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Volumn 184, Issue C, 2010, Pages 35-51

Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease

Author keywords

Animal models; Cognitive impairment; Locomotor activity; Motor impairment; Motor learning; Nigrostriatal lesions; Psychiatric impairment; Reinforcement; Rotation; Sensorimotor tests

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; DJ 1 PROTEIN; LEUCINE RICH REPEAT KINASE 2; LEVODOPA; NEUROTOXIN; PARAQUAT; PARKIN; PROTEIN PINK1; PROTEIN SERINE THREONINE KINASE; ROTENONE; UNCLASSIFIED DRUG;

EID: 77955383138     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(10)84003-8     Document Type: Chapter
Times cited : (37)

References (110)
  • 1
    • 0003155081 scopus 로고
    • Skilled paw reaching in rats: The staircase test
    • Abrous D.N., Dunnett S.B. Skilled paw reaching in rats: The staircase test. Neuroscience Protection 1994, 3:1-11.
    • (1994) Neuroscience Protection , vol.3 , pp. 1-11
    • Abrous, D.N.1    Dunnett, S.B.2
  • 2
    • 0027452902 scopus 로고
    • Dopamine-rich grafts in the neostriatum and/or nucleus accumbens: Effects on drug-induced behaviours and skilled paw-reaching
    • Abrous D.N., Shaltot A.R.A., Torres E.M., Dunnett S.B. Dopamine-rich grafts in the neostriatum and/or nucleus accumbens: Effects on drug-induced behaviours and skilled paw-reaching. Neuroscience 1993, 53:187-197.
    • (1993) Neuroscience , vol.53 , pp. 187-197
    • Abrous, D.N.1    Shaltot, A.R.A.2    Torres, E.M.3    Dunnett, S.B.4
  • 3
    • 0026448509 scopus 로고
    • Unilateral dopamine lesions in neonatal, weanling and adult rats: Comparison of rotation and reaching deficits
    • Abrous D.N., Wareham A.T., Torres E.M., Dunnett S.B. Unilateral dopamine lesions in neonatal, weanling and adult rats: Comparison of rotation and reaching deficits. Behavioural Brain Research 1992, 51:67-75.
    • (1992) Behavioural Brain Research , vol.51 , pp. 67-75
    • Abrous, D.N.1    Wareham, A.T.2    Torres, E.M.3    Dunnett, S.B.4
  • 4
    • 39449113020 scopus 로고    scopus 로고
    • Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice
    • Alvarez-Fischer D., Henze C., Strenzke C., Westrich J., Ferger B., Hoglinger G.U., et al. Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Experimental Neurology 2008, 210:182-193.
    • (2008) Experimental Neurology , vol.210 , pp. 182-193
    • Alvarez-Fischer, D.1    Henze, C.2    Strenzke, C.3    Westrich, J.4    Ferger, B.5    Hoglinger, G.U.6
  • 7
    • 27144542972 scopus 로고    scopus 로고
    • Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
    • Barnes T.D., Kubota Y., Hu D., Jin D.Z.Z., Graybiel A.M. Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories. Nature 2005, 437:1158-1161.
    • (2005) Nature , vol.437 , pp. 1158-1161
    • Barnes, T.D.1    Kubota, Y.2    Hu, D.3    Jin, D.Z.Z.4    Graybiel, A.M.5
  • 9
    • 13444304271 scopus 로고    scopus 로고
    • Lesion of the substantia nigra, pars compacta impairs delayed alternation in a Y-maze in rats
    • Braga R., Kouzmine I., Canteras N.S., Da Cunha C. Lesion of the substantia nigra, pars compacta impairs delayed alternation in a Y-maze in rats. Experimental Neurology 2005, 192:134-141.
    • (2005) Experimental Neurology , vol.192 , pp. 134-141
    • Braga, R.1    Kouzmine, I.2    Canteras, N.S.3    Da Cunha, C.4
  • 10
    • 48349148611 scopus 로고    scopus 로고
    • Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model
    • Branchi I., DAndrea I., Armida M., Cassano T., Pezzola A., Potenza R.L., et al. Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model. Journal of Neuroscience Research 2008, 86:2050-2061.
    • (2008) Journal of Neuroscience Research , vol.86 , pp. 2050-2061
    • Branchi, I.1    DAndrea, I.2    Armida, M.3    Cassano, T.4    Pezzola, A.5    Potenza, R.L.6
  • 12
    • 0026033182 scopus 로고
    • Simple and choice reaction time performance following unilateral striatal dopamine depletion in the rat. Impaired motor readiness but preserved response preparation
    • Brown V.J., Robbins T.W. Simple and choice reaction time performance following unilateral striatal dopamine depletion in the rat. Impaired motor readiness but preserved response preparation. Brain 1991, 114:513-525.
