Neuroprotection in pediatric cardiac surgery: What is on the horizon?

Progress in Pediatric Cardiology

Volumn 29, Issue 2, 2010, Pages 113-122

  Andropoulos, Dean B ^a,b   Brady, Kenneth M ^a,b   Easley, R Blaine ^a,b   Fraser, Charles D ^a,b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Erythropoietin; Magnetic resonance imaging; Neurological injury; Neuroprotection; Pediatric cardiac surgery; Stem cell treatment

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CREATINE KINASE BB; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; NERVE GROWTH FACTOR; NEUROFILAMENT PROTEIN; NEURON SPECIFIC ENOLASE; NEUROTROPHIC FACTOR; PROTEIN S100B; UBIQUITIN THIOLESTERASE; VASCULOTROPIN;

ARTICLE; BRAIN INJURY; CARDIOPULMONARY BYPASS; CONGENITAL HEART DISEASE; ELECTROENCEPHALOGRAM; HEART ARREST; HEART SURGERY; HUMAN; HYPOTHERMIA; ISCHEMIC PRECONDITIONING; MORTALITY; NEAR INFRARED SPECTROSCOPY; NERVOUS SYSTEM INJURY; NEURAL STEM CELL; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN SATURATION; PEDIATRIC CARDIOLOGY; PERIOPERATIVE PERIOD; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; WHITE MATTER;

EID: 77955338640     PISSN: 10589813     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ppedcard.2010.06.005     Document Type: Article

References (71)

