Differential effects of three 5-HT receptor antagonists on the performance of rats in attentional and working memory tasks

European Neuropsychopharmacology

Volumn 7, Issue 2, 1997, Pages 99-108

  Ruotsalainen, Sirja ^a   Sirviö, Jouni ^a   Jäkälä, Pekka ^a,b   Puumala, Tarja ^a   MacDonald, Ewen ^a   Riekkinen Sr , Paavo ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Arousal; Attention; Memory; Operant behaviour; Serotonergic

Indexed keywords

KETANSERIN; METHYSERGIDE; METITEPINE; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1C RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; ATTENTION; BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; INSTRUMENTAL CONDITIONING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTIVATION; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEDATION; SUBCUTANEOUS DRUG ADMINISTRATION; TASK PERFORMANCE; WORKING MEMORY;

ANIMALS; ATTENTION; DOSE-RESPONSE RELATIONSHIP, DRUG; KETANSERIN; MALE; MEMORY; METHYSERGIDE; RATS; RATS, WISTAR; SEROTONIN ANTAGONISTS; TASK PERFORMANCE AND ANALYSIS;

EID: 0030909398     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(96)00389-6     Document Type: Article

References (40)

1. Altman, H.J. and Normile, H.J. (1988) What is the nature of the role of serotonergic system in learning and memory: Prospects for the development of an effective treatment strategy for senile dementia. Neurobiol. Aging 9, 627-638.
2. Beatty, W.W. and Rush, J.R. (1983) Spatial working memory in rats: Effects of monoaminergic antagonists. Pharmacol. Biochem. Behav. 18, 7-12.
3. Blundell, J.E. (1984) Serotonin and appetite. Neuropharmacology 23, 1537-1551.
4. Boess, F.G. and Martin, I.L. (1994) Molecular biology of 5-HT receptors. Neuropharmacology 33, 275-317.
5. Carli, M., Robbins, T.W., Evenden, J.L. and Everitt, B.J. (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction time task in rats: Implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav. Brain Res. 9, 361-380.
6. Carli, M. and Samanin, R. (1992) Serotonin-2 receptor agonists and serotonergic anorectic drugs affect rats' performance differently in a five-choice serial reaction time task. Psychopharmacology 106, 228-234.
7. Cole, B.J. and Robbins, T.W. (1992) Forebrain norepinephrine: Role in controlled information processing in the rat. Neuropsychopharmacology 7, 129-142.
8. Decker, M.W. and McGaugh, J.L. (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7, 151-168.
9. Dunnett, S.B. (1990) Role of prefrontal cortex and striatal output systems in short-term memory deficits associated with ageing, basal forebrain lesions and cholinergic-rich grafts. Can. J. Psychol. 44, 210-232.
10. Dunnett, S.B., Evenden, J.L. and Iversen, S.D. (1988) Delay-dependent short-term memory deficits in aged rats. Psychopharmacology 96, 174-180.
11. Handley, S.L. and McBlane, J.W. (1993) 5-HT drugs in animal models of anxiety. Psychopharmacology 112, 13-20.
12. 1B receptor "knock-out": Pharmacological and behavioral consequences. Soc. Neurosci. Abstr. 19, 632.
13. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, PR., Martin, G.R., Mylecharane, E.J., Saxena, P.R. and Humphrey, P.P.A. (1994) International Union of Pharmacology - classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46, 157-203.
14. Jacobs, B.L., Wise, W.D. and Taylor, K.M. (1974) Differential behavioral and neurochemical effects following lesions of the dorsal or median raphe nuclei in rats. Brain Res. 79, 353-361.
15. Jacobs, B.L., Trimbach, C., Eubanks, E.E. and Trulson M.M. (1975) Hippocampal mediation of raphe lesion- and PCPA-induced hyperactivity in the rat. Brain Res. 94, 253-261.
16. Jacobs, B.L. and Azmitia, E.C. (1992) Structure and function of the brain serotonin system. Physiol. Rev. 72, 165-229.
17. Jacoby, J.H. and Lyttle, L.D. (Eds.) (1978) Serotonin Neurotoxins. Ann. N.Y. Acad. Sci. Vol. 305. The New York Academy of Sciences, New York.
