Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4228-4232

  Shults, E E ^a   Velder, J ^b   Schmalz, H G ^b   Chernov, S V ^a   Rubalova, T V ^a   Gatilov, Y V ^a   Henze, G ^c   Tolstikov, G A ^a   Prokop, A ^c  

^a N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b UNIVERSITY OF COLOGNE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Apoptosis; Labdane diterpenes; Leukemia; Natural products; Synthesis

Indexed keywords

ANTILEUKEMIC AGENT; DITERPENE; DNA FRAGMENT; PINUSOLIDE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BURKITT LYMPHOMA; CHILD; CONCENTRATION (PARAMETERS); DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; EX VIVO STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOBLAST; MITOCHONDRION; PINE; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL LINE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DITERPENES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOCYTIC, ACUTE; MITOCHONDRIA; MODELS, CHEMICAL; MODELS, MOLECULAR; NAPHTHALENES;

PINUS SIBIRICA;

EID: 33745727152     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.077     Document Type: Article

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