    • (1991) Brain , vol.114 , pp. 513-525
    • Brown, V.J.1    Robbins, T.W.2
  • 14
    • 0021995997 scopus 로고
    • Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention
    • Carli M., Evenden J.L., Robbins T.W. Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention. Nature 1985, 313:679-682.
    • (1985) Nature , vol.313 , pp. 679-682
    • Carli, M.1    Evenden, J.L.2    Robbins, T.W.3
  • 15
    • 0020502372 scopus 로고
    • Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal
    • Carli M., Robbins T.W., Evenden J.L., Everitt B.J. Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioural Brain Research 1983, 9:361-380.
    • (1983) Behavioural Brain Research , vol.9 , pp. 361-380
    • Carli, M.1    Robbins, T.W.2    Evenden, J.L.3    Everitt, B.J.4
  • 16
    • 0000015266 scopus 로고
    • The occurrence, distribution and physiological role of catecholamines in the nervous system
    • Carlsson A. The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmacological Reviews 1959, 11:490-493.
    • (1959) Pharmacological Reviews , vol.11 , pp. 490-493
    • Carlsson, A.1
  • 17
    • 0000428532 scopus 로고
    • 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists
    • Carlsson A., Lindqvist M., Magnusson T. 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 1957, 180:1200.
    • (1957) Nature , vol.180 , pp. 1200
    • Carlsson, A.1    Lindqvist, M.2    Magnusson, T.3
  • 19
    • 84882327552 scopus 로고    scopus 로고
    • Utility of 6-hydroxydopamine lesioned rats in the preclinical screening of novel treatments for Parkinson disease
    • Elsevier, Amsterdam, M. LeDoux (Ed.)
    • Cenci M.A., Lundblad M. Utility of 6-hydroxydopamine lesioned rats in the preclinical screening of novel treatments for Parkinson disease. Animal models of movement disorders 2005, 193-209. Elsevier, Amsterdam. M. LeDoux (Ed.).
    • (2005) Animal models of movement disorders , pp. 193-209
    • Cenci, M.A.1    Lundblad, M.2
  • 20
    • 39549094242 scopus 로고    scopus 로고
    • Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function
    • Chandran J.S., Lin X., Zapata A., Hoeke A., Shimoji M., Moore S.O., et al. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiology of Disease 2008, 29:505-514.
    • (2008) Neurobiology of Disease , vol.29 , pp. 505-514
    • Chandran, J.S.1    Lin, X.2    Zapata, A.3    Hoeke, A.4    Shimoji, M.5    Moore, S.O.6
  • 21
    • 32544432029 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Diagnosis and management
    • Chaudhuri K.R., Healy D.G., Schapira A.H. Non-motor symptoms of Parkinson's disease: Diagnosis and management. Lancet Neurology 2006, 5:235-245.
    • (2006) Lancet Neurology , vol.5 , pp. 235-245
    • Chaudhuri, K.R.1    Healy, D.G.2    Schapira, A.H.3
  • 22
    • 64349083816 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
    • Chaudhuri K.R., Schapira A.H. Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment. Lancet Neurology 2009, 8:464-474.
    • (2009) Lancet Neurology , vol.8 , pp. 464-474
    • Chaudhuri, K.R.1    Schapira, A.H.2
  • 23
    • 0017651245 scopus 로고
    • Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity
    • Creese I., Burt D.R., Snyder S.H. Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Science 1977, 197:596-598.
    • (1977) Science , vol.197 , pp. 596-598
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 24
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons
    • Dahlström A., Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiologica Scandinavica Supplementum 1964, 232:1-55.
    • (1964) Acta Physiologica Scandinavica Supplementum , vol.232 , pp. 1-55
    • Dahlström, A.1    Fuxe, K.2
  • 25
    • 0014365843 scopus 로고
    • Effects of prefrontal and caudate lesions on delayed response in cats
    • Divac I. Effects of prefrontal and caudate lesions on delayed response in cats. Acta Neurobiologiae Experimentalis 1968, 28:149-167.
    • (1968) Acta Neurobiologiae Experimentalis , vol.28 , pp. 149-167
    • Divac, I.1
  • 27
    • 0345227298 scopus 로고    scopus 로고
    • Motor training affects recovery of function after striatal lesions and grafts
    • Döbrössy M.D., Dunnett S.B. Motor training affects recovery of function after striatal lesions and grafts. Experimental Neurology 2003, 184:184-194.
    • (2003) Experimental Neurology , vol.184 , pp. 184-194
    • Döbrössy, M.D.1    Dunnett, S.B.2
  • 28
    • 8144229502 scopus 로고    scopus 로고
    • Deficits in a lateralised associative learning task in dopamine-depleted rats, with selective recovery by dopamine-rich transplants
    • Dowd E., Dunnett S.B. Deficits in a lateralised associative learning task in dopamine-depleted rats, with selective recovery by dopamine-rich transplants. European Journal of Neuroscience 2004, 20:1953-1959.
