2-Phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: Synthesis and pharmacological evaluation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 4905-4916

  Dettmann, Sandra ^a   Szymanowitz, Katrin ^a   Wellner, Anja ^a   Schiedel, Anke ^b   Müller, Christa E ^b   Gust, Ronald ^a,c  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Benzimidazoles; Cytotoxicity; Estrogen receptor

Indexed keywords

2 (4 HYDROXYPHENYL) 1 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYL] 1H BENZIMIDAZOLE; 2 PHENYL 1 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYL] 1H BENZIMIDAZOLE; 4 HYDROXYTAMOXIFEN; 5 HYDROXY 2 (4 HYDROXYPHENYL) 1 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYL] 1H BENZIMIDAZOLE; 5 HYDROXY 2 PHENYL 1 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYL] 1H BENZIMIDAZOLE; 6 HYDROXY 2 (4 HYDROXYPHENYL) 1 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYL] 1H BENZIMIDAZOLE; 6 HYDROXY 2 PHENYL 1 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYL] 1H BENZIMIDAZOLE; AROMATIC COMPOUND; BENZIMIDAZOLE DERIVATIVE; BENZYL DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; HYDROXYL GROUP; PHENYL GROUP; PIPERIDINE DERIVATIVE; RALOXIFENE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PLASMID; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS;

EID: 77955317356     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.016     Document Type: Article

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