Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

Neuropharmacology

Volumn 42, Issue 2, 2002, Pages 143-153

  Lazzaro, J T ^a   Paternain, A V ^b   Lerma, J ^b   Chenard, B L ^c   Ewing, F E ^a   Huang, J ^a   Welch, W M ^a   Ganong, A H ^a   Menniti, F S ^a  

^a PFIZER INC   (United States)

^b INSTITUTO CAJAL   (Spain)

^c NEUROGEN CORPORATION   (United States)

Author keywords

AMPA receptor antagonist; AMPA receptors; Atropisomer; CP 465,022; Kainate receptors; Noncompetitive antagonists

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 3 (2 CHLOROPHENYL) 2 [2 (6 DIETHYLAMINOMETHYLPYRIDIN 2 YL)VINYL] 6 FLUORO 3H QUINAZOLIN 4 ONE; 6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CP 465022; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; EMBRYO; GRANULE CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CEREBELLUM; CEREBRAL CORTEX; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HUMANS; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; QUINAZOLINES; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036166553     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00170-8     Document Type: Article

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