    • (2004) European Journal of Neuroscience , vol.20 , pp. 1953-1959
    • Dowd, E.1    Dunnett, S.B.2
  • 29
    • 34247177105 scopus 로고    scopus 로고
    • Movement without dopamine: Striatal dopamine is required to maintain but not to perform learned actions
    • Dowd E., Dunnett S.B. Movement without dopamine: Striatal dopamine is required to maintain but not to perform learned actions. Biochemical Society Transactions 2007, 35:428-432.
    • (2007) Biochemical Society Transactions , vol.35 , pp. 428-432
    • Dowd, E.1    Dunnett, S.B.2
  • 30
    • 28744446884 scopus 로고    scopus 로고
    • Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model
    • Dowd E., Monville C., Torres E.M., Azzouz M., Wong L.F., Mazarakis N.D., et al. Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. European Journal of Neuroscience 2005, 22:2587-2595.
    • (2005) European Journal of Neuroscience , vol.22 , pp. 2587-2595
    • Dowd, E.1    Monville, C.2    Torres, E.M.3    Azzouz, M.4    Wong, L.F.5    Mazarakis, N.D.6
  • 32
    • 0028872929 scopus 로고
    • Functional repair of striatal systems by neural transplants: Evidence for circuit reconstruction
    • Dunnett S.B. Functional repair of striatal systems by neural transplants: Evidence for circuit reconstruction. Behavioural Brain Research 1995, 66:133-142.
    • (1995) Behavioural Brain Research , vol.66 , pp. 133-142
    • Dunnett, S.B.1
  • 33
    • 77957235600 scopus 로고    scopus 로고
    • Motor functions of the nigrostriatal dopamine system: Studies of lesions and behaviour
    • Elsevier, Amsterdam, Dopamine, S.B. Dunnett, M. Bentivoglio, A. Björklund, T. Hökfelt (Eds.)
    • Dunnett S.B. Motor functions of the nigrostriatal dopamine system: Studies of lesions and behaviour. Handbook of chemical neuroanatomy. 2005, Vol. 21:235-299. Elsevier, Amsterdam, Dopamine. S.B. Dunnett, M. Bentivoglio, A. Björklund, T. Hökfelt (Eds.).
    • (2005) Handbook of chemical neuroanatomy. , vol.21 , pp. 235-299
    • Dunnett, S.B.1
  • 34
    • 0023919424 scopus 로고
    • Striatal grafts in rats with unilateral neostriatal lesions. III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching
    • Dunnett S.B., Isacson O., Sirinathsinghji D.J.S., Clarke D.J., Björklund A. Striatal grafts in rats with unilateral neostriatal lesions. III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience 1988, 24:813-820.
    • (1988) Neuroscience , vol.24 , pp. 813-820
    • Dunnett, S.B.1    Isacson, O.2    Sirinathsinghji, D.J.S.3    Clarke, D.J.4    Björklund, A.5
  • 35
    • 0019384586 scopus 로고
    • Learning impairments following selective kainic acid-induced lesions within the neostriatum of rats
    • Dunnett S.B., Iversen S.D. Learning impairments following selective kainic acid-induced lesions within the neostriatum of rats. Behavioural Brain Research 1981, 2:189-209.
    • (1981) Behavioural Brain Research , vol.2 , pp. 189-209
    • Dunnett, S.B.1    Iversen, S.D.2
  • 36
    • 0020363241 scopus 로고
    • Neurotoxic lesions of ventrolateral but not anteromedial neostriatum in rats impair differential reinforcement of low rates (DRL) performance
    • Dunnett S.B., Iversen S.D. Neurotoxic lesions of ventrolateral but not anteromedial neostriatum in rats impair differential reinforcement of low rates (DRL) performance. Behavioural Brain Research 1982, 6:213-226.
    • (1982) Behavioural Brain Research , vol.6 , pp. 213-226
    • Dunnett, S.B.1    Iversen, S.D.2
  • 37
    • 0027082006 scopus 로고
    • The functional role of the mesotelencephalic dopamine systems
    • Dunnett S.B., Robbins T.W. The functional role of the mesotelencephalic dopamine systems. Biological Reviews 1992, 67:491-518.
    • (1992) Biological Reviews , vol.67 , pp. 491-518
    • Dunnett, S.B.1    Robbins, T.W.2
  • 38
    • 0023191549 scopus 로고
    • Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions
    • Dunnett S.B., Whishaw I.Q., Rogers D.C., Jones G.H. Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions. Brain Research 1987, 415:63-78.
    • (1987) Brain Research , vol.415 , pp. 63-78
    • Dunnett, S.B.1    Whishaw, I.Q.2    Rogers, D.C.3    Jones, G.H.4
  • 39
    • 33947127695 scopus 로고    scopus 로고
    • Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
    • Eslamboli A., RomeroRamos M., Burger C., Björklund T., Muzyczka N., Mandel R.J., et al. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain 2007, 130:799-815.
    • (2007) Brain , vol.130 , pp. 799-815
    • Eslamboli, A.1    RomeroRamos, M.2    Burger, C.3    Björklund, T.4    Muzyczka, N.5    Mandel, R.J.6
  • 40
    • 15244346900 scopus 로고    scopus 로고
    • Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation
    • Haberland U., Conde F., El Massioui N. Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation. Journal of Neuroscience 2005, 25:2771-2780.
    • (2005) Journal of Neuroscience , vol.25 , pp. 2771-2780
    • Haberland, U.1    Conde, F.2    El Massioui, N.3
  • 41
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 42
    • 35748980554 scopus 로고    scopus 로고
    • Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test
    • Fletcher P.J., Tampakeras M., Sinyard J., Higgins G.A. Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. Psychopharmacology (Berlin) 2007, 195:223-234.
    • (2007) Psychopharmacology (Berlin) , vol.195 , pp. 223-234
    • Fletcher, P.J.1    Tampakeras, M.2    Sinyard, J.3    Higgins, G.A.4
  • 43
    • 0029980394 scopus 로고    scopus 로고
    • Memory, action and the corpus striatum-current developments in the memory-habit distinction
    • Gaffan D. Memory, action and the corpus striatum-current developments in the memory-habit distinction. Seminars in Neuroscience 1996, 8:33-38.
    • (1996) Seminars in Neuroscience , vol.8 , pp. 33-38
    • Gaffan, D.1
  • 46
    • 0018894295 scopus 로고
    • Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effects of amphetamine, apomorphine, & DOPA
    • Hefti F., Melamed E., Sahakian B.J., Wurtman R.J. Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effects of amphetamine, apomorphine, & DOPA. Pharmacology Biochemistry and Behavior 1980, 12:185-188.
    • (1980) Pharmacology Biochemistry and Behavior , vol.12 , pp. 185-188
    • Hefti, F.1    Melamed, E.2    Sahakian, B.J.3    Wurtman, R.J.4
  • 47
    • 55849122639 scopus 로고    scopus 로고
    • Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
    • Henchcliffe C., Beal M.F. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Clinical Practice Neurology 2008, 4:600-609.
    • (2008) Nature Clinical Practice Neurology , vol.4 , pp. 600-609
    • Henchcliffe, C.1    Beal, M.F.2
  • 48
    • 10444252650 scopus 로고    scopus 로고
    • Food-reinforced operant behavior in dopamine transporter knockout mice: Enhanced resistance to extinction
    • Hironaka N., Ikeda K., Sora I., Uhl G.R., Niki H. Food-reinforced operant behavior in dopamine transporter knockout mice: Enhanced resistance to extinction. Annals of the New York Academy of Sciences 2004, 1025:140-145.
    • (2004) Annals of the New York Academy of Sciences , vol.1025 , pp. 140-145
    • Hironaka, N.1    Ikeda, K.2    Sora, I.3    Uhl, G.R.4    Niki, H.5
  • 49
    • 0032867020 scopus 로고    scopus 로고
    • Visuospatial attentional functioning in mice: Interactions between cholinergic manipulations and genotype
    • Humby T., Laird F.M., Davis W., Wilkinson L.S. Visuospatial attentional functioning in mice: Interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 1999, 11:2813-2823.
    • (1999) European Journal of Neuroscience , vol.11 , pp. 2813-2823
    • Humby, T.1    Laird, F.M.2    Davis, W.3    Wilkinson, L.S.4
  • 50
    • 70349405968 scopus 로고    scopus 로고
    • Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit
    • Humphries M.D., Wood R., Gurney K. Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit. Neural Network 2009, 22:1174-1188.
    • (2009) Neural Network , vol.22 , pp. 1174-1188
    • Humphries, M.D.1    Wood, R.2    Gurney, K.3
  • 52
    • 0014728372 scopus 로고
    • The cortico-striate projection in the monkey
    • Kemp J.M., Powell T.P.S. The cortico-striate projection in the monkey. Brain 1970, 93:525-546.
    • (1970) Brain , vol.93 , pp. 525-546
    • Kemp, J.M.1    Powell, T.P.S.2
  • 53
    • 0032143368 scopus 로고    scopus 로고
    • Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    • Kirik D., Rosenblad C., Björklund A. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Experimental Neurology 1998, 152:259-277.
