Nonsteroidal anti-inflammatory drugs for wounds: Pain relief or excessive scar formation?

Mediators of Inflammation

Volumn 2010, Issue , 2010, Pages

  Chen, Chien Sheng ^b   Su, Wen Hsiang ^a,b   Cheng, Ming Huei ^c   Lee, Wen Ling ^b,c,d   Tsou, Tsung Shan ^b   Chang, Wen Hsun ^c,e   Wang, Peng Hui ^b,c,e  

^a Yee Zen Hospital   (Taiwan)

^b NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE RECEPTOR ANTAGONIST; FLUOROURACIL; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E1; PROSTAGLANDIN E2; SILICONE GEL; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTAGONIST; UNCLASSIFIED DRUG;

ANALGESIA; BURN; BURN SCAR; CELL FUNCTION; CELL PROLIFERATION; COMPRESSION THERAPY; CRYOTHERAPY; CYTOKINE PRODUCTION; DEBRIDEMENT; DISEASE MODEL; EXTRACELLULAR MATRIX; HUMAN; HYPERTROPHIC SCAR; IN VITRO STUDY; IN VIVO STUDY; KELOID; MOLECULAR MECHANICS; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; REVIEW; SCAR FORMATION; SKIN FIBROBLAST; SKIN INFLAMMATION; SKIN SCAR; VAPORIZATION; WOUND; WOUND HEALING; ANIMAL; CYTOLOGY; DRUG EFFECT; INFLAMMATION; METABOLISM; PAIN; PATHOLOGY; PATHOPHYSIOLOGY; SCAR; SKIN;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CICATRIX; CICATRIX, HYPERTROPHIC; HUMANS; INFLAMMATION; PAIN; SKIN; WOUND HEALING;

EID: 77955342138     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2010/413238     Document Type: Review

References (63)

