Mechanisms of tissue-iron relaxivity: Nuclear magnetic resonance studies of human liver biopsy specimens

Magnetic Resonance in Medicine

Volumn 54, Issue 5, 2005, Pages 1185-1193

  Ghugre, Nilesh R ^a,b   Coates, Thomas D ^a   Nelson, Marvin D ^b   Wood, John C ^a,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Iron overload; Liver; Magnetic susceptibility; Mathematical modeling; Relaxation

Indexed keywords

BIOPSY; IRON; LIVER; MAGNETIC SUSCEPTIBILITY; MAGNETISM; MATHEMATICAL MODELS; TISSUE;

CHEMICAL EXCHANGE; HUMAN LIVER BIOPSY; INVERSION RECOVERY; IRON OVERLOADS; NONEXPONENTIAL RELAXATION; NUCLEAR MAGNETIC RESONANCE STUDIES; PROTON RELAXATION; RELAXATION;

NUCLEAR MAGNETIC RESONANCE;

HEMOSIDERIN; IRON;

ANEMIA; ARTICLE; BLOOD TRANSFUSION; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HISTOLOGY; HUMAN; HUMAN TISSUE; IRON OVERLOAD; LIVER BIOPSY; LIVER LYSOSOME; MEASUREMENT; MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; QUANTITATIVE DIAGNOSIS; SPECTROMETER;

EID: 27644555993     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20697     Document Type: Article

References (37)