    • (1998) Experimental Neurology , vol.152 , pp. 259-277
    • Kirik, D.1    Rosenblad, C.2    Björklund, A.3
  • 54
    • 0036550101 scopus 로고    scopus 로고
    • Parkinson-like neurodegeneration induced by targeted overexpression of a-synuclein in the nigrostriatal system
    • Kirik D., Rosenblad C., Burger C., Lundberg C., Johansen T.E., Muzyczka N., et al. Parkinson-like neurodegeneration induced by targeted overexpression of a-synuclein in the nigrostriatal system. Journal of Neuroscience 2002, 22:2780-2791.
    • (2002) Journal of Neuroscience , vol.22 , pp. 2780-2791
    • Kirik, D.1    Rosenblad, C.2    Burger, C.3    Lundberg, C.4    Johansen, T.E.5    Muzyczka, N.6
  • 55
    • 0016640957 scopus 로고
    • Double dissociation of spatial impairments and perseveration following selective prefrontal lesions in rats
    • Kolb B., Sutherland R.J., Singh R.K. Double dissociation of spatial impairments and perseveration following selective prefrontal lesions in rats. Journal of Comparative and Physiological Psychology 1975, 88:806-815.
    • (1975) Journal of Comparative and Physiological Psychology , vol.88 , pp. 806-815
    • Kolb, B.1    Sutherland, R.J.2    Singh, R.K.3
  • 57
    • 67649813448 scopus 로고    scopus 로고
    • Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    • Li Y., Liu W., Oo T.F., Wang L., Tang Y., Jackson-Lewis V., et al. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience 2009, 12:826-828.
    • (2009) Nature Neuroscience , vol.12 , pp. 826-828
    • Li, Y.1    Liu, W.2    Oo, T.F.3    Wang, L.4    Tang, Y.5    Jackson-Lewis, V.6
  • 58
    • 0002303119 scopus 로고
    • The action of central nervous system stimulant drugs: A general theory concerning amphetamine effects
    • Spectum, New York, W. Essman, L. Valzelli (Eds.)
    • Lyon M., Robbins T.W. The action of central nervous system stimulant drugs: A general theory concerning amphetamine effects. Current developments in psychopharmacology 1975, 79-163. Spectum, New York. W. Essman, L. Valzelli (Eds.).
    • (1975) Current developments in psychopharmacology , pp. 79-163
    • Lyon, M.1    Robbins, T.W.2
  • 59
    • 34447621054 scopus 로고    scopus 로고
    • Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter
    • Manning-Bog A.B., Caudle W.M., Perez X.A., Reaney S.H., Paletzki R., Isla M.Z., et al. Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter. Neurobiology of Disease 2007, 27:141-150.
    • (2007) Neurobiology of Disease , vol.27 , pp. 141-150
    • Manning-Bog, A.B.1    Caudle, W.M.2    Perez, X.A.3    Reaney, S.H.4    Paletzki, R.5    Isla, M.Z.6
  • 60
    • 0020029213 scopus 로고
    • The mysterious motor function of the basal ganglia
    • Marsden C.D. The mysterious motor function of the basal ganglia. Neurology 1992, 32:514-539.
    • (1992) Neurology , vol.32 , pp. 514-539
    • Marsden, C.D.1
  • 62
    • 0015244725 scopus 로고
    • Sensory neglect produced by lateral hypothalamic damage
    • Marshall J.F., Turner B.H., Teitelbaum P. Sensory neglect produced by lateral hypothalamic damage. Science 1971, 174:523-525.
    • (1971) Science , vol.174 , pp. 523-525
    • Marshall, J.F.1    Turner, B.H.2    Teitelbaum, P.3
  • 63
    • 30644471051 scopus 로고    scopus 로고
    • Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
    • Martin L.J., Pan Y., Price A.C., Sterling W., Copeland N.G., Jenkins N.A., et al. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. Journal of Neuroscience 2006, 26:41-50.
    • (2006) Journal of Neuroscience , vol.26 , pp. 41-50
    • Martin, L.J.1    Pan, Y.2    Price, A.C.3    Sterling, W.4    Copeland, N.G.5    Jenkins, N.A.6
  • 64
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in a-synuclein mice: Implications for neurodegenerative disorders
    • Masliah E., Rockenstein E.M., Veinbergs I., Mallory M., Hashimoto M., Takeda A., et al. Dopaminergic loss and inclusion body formation in a-synuclein mice: Implications for neurodegenerative disorders. Science 2000, 287:1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.M.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6
  • 65
    • 0024336026 scopus 로고
    • The organisation of the projection from the cerebral cortex to the striatum in the rat
    • McGeorge A.J., Faull R.L.M. The organisation of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 1989, 29:503-537.