1. Creighton D.E., Robertson C.M., Sauve R.S., et al. Neurocognitive, functional, and health outcomes at 5years of age for children after complex cardiac surgery at 6weeks of age or younger. Pediatrics 2007, 120:e478-e486.
2. Majnemer A., Limperopoulos C., Shevell M., Rosenblatt B., Rohlicek C., Tchervenkov C. Long-term neuromotor outcome at school entry of infants with congenital heart defects requiring open-heart surgery. J Pediatr 2006, 148:72-77.
3. Andropoulos D.B., Hunter J.V., Nelson D.P., et al. Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. J Thorac Cardiovasc Surg 2010, 139:543-556.
4. Galli K.K., Zimmerman R.A., Jarvik G.P., et al. Periventricular leukomalacia is common after neonatal cardiac surgery. J Thorac Cardiovasc Surg 2004, 127:692-704.
5. Fuller S., Nord A.S., Gerdes M., et al. Predictors of impaired neurodevelopmental outcomes at one year of age after infant cardiac surgery. Eur J Cardiothorac Surg 2009, 36:40-47.
6. Nelson D.P., Andropoulos D.B., Fraser C.D. Perioperative neuroprotective strategies. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2008, 49-56. [Review].
7. Jöbsis F.F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 1977, 198:1264-1267.
8. Austin E.H., Edmonds H.L., Auden S.M., et al. Benefit of neurophysiologic monitoring for pediatric cardiac surgery. J Thorac Cardiovasc Surg 1997, 114:707-715.
9. Dent C.L., Spaeth J.P., Jones B.V., et al. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg 2005, 130:1523-1530.
10. Brady K.M., Lee J.K., Kibler K.K., et al. Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy. Stroke 2007, 38:2818-2825.
11. Bassan H., Gauvreau K., Newburger J.W. Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res 2005, 57:35-41.
12. Silverstein F.S., Jensen F.E. Neonatal seizures. Ann Neurol 2007, 62:112-120.
13. Rappaport L.A., Wypij D., Bellinger D.C., et al. Relation of seizures after cardiac surgery in early infancy to neurodevelopmental outcome. Boston Circulatory Arrest Study Group. Circulation 1998, 97:773-779.
14. Gaynor J.W., Jarvik G.P., Bernbaum J., et al. The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1year of age after neonatal and infant cardiac surgery. J Thorac Cardiovasc Surg 2006, 131:181-189.
15. Andropoulos D.B., Mizrahi E.M., Hrachovy R.A., et al. Electroencephalographic seizures after neonatal cardiac surgery with high-flow cardiopulmonary bypass. Anesth Analg. 2010, 110:1680-1685.
16. McQuillen P.S., Barkovich A.J., Hamrick S.E., et al. Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects. Stroke 2007, 38(2 Suppl):736-741.
17. Partridge S.C., Vigneron D.B., Charlton N.N., et al. Pyramidal tract maturation after brain injury in newborns with heart disease. Ann Neurol 2006, 59:640-651.
18. McQuillen P.S. Magnetic resonance imaging in congenital heart disease: what to do with what we see and don't see?. Circulation 2009, 119:660-662.
19. Soul J.S., Robertson R.L., Wypij D., et al. Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. J Thorac Cardiovasc Surg 2009, 138:374-381.
20. Limperopoulos C., Tworetzky W., McElhinney D.B., et al. Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation 2010, 121:26-33.
21. Miller S.P., McQuillen P.S., Hamrick S., et al. Abnormal brain development in newborns with congenital heart disease. N Engl J Med 2007, 357:1928-1938.
22. Licht D.J., Shera D.M., Clancy R.R., et al. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg 2009, 137:529-536.
23. Sherlock R.L., McQuillen P.S., Miller S.P. aCCENT. Preventing brain injury in newborns with congenital heart disease: brain imaging and innovative trial designs. Stroke 2009, 40:327-332.
24. Ramaswamy V., Horton J., Vandermeer B., Buscemi N., Miller S., Yager J. Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr Neurol 2009, 40:215-226.
25. Nagdyman N., Grimmer I., Scholz T., Muller C., Obladen M. Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia. Pediatr Res 2003, 54:270-275.
26. Schmitt B., Bauersfeld U., Schmid E.R., et al. Serum and CSF levels of neuron-specific enolase (NSE) in cardiac surgery with cardiopulmonary bypass: a marker of brain injury?. Brain Dev 1998, 20:536-539.
27. Lardner D., Davidson A., McKenzie I., Cochrane A. Delayed rises in serum S100B levels and adverse neurological outcome in infants and children undergoing cardiopulmonary bypass. Paediatr Anaesth 2004, 14:495-500.
28. Jonas R.A. Review of current research at Boston Children's Hospital. Ann Thorac Surg 1993, 56:1467-1472.
29. Lumpkins K.M., Bochicchio G.V., Keledjian K., Simard J.M., McCunn M., Scalea T. Glial fibrillary acidic protein is highly correlated with brain injury. Glial fibrillary acidic protein is highly correlated with brain injury. J Trauma 2008, 65:778-782.
30. Hsu A.A., Fenton K., Weinstein S., Carpenter J., Dalton H., Bell M.J. Neurological injury markers in children with septic shock. Pediatr Crit Care Med 2008, 9:245-251.
31. Ashraf S., Bhattacharya K., Tian Y., Watterson K. Cytokine and S100B levels in paediatric patients undergoing corrective cardiac surgery with or without total circulatory arrest. Eur J Cardiothorac Surg 1999, 16:32-37.
32. Siman R., Toraskar N., Dang A., et al. A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma 2009, 26:1867-1877.
33. Siman R., Roberts V.L., McNeil E., et al. Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. Brain Res 2008, 1213:1-11.
34. Papa L., Akinyi L., Liu M.C., et al. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med 2010, 38:138-144.
35. Wypij D., Newburger J.W., Rappaport L.A., et al. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 2003, 126:1397-1403.
