Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron

Magnetic Resonance in Medicine

Volumn 63, Issue 5, 2010, Pages 1201-1209

  Jensen, Jens H ^a   Tang, Haiying ^b   Tosti, Christina L ^c   Swaminathan, Srirama V ^d   Nunez, Alvaro ^a   Hultman, Kristi ^e   Szulc, Kamila U ^a   Wu, Ed X ^f   Kim, Daniel ^a   Sheth, Sujit ^c   Brown, Truman R ^c   Brittenham, Gary M ^c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d PHILIPS HEALTHCARE   (United States)

^e University of Hong Kong ^*  (United States)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Ferritin; Hemosiderin; Iron overload; Liver; MRI; Quantification

Indexed keywords

CHLORINE COMPOUNDS; DIGITAL STORAGE; LIVER; MAGNETIC RESONANCE IMAGING; MANGANESE COMPOUNDS; PHANTOMS; SPIN POLARIZATION;

FERRITIN; HEALTHY CONTROLS; HEMOSIDERIN; IRON OVERLOADS; MANGANESE CHLORIDE; QUANTIFICATION; RELAXATION RATES; SOLUBLE FRACTION;

IRON OXIDES;

AGAROSE; FERRITIN; HEMOSIDERIN; IRON; IRON OXIDE; MANGANESE CHLORIDE; BIOLOGICAL MARKER;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEASIBILITY STUDY; HUMAN; IN VITRO STUDY; IRON OVERLOAD; IRON STORAGE; MONITORING; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; TISSUE PRESERVATION; ADOLESCENT; ADULT; BETA THALASSEMIA; COMPUTER ASSISTED DIAGNOSIS; FEMALE; HISTOLOGY; IMAGE ENHANCEMENT; LIVER; MALE; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

ADOLESCENT; ADULT; BETA-THALASSEMIA; BIOLOGICAL MARKERS; FEMALE; FERRITINS; HEMOSIDERIN; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LIVER; MAGNETIC RESONANCE IMAGING; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 77955290109     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22273     Document Type: Article

References (36)