    • (1989) Neuroscience , vol.29 , pp. 503-537
    • McGeorge, A.J.1    Faull, R.L.M.2
  • 66
    • 0028036660 scopus 로고
    • Skilled reaching deficits in unilateral dopamine-depleted rats: Impairments in movement and posture and compensatory adjustments
    • Miklyaeva E.I., Castañeda E., Whishaw I.Q. Skilled reaching deficits in unilateral dopamine-depleted rats: Impairments in movement and posture and compensatory adjustments. Journal of Neuroscience 1994, 14:7148-7158.
    • (1994) Journal of Neuroscience , vol.14 , pp. 7148-7158
    • Miklyaeva, E.I.1    Castañeda, E.2    Whishaw, I.Q.3
  • 67
    • 0003010468 scopus 로고
    • Memories and habits: Two neural systems
    • Guilford Press, New York, G. Lynch, J.L. McGaugh, N.M. Weinberger (Eds.)
    • Mishkin M., Malamut B., Bachevalier J. Memories and habits: Two neural systems. Neurobiology of learning and memory 1984, 65-77. Guilford Press, New York. G. Lynch, J.L. McGaugh, N.M. Weinberger (Eds.).
    • (1984) Neurobiology of learning and memory , pp. 65-77
    • Mishkin, M.1    Malamut, B.2    Bachevalier, J.3
  • 68
    • 0025108166 scopus 로고
    • Effects of nigral and striatal grafts on skilled forelimb use in the rat
    • Montoya C.P., Astell S., Dunnett S.B. Effects of nigral and striatal grafts on skilled forelimb use in the rat. Progress in Brain Research 1990, 82:459-466.
    • (1990) Progress in Brain Research , vol.82 , pp. 459-466
    • Montoya, C.P.1    Astell, S.2    Dunnett, S.B.3
  • 71
    • 0026724263 scopus 로고
    • Attentional functions of the forebrain cholinergic systems: Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task
    • Muir J.L., Dunnett S.B., Robbins T.W., Everitt B.J. Attentional functions of the forebrain cholinergic systems: Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Experimental Brain Research 1992, 89:611-622.
    • (1992) Experimental Brain Research , vol.89 , pp. 611-622
    • Muir, J.L.1    Dunnett, S.B.2    Robbins, T.W.3    Everitt, B.J.4
  • 72
    • 0041472606 scopus 로고    scopus 로고
    • Spatial learning in rats is impaired after degeneration of the nigrostriatal dopaminergic system
    • Mura A., Feldon J. Spatial learning in rats is impaired after degeneration of the nigrostriatal dopaminergic system. Movement Disorder 2003, 18:860-871.
    • (2003) Movement Disorder , vol.18 , pp. 860-871
    • Mura, A.1    Feldon, J.2
  • 73
    • 0029046161 scopus 로고
    • Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery
    • Nikkhah G., Cunningham M.G., McKay R., Björklund A. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery. Journal of Neuroscience 1995, 15:3562-3570.
    • (1995) Journal of Neuroscience , vol.15 , pp. 3562-3570
    • Nikkhah, G.1    Cunningham, M.G.2    McKay, R.3    Björklund, A.4
  • 74
    • 0001939741 scopus 로고
    • "Cognitive" functions of the neostriatum
    • Pergamon Press, Oxford, I. Divac, R.G.E. Öberg (Eds.)
    • Öberg R.G.E., Divac I. "Cognitive" functions of the neostriatum. The neostriatum 1979, 291-313. Pergamon Press, Oxford. I. Divac, R.G.E. Öberg (Eds.).
    • (1979) The neostriatum , pp. 291-313
    • Öberg, R.G.E.1    Divac, I.2
  • 75
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5    Dutra, A.6
  • 76
    • 0018903301 scopus 로고
    • Turning behaviour in animals
    • Pycock C.J. Turning behaviour in animals. Neuroscience 1980, 5:461-514.
    • (1980) Neuroscience , vol.5 , pp. 461-514
    • Pycock, C.J.1
  • 77
    • 0003109250 scopus 로고
    • A critique of methods available for the measurement of spontaneous motor activity
    • Plenum Press, New York, L.L. Iversen, S.D. Iversen, S.H. Snyder (Eds.)
    • Robbins T.W. A critique of methods available for the measurement of spontaneous motor activity. Handbook of psychopharmacology 1977, 37-82. Plenum Press, New York. L.L. Iversen, S.D. Iversen, S.H. Snyder (Eds.).
    • (1977) Handbook of psychopharmacology , pp. 37-82
    • Robbins, T.W.1
  • 79
  • 80
    • 0022415464 scopus 로고
    • The effect of peripheral noradrenaline depletion on responding on a schedule of differential reinforcement of low rates of response (DRL)
    • Salmon P., Stanford C., Gray J.A. The effect of peripheral noradrenaline depletion on responding on a schedule of differential reinforcement of low rates of response (DRL). Psychopharmacology (Berlin) 1985, 87:77-80.
