β-catenin (CTNNB1) gene amplification: A new mechanism of protein overexpression in cancer

Genes Chromosomes and Cancer

Volumn 42, Issue 3, 2005, Pages 238-246

  Suriano, Gianpaolo ^a,b   Vrcelj, Nikoleta ^a   Senz, Janine ^a   Ferreira, Paulo ^b   Masoudi, Hamid ^a   Cox, Kelley ^a   Nabais, Sergio ^b,d   Lopes, Carlos ^c   Machado, José Carlos ^b,d   Seruca, Raquel ^b,d   Carneiro, Fatima ^b,d   Huntsman, David G ^a,e  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF PORTO   (Portugal)

^c PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^d HOSPITAL DE SÃO JOÃO   (Portugal)

^e BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; GENE PRODUCT;

ARTICLE; AXIN GENE; CANCER; CANCER CELL CULTURE; CELL NUCLEUS; CELL STRAIN KATO III; CELL STRAIN ST2957; CLINICAL ARTICLE; CTNNB1 GENE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE ACTIVATION; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR TRANSPORT; MULTIPLEX LIGATION PROBE AMPLIFICATION; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; QUANTITATIVE REAL TIME POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

BETA CATENIN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CELL NUCLEUS; CYCLIN D1; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; EXONS; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTESTINAL NEOPLASMS; MUTATION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 19944433965     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.20135     Document Type: Article

References (45)