1. Sandulache V. C., Parekh A., Li-Korotky H., Dohar J. E., Hebda P. A., Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)- 1-induced collagen synthesis Wound Repair and Regeneration 2007 15 1 122 133
2. Sehgal R., Kumar V. L., Calotropis procera latex-induced inflammatory hyperalgesiaeffect of antiinflammatory drugs Mediators of Inflammation 2005 2005 4 216 220
3. Park J. Y., Pillinger M. H., Abramson S. B., Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases Clinical Immunology 2006 119 3 229 240
4. Mengle-Gaw L. J., Schwartz B. D., Cyclooxygenase-2 inhibitors: promise or peril? Mediators of Inflammation 2002 11 5 275 286
5. Reish R. G., Eriksson E., Scar treatments: preclinical and clinical studies Journal of the American College of Surgeons 2008 206 4 719 730
6. Aarabi S., Longaker M. T., Gurtner G. C., Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS Medicine 2007 4 9, article e234
7. Butler P. D., Longaker M. T., Yang G. P., Current progress in keloid research and treatment Journal of the American College of Surgeons 2008 206 4 731 741
8. Henry G., Garner W. L., Inflammatory mediators in wound healing Surgical Clinics of North America 2003 83 3 483 507
9. Reish R. G., Eriksson E., Scars: a review of emerging and currently available therapies Plastic and Reconstructive Surgery 2008 122 4 1068 1078
10. Atiyeh B. S., Costagliola M., Hayek S. N., Keloid or hypertrophic scar: the controversy: review of the literature Annals of Plastic Surgery 2005 54 6 676 680
11. Ting S. B., Caddy J., Hislop N., Wilanowski T., Auden A., Zhao L.-L., Ellis S., Kaur P., Uchida Y., Holleran W. M., Elias P. M., Cunningham J. M., Jane S. N., A homolog of Drosophila grainy head is essential for epidermal integrity in mice Science 2005 308 5720 411 413
12. Burrington J. D., Wound healing in the fetal lamb Journal of Pediatric Surgery 1971 6 5 523 528
13. Slemp A. E., Kirschner R. E., Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management Current Opinion in Pediatrics 2006 18 4 396 402
14. Winter G. D., Some factors affecting skin and wound healing Journal of Tissue Viability 2006 16 2 20 23
15. Faler B. J., Macsata R. A., Plummer D., Mishra L., Sidawy A. N., Transforming growth factor-beta and wound healing Perspectives in Vascular Surgery and Endovascular Therapy 2006 18 1 55 62
16. Chen C.-L., Shuan S. H., Jung S. H., Cellular heparan sulfate negatively modulates transforming growth factor-β 1 (TGF-β 1) responsiveness in epithelial cells Journal of Biological Chemistry 2006 281 17 11506 11514
17. Shimizu T., Kanai K.-I., Kyo Y., Asano K., Hisamitsu T., Suzaki H., Effect of tranilast on matrix metalloproteinase production from neutrophils in-vitro Journal of Pharmacy and Pharmacology 2006 58 1 91 99 (Pubitemid 43042000)
18. Hsu Y.-C., Hsiao M., Chien Y. W., Lee W.-R., Exogenous nitric oxide stimulated collagen type I expression and TGF-β 1 production in keloid fibroblasts by a cGMP-dependent manner Nitric Oxide 2007 16 2 258 265
19. Xia W., Phan T.-T., Lim I. J., Longaker M. T., Yang G. P., Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation Journal of Surgical Research 2006 135 1 156 163
20. Sato M., Upregulation of the Wnt/β -catenin pathway induced by transforming growth factor-β in hypertrophic scars and keloids Acta Dermato-Venereologica 2006 86 4 300 307
21. Campaner A. B., Ferreira L. M., Gragnani A., Bruder J. M., Cusick J. L., Morgan J. R., Upregulation of TGF-β1 expression may be necessary but is not sufficient for excessive scarring Journal of Investigative Dermatology 2006 126 5 1168 1176
22. Suzawa H., Kikuchi S., Arai N., Koda A., The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts Japanese Journal of Pharmacology 1992 60 2 91 96
23. Moulin V., Larochelle S., Langlois C., Thibault I., Lopez-Vall C. A., Roy M., Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors Journal of Cellular Physiology 2004 198 3 350 358
24. Chipev C. C., Simon M., Phenotypic differences between dermal fibroblasts from different body sites determine their responses to tension and TGFbeta1 BMC Dermatology 2002 2 1, article 13
25. Shin D., Minn K. W., The effect of myofibroblast on contracture of hypertrophic scar Plastic and Reconstructive Surgery 2004 113 2 633 640
26. Spiekstra S. W., Breetveld M., Rustemeyer T., Scheper R. J., Gibbs S., Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes Wound Repair and Regeneration 2007 15 5 708 717
27. Jagadeesan J., Bayat A., Transforming growth factor beta (TGF ) and keloid disease International Journal of Surgery 2007 5 4 278 285
28. Kuo Y.-R., Wu W.-S., Wang F.-S., Flashlamp pulsed-dye laser suppressed TGF-β 1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway Lasers in Surgery and Medicine 2007 39 4 358 364
29. Zhou L.-J., Inoue M., Gunji H., Ono I., Kaneko F., Effects of prostaglandin E1 on cultured dermal fibroblasts from normal and hypertrophic scarred skin Journal of Dermatological Science 1997 14 3 217 224 (Pubitemid 27092975)
30. Huang S. S., Liu Q., Johnson F. E., Konish Y., Huang J. S., Transforming growth factor peptide antagonists and their conversion to partial agonists Journal of Biological Chemistry 1997 272 43 27155 97159
31. Vuolteenaho K., Koskinen A., Kukkonen M., Nieminen R., Pivrinta U., Moilanen T., Moilanen E., Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage-mediator role of NO in leptin-induced PGE 2, IL-6, and IL-8 production Mediators of Inflammation 2009 2009 10
32. Sasaki M., Kashima M., Ito T., Watanabe A., Izumiyama N., Sano M., Kagaya M., Shioya T., Miura M., Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1β and TNF-α Mediators of Inflammation 2000 9 3-4 155 160
33. Sampey A. V., Hutchinson P., Morand E. F., Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes Mediators of Inflammation 2000 9 3-4 125 132
34. Homaidan F. R., Zhao L., Chakroun I., Martin C. A., Burakoff R., The mechanisms of action of interleukin-1 on rabbit intestinal epithelial cells Mediators of Inflammation 1999 8 4-5 189 197
35. Yeh F.-L., Shen H.-D., Lin M.-W., Chang C.-Y., Tai H.-Y., Huang M.-H., Keloid-derived fibroblasts have a diminished capacity to produce prostaglandin E2 Burns 2006 32 3 299 304
36. Hayashi T., Nishihira J., Koyama Y., Sasaki S., Yamamoto Y., Decreased prostaglandin E2 production by inflammatory cytokine and lower expression of EP2 receptor result in increased collagen synthesis in keloid fibroblasts Journal of Investigative Dermatology 2006 126 5 990 997
37. Shah M., Foreman D. M., Ferguson M. W. J., Control of scarring in adult wounds by neutralising antibody to transforming growth factor The Lancet 1992 339 8787 213 214
38. Ren F., Grazianetti P., Cannas M., Effects of mechanical compression on hypertrophic scars: prostaglandin E2 release Burns 2001 27 3 215 218
39. Li F., Huang Q., Chen J., Peng Y., Roop D. R., Bedford J. S., Li C. Y., Apoptotic cells activate the phoenix rising pathway to promote wound healing and tissue regeneration Science signaling 2010 3 110: ra13
40. Zhou L.-J., Inoue M., Ono I., Kaneko F., The mode of action of prostaglandin (PG) I1 analog, SM-10906, on fibroblasts of hypertrophic scars is similar to PGE1 in its potential role of preventing scar formation Experimental Dermatology 1997 6 6 314 320
41. Suzawa H., Kikuchi S., Ichikawa K., Koda A., Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages Japanese Journal of Pharmacology 1992 60 2 85 90
42. Darmani H., Crossan J., McLellan S. D., Meek D., Curtis A., Expression of nitric oxide synthase and transforming growth factor-beta in crush-injured tendon and synovium Mediators of Inflammation 2004 13 5-6 299 305
43. Kumar V. L., Shivkar Y. M., Involvement of prostaglandins in inflammation induced by latex of Calotropis procera Mediators of Inflammation 2004 13 3 151 155
44. van Dijk A. P. M., Keuskamp Z. J., Wilson J. H. P., Zijlstra F. J., Sequential release of cytokines, lipid mediators and nitric oxide in experimental colitis Mediators of Inflammation 1995 4 3 186 190
45. Wang X.-J., Han G., Owens P., Siddiqui Y., Li A. G., Role of TGFβ-mediated inflammation in cutaneous wound healing Journal of Investigative Dermatology Symposium Proceedings 2006 11 1 112 117
46. Aarabi S., Bhatt K. A., Shi Y., Paterno J., Chang E. I., Loh S. A., Holmes J. W., Longaker M. T., Yee H., Gurtner G. C., Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis FASEB Journal 2007 21 12 3250 3261 (Pubitemid 47565543)
47. Huang J. S., Wang Y. H., Ling T. Y., Chuang S. S., Johnson F. E., Huang S. S., Synthetic TGF-beta antagonist accelerates wound healing and reduces scarring The FASEB Journal 2002 16 10 1269 1270
48. Moore H. D., Cunningham F. M., Mediators of increased blood flow in porcine skin Mediators of Inflammation 1992 1 1 55 59
49. Singer A. J., Huang S. S., Huang J. S., McClain S. A., Romanov A., Rooney J., Zimmerman T., A novel TGF-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns Journal of Burn Care and Research 2009 30 2 329 334
50. Cooper A. L., Turnbull A. V., Hopkins S. J., Rothwell N. J., Dietary n-3 fatty acids inhibit fever induced by inflammation in the rat Mediators of Inflammation 1994 3 5 353 357
51. Ogawa R., The most current algorithms for the treatment and prevention of hypertrophic scars and keloids Plastic and Reconstructive Surgery 2010 125 2 557 568
52. Aggarwal H., Saxena A., Lubana P. S., Mathur R. K., Jain D. K., Treatment of keloids and hypertrophic scars using bleom Journal of Cosmetic Dermatology 2008 7 1 43 49
53. Atkinson J.-A.M., McKenna K. T., Barnett A. G., McGrath D. J., Rudd M., A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic sear formation in surgical incisions that traverse Langer's skin tension lines Plastic and Reconstructive Surgery 2005 116 6 1648 1656
54. Anzarut A., Olson J., Singh P., Rowe B. H., Tredget E. E., The effectiveness of pressure garment therapy for the prevention of abnormal scarring after burn injury: a meta-analysis Journal of Plastic, Reconstructive and Aesthetic Surgery 2009 62 1 77 84
55. O'Brien L., Pandit A., Silicon gel sheeting for preventing and treating hypertrophic and keloid scars Cochrane Database of Systematic Reviews 2006 1
56. Lim Y., Phung A. D., Corbacho A. M., Aung H. H., Maioli E., Reznick A. Z., Cross C. E., Davis P. A., Valacchi G., Modulation of cutaneous wound healing by ozone: differences between young and aged mice Toxicology Letters 2006 160 2 127 134
57. Valacchi G., Fortino V., Bocci V., The dual action of ozone on the skin British Journal of Dermatology 2005 153 6 1096 1100
58. Widgerow A. D., Chait L. A., Stals P. J., Stals R., Candy G., Multimodality scar management program Aesthetic Plastic Surgery 2009 33 4 533 543
59. Lau K., Paus R., Tiede S., Day P., Bayat A., Exploring the role of stem cells in cutaneous wound healing Experimental Dermatology 2009 18 11 921 933
60. Braiman-Wiksman L., Solomonik I., Spira R., Tennenbaum T., Novel insights into wound healing sequence of events Toxicologic Pathology 2007 35 6 767 779
61. Ku H.-O., Jeong S.-H., Kang H.-G., Pyo H.-M., Cho J.-H., Son S.-W., Yun S.-M., Ryu D.-Y., Gene expression profiles and pathways in skin inflammation induced by three different sensitizers and an irritant Toxicology Letters 2009 190 2 231 237
62. Ansaloni L., Brundisini R., Morino G., Kiura A., Prospective, randomized, comparative study of Misgav Ladach versus traditional cesarean section at Nazareth Hospital, Kenya World Journal of Surgery 2001 25 9 1164 1172
63. Darj E., Nordstrm M.-L., The Misgav Ladach method for cesarean section compared to the Pfannenstiel method Acta Obstetricia et Gynecologica Scandinavica 1999 78 1 37 41