1. Batts KP. Iron overload syndromes and the liver. Mod Pathol 2007; 20:S31-39. (Pubitemid 46733661)
2. Porter JB. Concepts and goals in the management of transfusional iron overload. Am J Hematol 2007;82:1136-1139. (Pubitemid 350221244)
3. Angelucci E, Brittenham GM, McLaren CE, Ripalti M, Baronciani D, Giardini C, Galimberti M, Polchi P, Lucarelli G. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med 2000;343:327-331. (Pubitemid 30616698)
4. Jensen PD. Evaluation of iron overload. Br J Haematol 2004;124: 697-711.
5. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1996; 1275:161-203. (Pubitemid 26248989)
6. Le Lan C, Loréal O, Cohen T, Ropert M, Glickstein H, Pouchard M, Deugnier Y, Le Treut A, Breuer W, Cabantchik ZI, Brissot P. Association between hepatic damage, iron overload and incidence of redoxactive iron in the plasma. Blood 2005;105:4527-4531.
7. Bou-Abdallah F, Zhao G, Mayne HR, Arosio P, Chasteen ND. Origin of the unusual kinetics of iron deposition in human H-chain ferritin. J Am Chem Soc 2005;127:3885-3893. (Pubitemid 40411430)
8. Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001;22:2171-2179. (Pubitemid 33139463)
9. Gandon Y, Olivié D, Guyader D, Aubé C, Oberti F, Sebille V, Deugnier Y. Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004;363:357-362. (Pubitemid 38169542)
10. St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005;105:855-861. (Pubitemid 40070775)
11. Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD. MRI R2 and R2*mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005;106:1460-1465. (Pubitemid 41129616)
12. Alustiza JM, Castiella A, De Juan MD, Emparanza JI, Artetxe J, Uranga M. Iron overload in the liver diagnostic and quantification. Eur J Radiol 2007;61:499-506.
13. Wood JC, Ghugre N. Magnetic resonance imaging assessment of excess iron in thalassemia, sickle cell disease and other iron overload diseases. Hemoglobin 2008;32:85-96. (Pubitemid 351264532)
14. Jensen JH, Chandra R. Theory of nonexponential NMR signal decay in liver with iron overload or superparamagnetic iron oxide particles. Magn Reson Med 2002;47:1131-1138. (Pubitemid 34587404)
15. Tang H, Jensen JH, Sheth S, Swaminathan S, Azabagic A, Tosti C, Brittenham GM, Brown TR. MR measurement of ferritin and hemosiderin iron in patients with iron overload. Proc Int Soc Magn Reson Med 2005;13:1880.
16. Sheth S, Tang H, Jensen JH, Altmann K, Prakash A, Printz BF, Hordof AJ, Tosti CL, Azabagic A, Swaminathan S, Brown TR, Olivieri NF, Brittenham GM. Methods for noninvasive measurement of tissue iron in Cooley's anemia. Ann N Y Acad Sci 2005;1054:358-372. (Pubitemid 43031043)
17. Tosti CL, Tang H, Jensen JH, Sheth S, Swaminathan SV, Hultman K, Azabagic A, Altmann K, Prakash A, Printz BF, Brown AL, Hordof AJ, Olivieri NF, Brittenham GM, Brown TR. MR estimation of myocardial ferritin iron and hemosiderin iron in thalassemia major. Proc Int Soc Magn Reson Med 2006;14:1201.
18. Thomsen C, Wiggers P, Ring-Larsen H, Christiansen E, Dalhoj J, Henriksen O, Christoffersen P. Identification of patients with hereditary haemochromatosis by magnetic resonance imaging and spectroscopic relaxation time measurements. Magn Reson Imaging 1992;10:867-879. (Pubitemid 23082019)
19. Bulte JW, Miller GF, Vymazal J, Brooks RA, Frank JA. Hepatic hemosiderosis in non-human primates: quantification of liver iron using different field strengths. Magn Reson Med 1997;37:530-536. (Pubitemid 27146831)
20. Ghugre NR, Coates TD, Nelson MD, Wood JC. Mechanisms of tissueiron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med 2005;54:1185-1193. (Pubitemid 41567198)
21. Ulmer JL, Mathews VP, Hamilton CA, Elster AD, Moran PR. Magnetization transfer or spin-lock? An investigation of off-resonance saturation pulse imaging with varying frequency offsets. AJNR Am J Neuroradiol 1996;17:805-819. (Pubitemid 26149082)
22. Vymazal J, Zak O, Bulte JW, Aisen P, Brooks RA. T1 and T2 of ferritin solutions: effect of loading factor. Magn Reson Med 1996;36: 61-65. (Pubitemid 26196532)
23. Gossuin Y, Burtea C, Monseux A, Toubeau G, Roch A, Muller RN, Gillis P. Ferritin-induced relaxation in tissues: an in vitro study. J Magn Reson Imaging 2004;20:690-696. (Pubitemid 39313746)
24. Pell GS, Briellmann RS, Waites AB, Abbott DF, Lewis DP, Jackson GD. Optimized clinical T2 relaxometry with a standard CPMG sequence. J Magn Reson Imaging 2006;23:248-252. (Pubitemid 43191082)
25. Swaminathan SV, Tosti CL, Hultman K, Jensen JH, Nunez A, Wu EX, Sheth S, Brittenham GM, Brown TR. Validation of clinically useful fast, multi slice, multi echo T2 quantification sequence. Proc Int Soc Magn Reson Med 2007;15:39.
26. St Pierre TG, Clark PR, Chua-Anusorn W. Single spin-echo proton transverse relaxometry of iron-loaded liver. NMR Biomed 2004;17: 446-458. (Pubitemid 39549422)
27. Henkelman RM. Measurement of signal intensities in the presence of noise in MR images. Med Phys 1985;12:232-233. (Pubitemid 15089010)
28. McGibney G, Smith MR. An unbiased signal-to-noise ratio measure for magnetic resonance images. Med Phys 1993;20:1077-1078. (Pubitemid 23249853)
29. Sijbers J, den Dekker AJ, Van Audekerke J, Verhoye M, Van Dyck D. Estimation of the noise in magnitude MR images. Magn Reson Imaging 1998;16:87-90. (Pubitemid 28020809)
30. Koay CG, Basser PJ. Analytically exact correction scheme for signal extraction from noisy magnitude MR signals. J Magn Reson 2006;179: 317-322.
31. Press WH, Teukolsky SA, Vetterling WT, Flannery BP. Numerical recipes in C: the art of scientific computing. New York, NY: Cambridge University Press; 1992. 994 p.
32. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89:739-761. (Pubitemid 27121266)
33. Zuyderhoudt FM, Sindram JW, Marx JJ, Jorning GG, van Gool J. The amount of ferritin and hemosiderin in the livers of patients with iron-loading diseases. Hepatology 1983;3:232-235. (Pubitemid 13165375)
34. Kim D, Jensen JH, Wu EX, Sheth SS, Brittenham GM. Breathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liver. Magn Reson Med 2009;62:300-306.
35. Vymazal J, Urgosik D, Bulte JW. Differentiation between hemosiderin- and ferritin-bound brain iron using nuclear magnetic resonance and magnetic resonance imaging. Cell Mol Biol (Noisy-le-grand) 2000;46:835-842.
36. Brooks RA, Vymazal J, Goldfarb RB, Bulte JW, Aisen P. Relaxometry and magnetometry of ferritin. Magn Reson Med 1998;40: 227-235. (Pubitemid 28361525)