36. Jonas R.A., Bellinger D.C., Rappaport L.A., et al. Relation of pH strategy and developmental outcome after hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1993, 106:362-368.
37. Wypij D., Jonas R.A., Bellinger D.C., et al. The effect of hematocrit during hypothermic cardiopulmonary bypass in infant heart surgery: results from the combined Boston hematocrit trials. J Thorac Cardiovasc Surg 2008, 135:355-360.
38. Goldberg C.S., Bove E.L., Devaney E.J., et al. A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: outcomes for infants with functional single ventricle. J Thorac Cardiovasc Surg Apr 2007, 133(4):880-887.
39. Visconti K.J., Rimmer D., Gauvreau K., et al. Regional low-flow perfusion versus circulatory arrest in neonates: one-year neurodevelopmental outcome. Ann Thorac Surg 2006, 82:2207-2211.
40. Fraser C.D., Andropoulos D.B. Principles of antegrade cerebral perfusion during arch reconstruction in newborns/infants. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2008, 61-68. [Review].
41. Loepke A.W., Soriano S.G. An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg 2008, 106:1681-1707.
42. Anand K.J., Garg S., Rovnaghi C.R., Narsinghani U., Bhutta A.T., Hall R.W. Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res 2007, 62:283-290.
43. Loepke A.W., Priestley M.A., Schultz S.E., McCann J., Golden J., Kurth C.D. Desflurane improves neurologic outcome after low-flow cardiopulmonary bypass in newborn pigs. Anesthesiology 2002, 97:1521-1527.
44. McAuliffe J.J., Loepke A.W., Miles L., Joseph B., Hughes E., Vorhees C.V. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology 2009, 111:533-546.
45. Hudetz J.A., Pagel P.S. Neuroprotection by ketamine: a review of the experimental and clinical evidence. J Cardiothorac Vasc Anesth 2010, 24:131-142.
46. Sato K., Kimura T., Nishikawa T., et al. Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats. Acta Anaesthesiol Scand 2010, 54:377-382.
47. Sanders R.D., Sun P., Patel S., et al. Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain. Acta Anaesthesiol Scand 2009, [Electronic publication ahead of print November 26, 2009].
48. Greeley W.J., Kern F.H., Ungerleider R.M., et al. The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children. J Thorac Cardiovasc Surg 1991, 101:783-794.
49. Bissonnette B., Holtby H.M., Davis A.J., Pua H., Gilder F.J., Black M. Cerebral hyperthermia in children after cardiopulmonary bypass. Anesthesiology 2000, 93:611-618.
50. Laptook A.R. Use of therapeutic hypothermia for term infants with hypoxic-ischemic encephalopathy. Pediatr Clin N Am 2009, 56:601-616.
51. American Heart Association 2005 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC) of pediatric and neonatal patients: pediatric advanced life support. Pediatrics 2006, 117:e1005-e1028.
52. Manole M.D., Kochanek P.M., Fink E.L., Clark R.S. Postcardiac arrest syndrome: focus on the brain. Curr Opin Pediatr 2009, 21:745-750.
53. Pastuszko P., Pirzadeh A., Reade E., et al. The effect of hypothermia on neuronal viability following cardiopulmonary bypass and circulatory arrest in newborn piglets. Eur J Cardiothorac Surg 2009, 35:577-581.
54. Steiger H.J., Hänggi D. Ischaemic preconditioning of the brain, mechanisms and applications. Acta Neurochir (Wien) 2007, 149:1-10.
55. Dirnagl U., Becker K., Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol 2009, 8:398-412.
56. Andropoulos D.B., East D.L., Eble B.K., Stapleton G.E., Chang A.C. Preoperative cerebral oxyhemoglobin saturation in neonates undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology 2005, 103:A1341. [Abstract].
57. Kharbanda R.K., Nielsen T.T., Redington A.N. Translation of remote ischaemic preconditioning into clinical practice. Lancet 2009, 374:1557-1565.
58. McPherson R.J., Juul S.E. Recent trends in erythropoietin-mediated neuroprotection. Int J Dev Neurosci 2008 Feb, 26(1):103-111.
59. Maise K., Li F., Chiong Z.Z. New avenues of exploration for erythropoetin. JAMA 2005, 293:90-95.
60. Liu R., Suzuki A., Guo Z., et al. Intrinsic and extrinsic erythropoetin enhances neuroprotection against ischemia and reperfusion injury in vitro. J Neurochem 2006, 96:1101-1110.
61. Givehchian M., Beschorner R., Ehmann C., et al. Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest. Eur J Cardiothorac Surg 2010, 37:662-668.
62. Juul S. Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo models. Clin Perinatol 2004, 31:129-142.
63. Zhu C., Kang W., Xu F., et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics 2009, 124:e218-e226.
64. Sizonenko S.V., Bednarek N., Gressens P. Growth factors and plasticity. Semin Fetal Neonatal Med 2007, 12:241-249.
65. Ferriero D.M. Neonatal brain injury. N Engl J Med 2004, 351:1985-1995.
66. Schäbitz W.R., Steigleder T., Cooper-Kuhn C.M., et al. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007, 38:2165-2172.
67. Almli C.R., Levy T.J., Han B.H., Shah A.R., Gidday J.M., Holtzman D.M. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp Neurol 2000, 166:99-114.
68. Abe K. Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury. J Cereb Blood Flow Metab 2000, 20:1393-1408.
69. Vawda R., Woodbury J., Covey M., Levison S.W., Mehmet H. Stem cell therapies for perinatal brain injuries. Semin Fetal Neonatal Med 2007, 12:259-272.
70. Fan C.G., Zhang Q.J., Tang F.W., Han Z.B., Wang G.S., Han Z.C. Human umbilical cord blood cells express neurotrophic factors. Neurosci Lett 2005, 380:322-325.
71. Levey A., Glickstein J.S., Kleinman C.S., et al. The impact of prenatal diagnosis of complex congenital heart disease on neonatal outcomes. Pediatr Cardiol 2010, [Electronic publication ahead of print Feb 18, 2010].