    • (1985) Psychopharmacology (Berlin) , vol.87 , pp. 77-80
    • Salmon, P.1    Stanford, C.2    Gray, J.A.3
  • 81
    • 0000431473 scopus 로고    scopus 로고
    • Intervention strategies for degeneration of dopamine neurons in Parkinsonism: Optimising behavioral assessment of outcome
    • Humana Press, Totowa, NJ, D.F. Emerich, R.L. Dean, P.R. Sanberg (Eds.)
    • Schallert T., Tillerson J.L. Intervention strategies for degeneration of dopamine neurons in Parkinsonism: Optimising behavioral assessment of outcome. Central nervous system diseases: Innovative animal models from lab to clinic 2000, 131-151. Humana Press, Totowa, NJ. D.F. Emerich, R.L. Dean, P.R. Sanberg (Eds.).
    • (2000) Central nervous system diseases: Innovative animal models from lab to clinic , pp. 131-151
    • Schallert, T.1    Tillerson, J.L.2
  • 82
    • 0021000670 scopus 로고
    • Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism
    • Schmidt R.H., Björklund A., Stenevi U., Dunnett S.B., Gage F.H. Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism. Acta Physiologica Scandinavica Supplementum 1983, 522:19-28.
    • (1983) Acta Physiologica Scandinavica Supplementum , vol.522 , pp. 19-28
    • Schmidt, R.H.1    Björklund, A.2    Stenevi, U.3    Dunnett, S.B.4    Gage, F.H.5
  • 83
    • 0034576323 scopus 로고    scopus 로고
    • Multiple reward signals in the brain
    • Schultz W. Multiple reward signals in the brain. Nature Reviews Neuroscience 2000, 1:191-207.
    • (2000) Nature Reviews Neuroscience , vol.1 , pp. 191-207
    • Schultz, W.1
  • 84
    • 33845301143 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 193M mutant
    • Setsuie R., Wang Y.L., Mochizuki H., Osaka H., Hayakawa H., Ichihara N., et al. Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 193M mutant. Neurochemistry International 2007, 50:119-129.
    • (2007) Neurochemistry International , vol.50 , pp. 119-129
    • Setsuie, R.1    Wang, Y.L.2    Mochizuki, H.3    Osaka, H.4    Hayakawa, H.5    Ichihara, N.6
  • 85
    • 0019422901 scopus 로고
    • Dopaminergic A10 neurons and frontal system
    • Simon H. Dopaminergic A10 neurons and frontal system. Journal of Physiology (Paris) 1981, 77:81-95.
    • (1981) Journal of Physiology (Paris) , vol.77 , pp. 81-95
    • Simon, H.1
  • 86
    • 0028294093 scopus 로고
    • Effects of dopamine depletions in the medial prefrontal cortex on DRL performance and motor activity in the rat
    • Sokolowski J.D., Salamone J.D. Effects of dopamine depletions in the medial prefrontal cortex on DRL performance and motor activity in the rat. Brain Research 1994, 642:20-28.
    • (1994) Brain Research , vol.642 , pp. 20-28
    • Sokolowski, J.D.1    Salamone, J.D.2
  • 88
    • 72549103697 scopus 로고    scopus 로고
    • Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
    • Surmeier D.J., Plotkin J., Shen W. Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection. Current Opinion in Neurobiology. 2009, 10.1016/j.conb.2009.10.003.
    • (2009) Current Opinion in Neurobiology.
    • Surmeier, D.J.1    Plotkin, J.2    Shen, W.3
  • 90
    • 0022399747 scopus 로고
    • Alternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat
    • Taghzouti K., Louilot A., Herman J.P., Le Moal M., Simon H. Alternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat. Behavioral and Neural Biology 1985, 44:354-363.
    • (1985) Behavioral and Neural Biology , vol.44 , pp. 354-363
    • Taghzouti, K.1    Louilot, A.2    Herman, J.P.3    Le Moal, M.4    Simon, H.5
  • 92
    • 0032436807 scopus 로고    scopus 로고
    • Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues
    • Tzschentke T.M. Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues. Progress in Neurobiology 1998, 56:613-672.
    • (1998) Progress in Neurobiology , vol.56 , pp. 613-672
    • Tzschentke, T.M.1
  • 93
    • 0015182655 scopus 로고
    • Adipsia and aphagia after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system
    • Ungerstedt U. Adipsia and aphagia after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system. Acta Physiologica Scandinavica Supplementum 1971, 367:96-122.
    • (1971) Acta Physiologica Scandinavica Supplementum , vol.367 , pp. 96-122
    • Ungerstedt, U.1
  • 94
    • 0015184103 scopus 로고
    • Postsynaptic supersensitivity after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system
    • Ungerstedt U. Postsynaptic supersensitivity after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system. Acta Physiologica Scandinavica Supplementum 1971, 367:69-93.
