DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Wang, Ying ^a   Gao, Wenli ^a   Svitkin, Yuri V ^b   Chen, Annie Pei Chun ^a   Cheng, Yung Chi ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CYCLIN D1; CYCLOHEXIMIDE; DCB 3503; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; NSC 716802; PROTEASOME INHIBITOR; PROTEIN P21; PROTEIN P53; RAPAMYCIN; SURVIVIN; THYMIDINE; UNCLASSIFIED DRUG; URIDINE; ALKALOID; AMINO ACID; INDOLIZINE DERIVATIVE; PHENANTHRENE DERIVATIVE; TYLOPHORINE;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; HALF LIFE TIME; HELA CELL; IN VITRO STUDY; ISOTOPE LABELING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; CHEMISTRY; DRUG EFFECT; HUMAN; METABOLISM; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; POLYSOME; PROTEIN SYNTHESIS; TUMOR CELL LINE; WESTERN BLOTTING;

MUS MUSCULUS;

ALKALOIDS; AMINO ACIDS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE, TUMOR; HUMANS; INDOLIZINES; PHENANTHRENES; POLYMERASE CHAIN REACTION; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; THYMIDINE;

EID: 77955403531     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011607     Document Type: Article

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