1. Ai Z, Fischer A, Spray DC, Brown AM, Fishman GI. 2000. Wnt-1 regulation of connexin43 in cardiac myocytes. J Clin Invest 105:161-171.
2. Bienz M, Clevers M. 2000. Linking colorectal cancer to Wnt signaling. Cell 103:311-320.
3. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Carneiro F. 1997. Classification of gastric carcinomas. Curr Diag Pathol 4:51-59.
5. Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C, Groden J, Lowy AM. 2002. beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 62:3503-3506.
6. Clevers H. 2004. Wnt breakers in colon cancer. Cancer Cell 5:5-6.
7. Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A. 2002. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest 109:987-991.
8. Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, Matrisian LM. 1999. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 18:2883-2891.
9. Duval A, Gayet J, Zhou XP, Iacopetta B, Thomas G, Hamelin R. 1999. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. Cancer Res 59:4213-4215.
10. Ebert MP, Fei G, Kahmann S, Muller O, Yu J, Sung JJ, Malfertheiner P. 2002. Increased beta-catenin mRNA levels and mutational alterations of the APC and beta-catenin gene are present in intestinal-type gastric cancer. Carcinogenesis 23:87-91.
11. Ebert MP, Yu J, Hoffmann I, Rocco A, Rocken C, Kahmann S, Muller O, Korc M, Sung JJ, Malfertheiner P. 2003. Loss of beta-catenin expression in metastatic gastric cancer. J Clin Oncol 21:1708-1714.
12. El-Rifai W, Frierson HF, Harper JC, Powell SM, Knuutila S. 2001. Expression profiling of gastric adenocarcinoma using cDNA array. Int J Cancer. 92:832-838.
13. Garnis C, Baldwin C, Zhang L, Rosin MP, Lam WL. 2003. Use of complete coverage array comparative genomic hybridization to define copy number alterations on chromosome 3p in oral squamous cell carcinomas. Cancer Res 63:8582-8585.
14. Giles RH, van Es JH, Clevers H. 2003. Caught up in a Wnt storm: Wnt signaling in cancer. Biochem Biophys Acta 1653:1-24.
15. Gradl D, Kuhl M, Wedlich D. 1999. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 19:5576-5587.
16. Hara T, Ooi A, Kobayashi M, Mai M, Yanagiharu K, Nakanishi I. 1998. Amplification of c-myc, K-sam, and c-met in gastric cancers: detection by fluorescence in situ hybridization. Lab Invest 78:1143-1153.
17. Haydon RC, Deyrup A, Ishikawa A, Heck R, Jiang W, Zhou L, Feng T, King D, Cheng H, Breyer B, Peabody T, Simon MA, Montag AG, He TC. 2002. Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer 102:338-342.
18. He TC, Sparks AB, Rago C, Hermeking H, Zawel LT, da Costa L, Morin PJ, Vogelstein B, Kinzler KW. 1998. Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512.
19. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schmuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. 2003. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 115:523-535.
20. Kim HS, Hong EK, Park SY, Kim WH, Lee HS. 2003. Expression of beta-catenin and E-cadherin in the adenoma-carcinoma sequence of the stomach. Anticancer Res 23:2863-2868.
21. Koh TJ, Bulitta CJ, Fleming JV, Dockray GJ, Varro A, Wang TC. 2000. Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest 106:533-539.
22. Lauren P. 1962. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31-49.
23. Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN. 2000. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat Genet 26:146-147.
24. Mirabelli-Primdahl L, Gryfe R, Kim H, Millar A, Luceri C, Dale D, Holowaty E, Bapat B, Gallinger S, Redston M. 1999. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. Cancer Res 59:3346-3351.
25. Nabais S, Machado JC, Lopes C, Seruca R, Carneiro F, Sobrinho-Simoes M. 2003. Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis. Int J Surg Pathol 11:1-9.
26. Nakatsuru S, Yanagisawa A, Ichii S, Tahara E, Kato Y, Nakamura Y, Horii A. 1992. Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. Hum Mol Genet 1:559-563.
27. Offerhaus GJ, Giardiello FM, Krush AJ, Booker SV, Tersmette AC, Kelley NC, Hamilton SR. 1992. The risk of upper gastrointestinal cancer in familial adenomatous polyposis. Gastroenterology 102:1980-1992.
28. Oliveira C, Seruca R, Seixas M, Sobrinho-Simoes M. 1998. The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes. Am J Pathol 153:1211-1219.
29. Omholt K, Platz A, Ringborg U, Hansson J. 2001. Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer 92:839-842.
30. Pinto M, Oliveira C, Cirnes L, Machado JC, Ramires M, Nogueira A, Carneiro F, Seruca R. 2003. Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas. J Pathol 200:32-38.
31. Polakis P. 1997. The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1332:127-147.
32. Polakis P. 2000. Wnt signaling and cancer. Genes Dev 14:1837-1851.
33. Prange W, Breuhahn K, Fischer F, Zilkens C, Pietsch T, Petmecky K, Eilers R, Dienes HP, Schirmacher P. 2003. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol 201:250-259.
34. Rosin-Arbesfeld R, Cliffe A, Brabletz T, Bienz M. 2003. EMBO J 22:1101-1113.
35. Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y. 2000. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 24:245-250.
36. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A. 1999. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway Proc Natl Acad Sci USA 96:5522-5527.
37. Suriano G, Oliveira MJ, Huntsman D, Mateus AR, Ferreira P, Casares F, Oliveira C, Carneiro F, Machado JC, Mareel M, Seruca R. 2003. E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells. Hum Mol Genet 12:3007-3016.
38. Taipale J, Beachy PA. 2001. The Hedgehog and Wnt signalling pathways in cancer. Nature 411:349-354.
39. Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W. 2002. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 21:4863-4871.
40. Tsukamoto T, Yamamoto M, Ogasawara N, Ushijima T, Nomoto T, Fujita H, Matsushima T, Nozaki K, Cao X, Tatematsu M. 2003. beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer Sci 94:1046-1051.
41. Webster MT, Rozycka M, Sara E, Davis E, Smalley M, Young N, Dale TC, Wooster R. 2000. Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes Cancer 28:443-453.
42. Woo DK, Kim HS, Lee HS, Rang YH, Yang HK, Kim WH. 2001. Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines. Int J Cancer 95:108-113.
43. Yamada T, Takaoka AS, Naishiro Y, Hayashi R, Maruyama K, Maesawa C, Ochiai A, Hirohashi S. 2000. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Res 60:4761-4766.
44. Yokozaki H. 2000. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol Int 50:767-777.
45. Yokozaki H, Yasui W, Tahara E. 2001. Genetic and epigenetic changes in stomach cancer. Int Rev Cytol 204:49-95.