Splice-site mutations cause Rrp6-mediated nuclear retention of the unspliced RNAs and transcriptional down-regulation of the splicing-defective genes

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Eberle, Andrea B ^a   Hessle, Viktoria ^a   Helbig, Roger ^a   Dantoft, Widad ^a   Gimber, Niclas ^a   Visa, Neus ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; MESSENGER RNA; MUTANT PROTEIN; NUCLEAR RNA; RIBONUCLEASE; RIBONUCLEASE RRP6; RNA POLYMERASE II; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; RRP6 PROTEIN, DROSOPHILA;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; IN VIVO STUDY; INTRON; NONHUMAN; POLYADENYLATION; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN PROCESSING; RNA INTERFERENCE; RNA SPLICING; TRANSCRIPTION REGULATION; WILD TYPE; ANIMAL; CELL LINE; CELL NUCLEUS; FLUORESCENCE IN SITU HYBRIDIZATION; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

DROSOPHILA MELANOGASTER; EUKARYOTA; HEXAPODA; METAZOA; SACCHAROMYCES CEREVISIAE;

ANIMALS; BETA-GLOBINS; CELL LINE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA SPLICING; RNA, MESSENGER;

EID: 77955376931     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011540     Document Type: Article

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