18. Jäkälä, P., Sirviö, J., Jolkkonen, J., Riekkinen, P., Jr., Ascady, L. and Riekkinen, P. (1992) The effects of p-chlorophenylalanine induced serotonin synthesis inhibition on the performance of a 5-choice serial reaction time task in rats; the effects of different parametric manipulations and muscarinic blockade. Behav. Brain Res. 51, 29-40.
19. Jäkälä, P., Sirviö, J., Riekkinen, P., Jr. and Riekkinen, P. (1993) Effects of p-chlorophenylalanine and methysergide on the performance of a working memory task. Pharmacol. Biochem. Behav. 44, 411-418.
20. 2 receptor subtype specific drugs. Eur. J. Pharmacol. 282, 39-55.
21. 3H-ligand for serotonin 2 receptor binding sites. Binding properties, brain distribution and functional role. Mol. Pharmacol. 21, 301-314.
22. 2 receptors. Life Sci. 28, 1015-1022.
23. Lyness, W.H. and Moore, K.E. (1981) Destruction of 5-hydroxytryptaminergic neurons and the dynamics of dopamine in nucleus accumbens septi and other brain regions of the rat. Neuropharmacology 20, 327-334.
24. Markowska, A.L. and Wenk, G.L. (1991) Serotonin influences the behavioural recovery of rats following nucleus basalis lesions. Pharmacol. Biochem. Behav. 38, 731-737.
25. Marsden, C.A. (1989) 5-Hydroxytryptamine receptor subtypes and new anxiolytic drugs: An appraisal. In: Tyrer, P. (Eds.) Psychopharmacology of Anxiety. Oxford University Press, Oxford, pp. 3-27.
26. McCormick, D.A. (1992) Neurotransmitter actions in the thalamus and cerebral cortex. J. Clin. Neurophysiol. 9, 212-223.
27. Middlemiss, D.N. and Tricklebank, M.D. (1992) Centrally active 5-HT receptor agonists and antagonists. Neurosci. Biobehav. Rev. 16, 75-82.
28. Pazos, A. and Palacios, J.M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346, 205-230.
29. Pazos, A., Cortes, R. and Palacios, J.M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-2 receptors. Brain Res. 346, 231-249.
30. Richter-Levin, G. and Segal, M. (1992) The contribution of the serotonergic innervation of the hippocampus to the effects of combined cholinergic/serotonergic deficits. In: Levin, E.D., M.W. Decker and L.L. Butcher (Eds.), Neurotransmitter Interactions and Cognitive Function, Birkhäuser, Boston, pp. 228-239.
31. Riekkinen, M., Riekkinen, P., Sirviö, J. and Riekkinen P., Jr. (1992) Effects of combined methysergide and mecamylamine/scopolamine treatment on spatial navigation. Brain Res. 585, 322-326.
32. Riekkinen, P., Jr., Sirviö, J., Toivanen, L., Riekkinen, M., Lammintausta, R. and Riekkinen P., Sr. (1993) Alpha-1 adrenoceptor antagonist decreases alpha-2 adrenoceptor antagonist-induced high voltage spindle suppression in adult and aged rats. Eur. J. Pharmacol. 235, 317-320.
33. Riekkinen, P.J., Jr., Riekkinen, M.K. and Sirviö J.S. (1994) Serotonin depletion decreases therapeutic effect of THA and nicotine. In: Giacobini, E and R. Becker (Eds.) Alzheimer Disease - Therapeutic Strategies. Birkhäuser, Boston, pp. 212-218.
34. Sakurai, Y. and Wenk, G.L. (1990) The interaction of acetylcholinergic and serotonergic neural systems on performance in a continuous non-matching to sample task. Brain Res. 519, 118-121.
35. Sahgal, A. and Keith, A.B. (1993) Combined serotonergic-cholinergic lesions do not disrupt memory in rats. Pharmacol. Biochem. Behav. 45, 995-1001.
36. Sirviö, J., Riekkinen, P., Jr., Jäkälä, P. and Riekkinen, P.J. (1994) Experimental studies on the role of serotonin in cognition (Review). Prog. Neurobiol. 43, 363-379.
37. Steriade, M., McCormick, D.A. and Sejnowski, T.J. (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262, 679-685.
38. Vanderwolf, C.H. (1989) A general role for serotonin in the control of behavior: Studies with intracerebral 5,7-dihydroxytryptamine. Brain Res. 504, 192-198.
39. Watson, N., Hargreaves, E., Penava, D., Eckel, L. and Vanderwolf, C.H. (1992) Serotonin-dependent cerebral activation: Effects of methiothepin and other serotonergic antagonists. Brain Res. 597, 16-23.
40. Whitaker-Azmitia, P.M. and Peroutka, S.J. (Eds.) (1990) The Neuropharmacology of Serotonin. Ann NY Acad Sci, Vol. 600. New York Academy of Sciences, New York.