemid 43780349)
    • (2006) Endocrine , vol.29 , Issue.1 , pp. 81-90
    • Rondinone, C.M.1
  • 26
    • 0036108485 scopus 로고    scopus 로고
    • Molecular mechanisms of adipocyte differentiation
    • 1:CAS:528:DC%2BD38XlsVyrs7s%3D
    • E. D. Rosen 2002 Molecular mechanisms of adipocyte differentiation Ann. Endocrinol. (Paris) 63 79 82 1:CAS:528:DC%2BD38XlsVyrs7s%3D
    • (2002) Ann. Endocrinol. (Paris) , vol.63 , pp. 79-82
    • Rosen, E.D.1
  • 27
    • 0033213631 scopus 로고    scopus 로고
    • PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
    • DOI 10.1016/S1097-2765(00)80211-7
    • E. D. Rosen P. Sarraf A. E. Troy G. Bradwin K. Moore D. S. Milstone B. M. Spiegelman R. M. Mortensen 1999 PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro Mol. Cell 4 611 617 10.1016/S1097- 2765(00)80211-7 1:CAS:528:DyaK1MXntFCgsb4%3D 10549292 (Pubitemid 29531140)
    • (1999) Molecular Cell , vol.4 , Issue.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3    Bradwin, G.4    Moore, K.5    Milstone, D.S.6    Spiegelman, B.M.7    Mortensen, R.M.8
  • 28
    • 0034214246 scopus 로고    scopus 로고
    • Transcriptional regulation of adipogenesis
    • 1:CAS:528:DC%2BD3cXjvFOgsb8%3D 10837022
    • E. D. Rosen C. J. Walkey P. Puigserver B. M. Spiegelman 2000 Transcriptional regulation of adipogenesis Genes Dev. 14 1293 1307 1:CAS:528:DC%2BD3cXjvFOgsb8%3D 10837022
    • (2000) Genes Dev. , vol.14 , pp. 1293-1307
    • Rosen, E.D.1    Walkey, C.J.2    Puigserver, P.3    Spiegelman, B.M.4
  • 30
    • 0017037481 scopus 로고
    • 2(α) and 1 methyl 3 isobutyl xanthine
    • DOI 10.1073/pnas.73.12.4516
    • T. R. Russell R. Ho 1976 Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine Proc. Natl. Acad. Sci. U. S. A. 73 4516 4520 10.1073/pnas.73.12.4516 1:CAS:528:DyaE2sXmsF2iuw%3D%3D 188043 (Pubitemid 8013931)
    • (1976) Proceedings of the National Academy of Sciences of the United States of America , vol.73 , Issue.12 , pp. 4516-4520
    • Russell, T.R.1    Ho, R.J.2
  • 33
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARgamma
    • 10.1146/annurev.biochem.77.061307.091829 1:CAS:528:DC%2BD1cXos1ekur4%3D 18518822
    • P. Tontonoz B. M. Spiegelman 2008 Fat and beyond: the diverse biology of PPARgamma Annu. Rev. Biochem. 77 289 312 10.1146/annurev.biochem.77.061307. 091829 1:CAS:528:DC%2BD1cXos1ekur4%3D 18518822
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 34
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • DOI 10.1079/BJN20041213
    • P. Trayhurn I. S. Wood 2004 Adipokines: inflammation and the pleiotropic role of white adipose tissue Br. J. Nutr. 92 347 355 10.1079/BJN20041213 1:CAS:528:DC%2BD2cXosV2gtL0%3D 15469638 (Pubitemid 40277057)
    • (2004) British Journal of Nutrition , vol.92 , Issue.3 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 35
    • 33845683903 scopus 로고    scopus 로고
    • The vascular biology of peroxisome proliferator-activated receptors: Modulation of atherosclerosis
    • 16498507
    • S. Verma P. E. Szmitko 2006 The vascular biology of peroxisome proliferator-activated receptors: modulation of atherosclerosis Can. J. Cardiol. 22 Suppl.B 12B 17B 16498507
    • (2006) Can. J. Cardiol. , vol.22 , Issue.SUPPL. B
    • Verma, S.1    Szmitko, P.E.2
  • 36
    • 0028792423 scopus 로고
    • Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist
    • 10.1055/s-2006-959361 1:CAS:528:DyaK28XotVGhsA%3D%3D 8824945
    • H. O. Yang Y. H. Kang D. Y. Suh Y. C. Kim B. H. Han 1995 Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist Planta Med. 61 519 522 10.1055/s-2006-959361 1:CAS:528: DyaK28XotVGhsA%3D%3D 8824945
    • (1995) Planta Med. , vol.61 , pp. 519-522
    • Yang, H.O.1    Kang, Y.H.2    Suh, D.Y.3    Kim, Y.C.4    Han, B.H.5
  • 37
    • 0028843523 scopus 로고
    • Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis
    • 10.1055/s-2006-957995 1:CAS:528:DyaK2MXktVSgtLg%3D 7700989
    • H. O. Yang D. Y. Suh B. H. Han 1995 Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis Planta Med. 61 37 40 10.1055/s-2006-957995 1:CAS:528:DyaK2MXktVSgtLg%3D 7700989
    • (1995) Planta Med. , vol.61 , pp. 37-40
    • Yang, H.O.1    Suh, D.Y.2    Han, B.H.3
  • 38
    • 2942532733 scopus 로고    scopus 로고
    • Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver
    • DOI 10.1016/j.jep.2004.03.037, PII S037887410400162X
    • J. X. Zhu Y. Wang L. D. Kong C. Yang X. Zhang 2004 Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver J. Ethnopharmacol. 93 133 140 10.1016/j.jep.2004.03.037 1:CAS:528:DC%2BD2cXks1WrsL8%3D 15182918 (Pubitemid 38739283)
    • (2004) Journal of Ethnopharmacology , vol.93 , Issue.1 , pp. 133-140
    • Zhu, J.X.1    Wang, Y.2    Kong, L.D.3    Yang, C.4    Zhang, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.