Synthesis, structural evaluation, and estrogen receptor interaction of 2,3-diarylpiperazines

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2325-2337

  Gust, Ronald ^a   Keilitz, Roland ^a   Schmidt, Kathrin ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 CHLORO 4 METHOXYPHENYL) 2 (2,6 DICHLORO 4 METHOXYPHENYL)ETHYLENEDIAMINE; 1,2 BIS(2,6 DICHLORO 3 METHOXYPHENYL)ETHYLENEDIAMINE; 1,2 BIS(2,6 DICHLORO 4 METHOXYPHENYL)ETHYLENEDIAMINE; 2 (2 CHLORO 4 HYDROXYPHENYL) 3 (2,6 DICHLORO 4 HYDROXYPHENYL)PIPERAZINE; 2,3 BIS(2 CHLORO 4 HYDROXYPHENYL)PIPERAZINE; 2,3 BIS(2 CHLORO 4 METHOXYPHENYL)PIPERAZINE; 2,3 BIS(2 FLUORO 4 HYDROXYPHENYL)PIPERAZINE; 2,3 BIS(2 FLUORO 4 METHOXYPHENYL)PIPERAZINE; 2,3 BIS(2,6 DICHLORO 3 HYDROXYPHENYL)PIPERAZINE; 2,3 BIS(2,6 DICHLORO 4 HYDROXYPHENYL)PIPERAZINE; 2,3 BIS(4 HYDROXYPHENYL)PIPERAZINE; 2,3 BIS(4 METHOXYPHENYL)PIPERAZINE; ACETIC ANHYDRIDE; BORON DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; ETHER; ETHYLENEDIAMINE DERIVATIVE; N ETHYL 2,3 BIS(2 CHLORO 4 HYDROXYPHENYL)PIPERAZINE; N ETHYL 2,3 BIS(2 FLUORO 4 HYDROXYPHENYL)PIPERAZINE; N,N' DIETHYL 2,3 BIS(2 CHLORO 4 HYDROXYPHENYL)PIPERAZINE; N,N' DIETHYL 2,3 BIS(2 FLUORO 4 HYDROXYPHENYL)PIPERAZINE; N,N' DIETHYL 2,3 BIS(4 HYDROXYPHENYL)PIPERAZINE; OXALIC ACID DERIVATIVE; OXALIC ACID DIMETHYL ESTER; PIPERAZINE DERIVATIVE; PIPERAZINEDIONE; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING COMPETITION; CELL STRAIN MCF 7; CHEMICAL REACTION; CONTROLLED STUDY; DEGRADATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METHYLATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; RECEPTOR AFFINITY; REDUCTION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; CATTLE; CYTOSOL; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; LIGANDS; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATORS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; UTERUS;

EID: 0037161581     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0208368     Document Type: Article

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