1. Gordeuk VR, Bacon BR, Brittenham GM. Iron overload: causes and consequences. Annu Rev Nutr 1987;7:485-508.
2. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89:739-761.
3. Janes CH, Lindor KD. Outcome of patients hospitalized for complications after outpatient liver biopsy. Ann Intern Med 1993;118:96-98.
4. Ambu R, Crisponi G, Sciot R, Van Eyken P, Parodo G, Iannelli S, Marongiu F, Silvagni R, Nurchi V, Costa V, et al. Uneven hepatic iron and phosphorus distribution in beta-thalassemia. J Hepatol 1995;23:544-549.
5. Villeneuve JP, Bilodeau M, Lepage R, Cote J, Lefebvre M. Variability in hepatic iron concentration measurement from needle-biopsy specimens. J Hepatol 1996;25:172-177.
6. Brittenham GM, Badman DG. Noninvasive measurement of iron: report of an NIDDK workshop. Blood 2003;101:15-19.
7. Stark DD, Moss AA, Goldberg HI. Nuclear magnetic resonance of the liver, spleen, and pancreas. Cardiovasc Intervent Radiol 1986;8:329-341.
8. Stark DD, Moseley ME, Bacon BR, Moss AA, Goldberg HI, Bass NM, James TL. Magnetic resonance imaging and spectroscopy of hepatic iron overload. Radiology 1985;154:137-142.
9. St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005;105:855-861.
10. Westwood MA, Anderson LJ, Firmin DN, Gatehouse PD, Lorenz CH, Wonke B, Pennell DJ. Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemia. J Magn Reson Imaging 2003;18:616-620.
11. Thomsen C, Wiggers P, Ring-Larsen H, Christiansen E, Dalhoj J, Henriksen O, Christoffersen P. Identification of patients with hereditary haemochromatosis by magnetic resonance imaging and spectroscopic relaxation time measurements. Magn Reson Imaging 1992;10:867-879.
12. Wang ZJ, Haselgrove JC, Martin MB, Hubbard AM, Li S, Loomes K, Moore JR, Zhao H, Cohen AR. Evaluation of iron overload by single voxel MRS measurement of liver T2. J Magn Reson Imaging 2002;15:395-400.
13. Bulte JW, Miller GF, Vymazal J, Brooks RA, Frank JA. Hepatic hemosiderosis in non-human primates: quantification of liver iron using different field strengths. Magn Reson Med 1997;37:530-536.
14. Brooks RA, Moiny F, Gillis P. On T2-shortening by weakly magnetized particles: the chemical exchange model. Magn Reson Med 2001;45:1014-1020.
15. Jensen JH, Chandra R. Theory of nonexponential NMR signal decay in liver with iron overload or superparamagnetic iron oxide particles. Magn Reson Med 2002;47:1131-1138.
16. Gillis P, Moiny F, Brooks RA. On T(2)-shortening by strongly magnetized spheres: a partial refocusing model. Magn Reson Med 2002;47:257-263.
17. Mouton P. Principles and practices of unbiased stereology: An introduction for bioscientists. Baltimore: Johns Hopkins University Press; 2002.
18. Coleman TF, Li YY. On the convergence of reflective newton methods for large-scale nonlinear minimization subject to bounds. Math Program 1994;67:189-224.
19. Coleman TF, Li YY. An interior trust region approach for nonlinear minimization subject to bounds. Siam J Optimiz 1996;6:418-445.
20. Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H. Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 1999;210:617-623.
21. Liu P, Henkelman M, Joshi J, Hardy P, Butany J, Iwanochko M, Clauberg M, Dhar M, Mai D, Waien S, Olivieri N. Quantification of cardiac and tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia-cardiac iron overload model. Can J Cardiol 1996; 12:155-164.
22. Colet JM, Pierart C, Seghi F, Gabric I, Muller RN. Intravascular and intracellular hepatic relaxivities of superparamagnetic particles: an isolated and perfused organ pharmacokinetics study. J Magn Reson 1998;134:199-205.
23. Rozenman Y, Zou X, Kantor H. Signal loss induced by superparamagnetic iron oxide particles in NMR spin-echo images: the role of diffusion. Magn Reson Med 1990;14:14-31.
24. Jensen JH, Chandra R. Strong field behavior of the NMR signal from magnetically heterogeneous tissues. Magn Reson Med 2000;43:226-236.
25. Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001;22:2171-2179.
26. Gandon Y, Olivie D, Guyader D, Aube C, Oberti F, Sebille V, Deugnier Y. Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004;363:357-362.
27. St Pierre TG, Clark PR, Chua-Anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R. Non-invasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005;105:855-861.
28. Majumdar S, Zoghbi S, Pope CF, Gore JC. Quantitation of MR relaxation effects of iron oxide particles in liver and spleen. Radiology 1988;169: 653-658.
29. Majumdar S, Zoghbi S, Pope CF, Gore JC. A quantitative study of relaxation rate enhancement produced by iron oxide particles in polyacrylamide gels and tissue. Magn Reson Med 1989;9:185-202.
30. Majumdar S, Gore JC. Effects of selective pulses on the measurement of T2 and apparent diffusion in multiecho MRI. Magn Reson Med 1987;4:120-128.
31. Majumdar S, Zoghbi SS, Gore JC. The influence of pulse sequence on the relaxation effects of superparamagnetic iron oxide contrast agents. Magn Reson Med 1989;10:289-301.
32. Brittenham GM, Farrell DE, Harris JW, Feldman ES, Danish EH, Muir WA, Tripp JH, Bellon EM. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982;307:1671-1675.
33. Wood JC, Fassler JD, Meade T. Mimicking liver iron overload using liposomal ferritin preparations. Magn Reson Med 2004;51:607-611.
34. Mavrogeni SI, Gotsis ED, Markussis V, Tsekos N, Politis C, Vretou E, Kermastinos D. T2 relaxation time study of iron overload in b-thalassemia. Magma 1998;6:7-12.
35. Papakonstantinou O, Kostaridou S, Maris T, Gouliamos A, Premetis E, Kouloulias V, Nakopoulou L, Kattamis C. Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements. J Pediatr Hematol Oncol 1999;21:142-148.
36. Voskaridou E, Douskou M, Terpos E, Papassotiriou I, Stamoulakatou A, Ourailidis A, Loutradi A, Loukopoulos D. Magnetic resonance imaging in the evaluation of iron overload in patients with beta thalassaemia and sickle cell disease. Br J Haematol 2004;126:736-742.
37. Thomsen C. Quantitative magnetic resonance methods for in vivo investigation of the human liver and spleen. Technical aspects and preliminary clinical results. Acta Radiol Suppl 1996;401:1-34.