    • (1971) Acta Physiologica Scandinavica Supplementum , vol.367 , pp. 69-93
    • Ungerstedt, U.1
  • 95
    • 0015164043 scopus 로고
    • Stereotaxic mapping of the monoamine pathways in the rat brain
    • Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiologica Scandinavica Supplementum 1971, 367:1-49.
    • (1971) Acta Physiologica Scandinavica Supplementum , vol.367 , pp. 1-49
    • Ungerstedt, U.1
  • 96
    • 0015176277 scopus 로고
    • Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour
    • Ungerstedt U. Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta Physiologica Scandinavica Supplementum 1971, 367:49-68.
    • (1971) Acta Physiologica Scandinavica Supplementum , vol.367 , pp. 49-68
    • Ungerstedt, U.1
  • 97
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system
    • Ungerstedt U., Arbuthnott G.W. Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Research 1970, 24:485-493.
    • (1970) Brain Research , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.W.2
  • 98
    • 0022358454 scopus 로고
    • Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues
    • Whishaw I.Q., Dunnett S.B. Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues. Behavioural Brain Research 1985, 18:11-29.
    • (1985) Behavioural Brain Research , vol.18 , pp. 11-29
    • Whishaw, I.Q.1    Dunnett, S.B.2
  • 99
    • 0023032147 scopus 로고
    • The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat
    • Whishaw I.Q., O'Connor W.T., Dunnett S.B. The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat. Brain 1986, 109:805-843.
    • (1986) Brain , vol.109 , pp. 805-843
    • Whishaw, I.Q.1    O'Connor, W.T.2    Dunnett, S.B.3
  • 100
    • 0025201875 scopus 로고
    • The structure of skilled forelimb reaching in the rat: A proximally driven movement with a single distal rotatory component
    • Whishaw I.Q., Pellis S.M. The structure of skilled forelimb reaching in the rat: A proximally driven movement with a single distal rotatory component. Behavioural Brain Research 1990, 41:49-59.
    • (1990) Behavioural Brain Research , vol.41 , pp. 49-59
    • Whishaw, I.Q.1    Pellis, S.M.2
  • 102
    • 33745760564 scopus 로고    scopus 로고
    • The role of the basal ganglia in habit formation
    • Yin H.H., Knowlton B.J. The role of the basal ganglia in habit formation. Nature Reviews Neuroscience 2006, 7:464-476.
    • (2006) Nature Reviews Neuroscience , vol.7 , pp. 464-476
    • Yin, H.H.1    Knowlton, B.J.2
  • 103
    • 1642580578 scopus 로고    scopus 로고
    • Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
    • Yin H.H., Knowlton B.J., Balleine B.W. Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. European Journal of Neuroscience 2004, 19:181-189.
    • (2004) European Journal of Neuroscience , vol.19 , pp. 181-189
    • Yin, H.H.1    Knowlton, B.J.2    Balleine, B.W.3
  • 104
    • 23244461369 scopus 로고    scopus 로고
    • Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning
    • Yin H.H., Knowlton B.J., Balleine B.W. Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning. European Journal of Neuroscience 2005, 22:505-512.
    • (2005) European Journal of Neuroscience , vol.22 , pp. 505-512
    • Yin, H.H.1    Knowlton, B.J.2    Balleine, B.W.3
  • 105
    • 28944442093 scopus 로고    scopus 로고
    • Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning
    • Yin H.H., Knowlton B.J., Balleine B.W. Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning. Behavioural Brain Research 2006, 166:189-196.
    • (2006) Behavioural Brain Research , vol.166 , pp. 189-196
    • Yin, H.H.1    Knowlton, B.J.2    Balleine, B.W.3
  • 108
  • 109
    • 0015528861 scopus 로고
    • Deficits in feeding behavior after intraventricular injection of 6-hydroxydopamine in rats
    • Zigmond M.J., Stricker E.M. Deficits in feeding behavior after intraventricular injection of 6-hydroxydopamine in rats. Science 1972, 177:1211-1214.
    • (1972) Science , vol.177 , pp. 1211-1214
    • Zigmond, M.J.1    Stricker, E.M.2
  • 110
    • 0015794743 scopus 로고
    • Recovery of feeding and drinking by rats after intraventricular 6-hydroxydopamine or lateral hypothalamic lesions
    • Zigmond M.J., Stricker E.M. Recovery of feeding and drinking by rats after intraventricular 6-hydroxydopamine or lateral hypothalamic lesions. Science 1973, 182:717-720.
    • (1973) Science , vol.182 , pp. 717-720
    • Zigmond, M.J.1    Stricker, E.M.2


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