The yin and yang of the exosome

Trends in Cell Biology

Volumn 12, Issue 2, 2002, Pages 90-96

  Butler, J Scott ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXORIBONUCLEASE; MESSENGER RNA; POLYADENYLATED RNA; RIBOSOME RNA; RNA PRECURSOR; UNCLASSIFIED DRUG;

CYTOPLASM; ENZYME ACTIVITY; EXOSOME; HUMAN; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; RNA DEGRADATION; RNA PROCESSING; RNA TRANSCRIPTION;

ANIMALS; EXORIBONUCLEASES; HUMANS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; RNA, RIBOSOMAL; RNA, SMALL NUCLEAR; RNA, SMALL NUCLEOLAR;

EUKARYOTA;

EID: 0036469214     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02225-5     Document Type: Review

References (43)

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4. Comparative sequence analysis of ribonucleases HII, III, II, PH and D
5. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3¢fi5¢ exoribonucleases
6. Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8S rRNA 3¢ end formation
7. Identification of protein components reactive with anti-PM/Scl autoantibodies
8. Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes
9. The yeast exosome and human PM-Scl are related complexes of 3¢fi5¢ exonucleases
10. Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells
11. The exosome of Trypanosoma brucei
12. Three novel components of the human exosome
13. The 3¢ to 5¢ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3¢ to 5¢ exonucleases of the exosome complex
14. Function of the Ski4p/Csl4p and Ski7p proteins in the 3¢-5¢ degradation of mRNA
15. The yeast exosome and human PM-Scl are related complexes of 3¢-5¢ exonucleases
16. The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA
17. Degradation of ribosomal RNA precursors by the exosome
18. Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3¢ end formation of 5.8S rRNA in Saccharomyces cerevisiae
19. Yeast exosome mutants accumulate 3¢-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
20. Functions of the exosome in rRNA, snoRNA and snRNA synthesis
21. A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA
22. Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3¢-processing apparatus
23. Evidence that the SKI antiviral system of Saccharomyces cerevisiae acts by blocking expression of viral mRNA
24. Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis
25. The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-poly(A) mRNA in Saccharomyces cerevisiae
26. The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo
27. Ski7p G protein interacts with the exosome and the Ski complex for 3¢ to 5¢ mRNA decay in yeast
28. Identification of a regulated pathway for nuclear pre-mRNA turnover
29. A nuclear 3¢-5¢ exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p
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31. The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation
32. Inefficient processing impairs release of RNA from the site of transcription
33. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription
34. Quality control of mRNA 3¢-end processing requires the nuclear exosome
35. The exosome: A proteasome for RNA?
36. Musing on the structural organization of the exosome complex
37. Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis
38. Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p
39. Composition and functional characterization of yeast 66S ribosome assembly intermediates
40. Identification of a 60S pre-ribosomal particle that is closely linked to nuclear export
41. Messenger RNAs are recruited for nuclear export during transcription
42. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
43. The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex