Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes

Wound Repair and Regeneration

Volumn 15, Issue 5, 2007, Pages 708-717

  Spiekstra, Sander W ^a   Breetveld, Melanie ^a   Rustemeyer, Thomas ^a   Scheper, Rik J ^a   Gibbs, Susan ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; RANTES; SCATTER FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; DERMIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL; SKIN AUTOGRAFT; SKIN FIBROBLAST; WOUND HEALING;

CELL CULTURE TECHNIQUES; CHEMOKINE CCL5; CHEMOKINE CXCL1; COCULTURE TECHNIQUES; EPIDERMIS; FIBROBLASTS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; KERATINOCYTES; SKIN TRANSPLANTATION; SKIN, ARTIFICIAL; TRANSPLANTATION, AUTOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 34848835855     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2007.00280.x     Document Type: Article

References (36)

1. El Ghalbzouri A, Ponec M. Diffusible factors released by fibroblasts support epidermal morphogenesis and deposition of basement membrane components. Wound Repair Regen 2004 12 : 359 67.
2. Kubo K, Kuroyanagi Y. A study of cytokines released from fibroblasts in cultured dermal substitute. Artif Organs 2005 29 : 845 9.
3. Boyce ST, Warden GD. Principles and practices for treatment of cutaneous wounds with cultured skin substitutes. Am J Surg 2002 183 : 445 56.
4. Ehrenreich M, Ruszczak Z. Update on tissue-engineered biological dressings. Tissue Eng 2006 12 : 2407 24.
5. Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. BMJ 2002 324 : 160 3.
6. Jones I, Currie L, Martin RA. Guide to biological skin substitutes. Br J Plast Surg 2002 55 : 185 93.
7. Dinh TL, Veves A. The efficacy of Apligraf in the treatment of diabetic foot ulcers. Plast Reconstr Surg 2006 117 (Suppl.) : 152S 7S.
8. Gibbs S, Hoogenband van den HM, Kirschig G, Richters CD, Spiekstra SW, Breetveld M, Scheper RJ, Boer de EM. Autologous full-thickness skin substitute for healing chronic wounds. Br J Dermatol 2006 155 : 267 74.
9. Marston WA, Hanft J, Norwood P, Pollak R. The efficacy and safety of dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care 2003 26 : 170 15.
10. Pellegrini G, Ranno R, Stracuzzi G, Bondanza S, Guerra L, Zambruno G, Micali G, De Luca M. The control of epidermal stem cells (Holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. Transplantation 1999 68 : 868 79.
11. Long RE, Falabella AF, Valencia I, Eaglstein WH, Kirsner RS. Treatment of refractory, atypical lower extremity ulcers with tissue-engineered skin (Apligraf). Arch Dermatol 2001 137 : 1660 1.
12. Rozen SM, Nahabedian MY, Manson PN. Management strategies for pyoderma gangrenosum: case studies and review of literature. Ann Plast Surg 2001 47 : 310 5.
13. Valencia IC, Falabella AF, Eaglstein WH. Skin grafting. Dermatol Clin 2000 18 : 521 32.
14. Burke JF, Bondoc CC, Quinby WC. Primary burn excision and immediate grafting: a method shortening illness. J Trauma 1974 14 : 389 95.
15. El Ghalbzouri A, Hensbergen P, Gibbs S, Kempenaar J, Schors Rv R, Ponec M. Fibroblasts facilitate reepithelialization in wounded human skin equivalents. Lab Invest 2004 84 : 102 12.
16. Boxman I, Lowik C, Aarden L, Ponec M. Modulation of IL6 production and IL1 activity by keratinocyte-fibroblast interaction. J Invest Dermatol 1993 101 : 316 24.
17. MaasSzabowski N, Shimotoyodome A, Fusenig NE. Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism. J Cell Sci 1999 112 (Part 12) : 1843 53.
18. Goretsky MJ, Harriger MD, Supp AP, Greenhalgh DG, Boyce ST. Expression of interleukin-1alpha, interleukin-6, and basic fibroblast growth factor by cultured skin substitutes before and after grafting to full-thickness wounds in athymic mice. J Trauma 1996 40 : 894 9.
19. Martin P. Wound healing-aiming for perfect skin regeneration. Science 1997 276 : 75 81.
20. Spiekstra SW, Toebak MJ, SampatSardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, von Blomberg BM, Scheper RJ, Bruynzeel DP, Rustemeyer T, Gibbs S. Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. Exp Dermatol 2005 14 : 109 16.
21. Freedberg IM, TomicCanic M, Komine M, Blumenberg M. Keratins and the keratinocyte activation cycle. J Invest Dermatol 2001 116 : 633 40.
22. Cumberbatch M, Dearman RJ, Groves RW, Antonopoulos C, Kimber I. Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL1beta during irritant and allergen-induced cutaneous immune responses. Toxicol Appl Pharmacol 2002 182 : 126 35.
23. Nakae S, Komiyama Y, Narumi S, Sudo K, Horai R, Tagawa Y, Sekikawa K, Matsushima K, Asano M, Iwakura Y. IL1Induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response. Int Immunol 2003 15 : 251 60.
24. Petering H, Kluthe C, Dulkys Y, Kiehl P, Ponath PD, Kapp A, Elsner J. Characterization of the CC chemokine receptor 3 on human keratinocytes. J Invest Dermatol 2001 116 : 549 55.
25. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003 83 : 835 70.
26. Atiyeh BS, Gunn SW, Hayek SN. State of the art in burn treatment. World J Surg 2005 29 : 131 48.
27. Wood FM, Kolybaba ML, Allen P. The use of cultured epithelial autograft in the treatment of major burn injuries: a critical review of the literature. Burns 2006 32 : 395 401.
28. Pellegrini G, Bondanza S, Guerra L, De Luca M. Cultivation of human keratinocyte stem cells: current and future clinical applications. Med Biol Eng Comput 1998 36 : 778 90.
29. StetlerStevenson WG, Seo DW. TIMP-2: an endogenous inhibitor of angiogenesis. Trends Mol Med 2005 11 : 97 103.
30. Bevan D, Gherardi E, Fan TP, Edwards D, Warn R. Diverse and potent activities of HGF/SF in skin wound repair. J Pathol 2004 203 : 831 8.
31. Hansbrough JF, Dore C, Hansbrough WB. Clinical trials of a living dermal tissue replacement placed beneath meshed, split-thickness skin grafts on excised burn wounds. J Burn Care Rehabil 1992 13 : 519 29.
32. Griffiths M, Ojeh N, Livingstone R, Price R, Navsaria H. Survival of Apligraf in acute human wounds. Tissue Eng 2004 10 : 1180 95.
33. Nowinski D, Lysheden AS, Gardner H, Rubin K, Gerdin B, Ivarsson M. Analysis of gene expression in fibroblasts in response to keratinocyte-derived factors in vitro: potential implications for the wound healing process. J Invest Dermatol 2004 122 : 216 21.
34. Smiley AK, Klingenberg JM, Aronow BJ, Boyce ST, Kitzmiller WJ, Supp DM. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin. J Invest Dermatol 2005 125 : 1286 301.
35. Smiley AK, Klingenberg JM, Boyce ST, Supp DM. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns 2006 32 : 135 8.
36. Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, O'Neill LA, Liew FY. ST2 is an inhibitor of interleukin 1 receptor and toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 2004 5 : 373 9.