Spatial learning in rats is impaired after degeneration of the nigrostriatal dopaminergic system

Movement Disorders

Volumn 18, Issue 8, 2003, Pages 860-871

  Mura, Anna ^a   Feldon, Joram ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

6 OHDA; Bilateral lesions; Dopamine; Nigrostrital system; Striatum; Water maze

Indexed keywords

DOPAMINE; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; ESCAPE BEHAVIOR; LATENT PERIOD; LEARNING; LEARNING DISORDER; MALE; MAZE TEST; MEMORY; NERVE DEGENERATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; SENSORIMOTOR NEUROPATHY; SWIMMING; SWIMMING POOL; TASK PERFORMANCE; TRAINING;

ANIMALS; CORPUS STRIATUM; DOPAMINE; MALE; MAZE LEARNING; NERVE DEGENERATION; RATS; RATS, WISTAR; SPACE PERCEPTION; SPATIAL BEHAVIOR; SUBSTANTIA NIGRA; VISUAL PERCEPTION;

EID: 0041472606     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.10472     Document Type: Article

References (36)

1. Jellinger KA. Post mortem studies in Parkinson's disease: is it possible to detect brain areas for specific symptoms? J Neural Transm 1999;56:1-29.
2. Dubois B, Pillon B. Do cognitive changes of Parkinson's disease result from dopamine depletion? J Neural Transm 1995;45:27-34.
3. Robbins TW. Refining the taxonomy of memory. Science 1996; 273:1353-1354.
4. Graybiel AM. The basal ganglia and chunking of action repertoires. Neurobiol Learn Mem 1998;70:119-136.
5. Levin BE. Spatial cognition in Parkinson's disease. Alzheimer Dis Assoc Disord 1990;4:161-170.
6. Brown LL, Schneider JS, Lidsky TI. Sensory and cognitive functions of the basal ganglia. Curr Opin Neurobiol 1997;7:157-163.
7. Zis AP, Fibiger HC, Phillips AG. Reversal by L-dopa of impaired learning due to destruction of the dopaminergic nigro-neostriatal projection. Science 1974;185:960-962.
8. Mason ST, Iversen SD. Learning impairment in rats after 6-hydroxydopamine-induced depletion of brain catecholamines. Nature 1974;248:697-698.
9. Plech A, Herman ZS, Brus R, Drybanski A. The impairment of learning of conditioned avoidance response in rats after 6-hydroxydopamine. Acta Nerv Super (Praha) 1975;17:176-178.
10. Derevenco P, Baciu I, Stoica N, Sovrea I, Vitebski V, Vaida A, Zdrenghea V. Action of 6-hydroxydopamine on two parameters of motor learning. Physiologie 1980;17:211-215.
11. Ungerstedt U. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 1968;5:107-110.
12. Fibiger HC, Phillis AG, Zis AP. Deficits in instrumental responding after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projection. Pharmacol Biochem Behav 1974;2:87-96.
13. Price MT, Fibiger HC. Discriminated escape learning and response to electric shock after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projection. Pharmacol Biochem Behav 1975;3:285-290.
14. Smith GP, Levin BE, Ervin GN. Loss of active avoidance of responding after lateral hypothalamic injections of 6-hydroxydopamine. Brain Res 1975;88:483-498.
15. Keefe KA, Salamone JD, Zigmond MJ, Stricker EM. Paradoxical kinesia in parkinsonism is not caused by dopamine release. Studies in an animal model. Arch Neurol 1989;46:1070-1075.
16. Morris R. Development of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984;11:47-60.
17. Hagan JJ, Alpert JE, Morris RGM, Iversen SD. The effects of central catecholamine depletions on spatial learning in rats. Behav Brain Res 1983;9:83-104.
18. Whishaw IQ, Dunnet SB. Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues. Behav Brain Res 1985;18: 11-29.
19. Ranje C, Ugerstedt U. Lack of acquisition in dopamine denervated animals tested in an underwater Y-maze. Brain Res 1977;134:95-111.
20. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Fourth ed. San Diego: Academic Press; 1998.
21. Miklyaeva EI, Castaneda E, Whishaw IQ. Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments. J Neurosci 1994;14: 7148-7158.
22. Muir GD, Whishaw IQ. Ground reaction forces in locomoting hemi-parkinsonian rats: a definitive test for impairments and compensations. Exp Brain Res 1999;126:307-314.
23. Fornaguera J, Carey RJ, Huston JP, Schwarting RK. Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion. Brain Res 1994;664:178-188.
24. Abrous DN. Behavioral recovery after unilateral lesion of the dopaminergic mesotelencephalic pathway: effect of repeated testing. Neuroscience 1998;84:213-221.
25. Ungerstedt U. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand 1971;367:95-122.
26. Zigmond M, Stricker E. Deficits in feeding behavior after intraventricular injection of 6-hydroxydopamine in rats. Science 1972; 177:1211-1214.
27. Devan BD, McDonald RJ, White NM. Effects of medial and lateral caudate-putamen lesions on place- and cue-guided behaviors in the water maze: relation to thigmotaxis. Behav Brain Res 1999;100: 5-14.
28. Agid Y, Javoy F, Glowinski J, Bouvet D, Sotelo C. Injection of 6-hydroxydopamine into the substantia nigra of the rat. II. Diffusion and specificity. Brain Res 1973;58:291-301.
29. Willis GL, Singer G, Evans BK. Intracranial injections of 6-OHDA. Comparison of catecholamines-depleting effects of different volumes and concentrations. Pharmacol Biochem Behav 1976;5:207-213.
30. Gesi M, Soldani P, Giorgi FS, Santinami A, Bonaccorsi I, Fornai F. The role of the locus coeruleus in the development of Parkinson's disease. Neurosci Biobehav Rev 2000;24:655-668.
31. Reader TA, Dewar KM. Effects of denervation and hyperinnervation on dopamine and serotonin system in the rat neostriatum: implication for human Parkinson's disease. Neurochem Int 1999;34:1-21.
32. Agid Y, Graybiel AM, Ruberg M, Hirsch E, Blin J, Dubois B, Javoy-Agid F. The efficacy of levodopa treatment declines in the course of Parkinson's disease: do nondopaminergic lesions play a role? Adv Neurol 1990;53:83-100
33. Pisa M, Fibiger HC. Evidence against a role of the rat's dorsal noradrenergic bundle in selective attention and place memory. Brain Res 1983;272:319-329
34. Sahgal A, Keith AB, Lloyd S, Kerwin JM, Perry EK, Edwardson JA. Memory following cholinergic (NBM) and noradrenergic (DNAB) lesions made singly or in combination: potentiation of disruption by scopolamine. Pharmacol Biochem Behav 1990;37: 597-605.
35. Ruotsalainen S, Miettinen R, Macdonald E, Riekkinen M, Sirvio J. The role of the dorsal raphe-serotonergic system and cholinergic receptors in the modulation of working memory. Neurosci Biobehav Rev 1998;22:21-31.
36. Nieoullon A. Dopamine and the regulation of cognition and attention. Prog Neurobiol 2002;67:58-83.