Hepatic hemosiderosis in non-human primates: Quantification of liver iron using different field strengths

Magnetic Resonance in Medicine

Volumn 37, Issue 4, 1997, Pages 530-536

  Bulte, Jeff W M ^a   Miller, Georgina F ^b   Vymazal, Josef ^c   Brooks, Rodney A ^c   Frank, Joseph A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

hemosiderin; iron quantification; liver; marmoset; relaxometry

Indexed keywords

LIVER; MAGNETIC RESONANCE IMAGING; MAMMALS; TISSUE;

FIELD INDEPENDENTS; HEMOSIDERIN; HIGH FIELD STRENGTHS; INTRACELLULAR WATER; LINEAR DEPENDENCE; MARMOSET; PROTON RELAXATION; RELAXOMETRY;

IRON;

HEMOSIDERIN; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; HEMOSIDEROSIS; IRON STORAGE; LIVER BIOPSY; LIVER DISEASE; MARMOSET; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 0030911943     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910370409     Document Type: Article

References (53)

1. C. Q. Edwards, L. M. Griffen, D. Goldgar, C. Drummond, M. H. Skolnick, J. P. Kushner, Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N. Engl. J. Med. 318, 1355-1362 (1988).
2. M. Simon, M. Bourel, R. Fauchet, B. Genetet, Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut 5, 332-334 (1976).
3. J. N. Feder, A. Gnirke, W. Thomas, Z. Tsuchihashi, D. A. Ruddy, A. Busava, F, Dormishian, R. Domingo Jr., M. C. Ellis, A. Fullan, L. M. Hinton, N. L. Jones, B. E. Kimmel, G. S. Kronmal, P. Lauer, V. K. Lee, D. B. Loeb, F. A. Mapa, E. McClelland, N. C. Meyer, G. A. Mintier, N. Moeller, T. Moore, E. Morikang, C. E. Prass, L. Quintana, S. M. Starnes, R. G. Schatzman, K. J. Brunke, D. T. Drayna, N. J. Risch, B. R. Bacon, R. K. Wolff, A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet. 13, 399-407 (1996).
4. P. D. Phatak, J. D. Cappuccio, Management of hereditary hemochromatosis, Blood Rev. 8, 193-198 (1994).
5. R. W. G. Chapman, G. Williams, G. Bydder, R. Dick, S. Shorlock, L. Kreel, Computed tomography for determining liver iron content in primary haemochromatosis. Br. Med. J. 280, 440-442 (1980).
6. G. Williams, G. M. Bydder, L. Kreel, The validity and use of computed tomography attenuation values. Br. Med. Bull. 38, 279-287 (1980).
7. R. G. Sephton, The potential accuracy of dual-energy computed tomography for the determination of hepatic iron. Br. J. Radiol. 59, 351-353 (1986).
8. D. Vartsky, K. J. Ellis, D. M. Hull, S. H. Cohn, Nuclear resonant scattering of gamma rays - a now technique for in vivo measurement of body iron stores. Phys. Med. Biol. 24, 680-701 (1979).
9. S. H. Cohn, K. J. Ellis, D. Vartsky, L. Wielopolski, Applications of nuclear technologies for in vivo elemental analysis. Neurotoxicology 4, 34-47 (1983).
10. G. M. Brittenham, D. E. Farell, J. W. Harris, E. S. Feldman, E. H. Danish, W. A. Muir, J. H. Tripp, E. M. Bellon, Magnetic-susceptibility measurement of human iron stores. N. Engl. J. Med. 307, 1671-1675 (1982).
11. R. Fischer, R. Engelhardt, P. Nielsen, E. E. Gabbe, H. C. Heinrich, W. H. Schmiegel, D. Wurbs, in "Biomagnetism: Clinical Aspects" (M. Hoke, S.N. Erné, Y.C. Okada, G.L. Romani, Eds.), p. 585, Excerpta Medica, Amsterdam, 1992.
12. F. H. Doyle, J. M. Pennock, L. M. Banks, M. J. McDonnell, G. M. Bydder, R. E. Steiner, I. R. Young, G. J. Clarke, T. Pasmore, D. J. Gilderdale, Nuclear magnetic resonance imaging of the liver: initial experience. Am, J. Roentgenol. 138, 193-200 (1982).
13. V. M. Runge, J. A. Clayton, F. W. Smith, J. Hutchison, J. Mallard, C. L. Partain, A. E. James Jr., Nuclear magnetic resonance of iron and copper disease states. Am. J. Roentgenol. 141, 943-948 (1983).
14. G. P. Borkowsky, E. Buonocore, C. R. George, R. T. Go, P. B. O'Donovan, T. F. Meaney, Nuclear magnetic resonance (NMR) imaging in the evaluation of the liver: a preliminary experience. J. Comp. Assist. Tomogr. 7, 768-774 (1983).
15. D. D. Stark, N. M. Bass, A. A. Moss, B. R. Bacon, J. H. McKerrow, C. E. Cann, A. Brito, H. I. Goldberg, Nuclear magnetic resonance imaging of experimentally induced liver disease. Radiology 148, 743-751 (1983).
16. R. C. Brasch, G. E. Wesbey, C. A. Gooding, M. A. Koerper, Magnetic resonance imaging of transfusional hemosiderosis complicating thalassemia major. Radiology 150, 767-771 (1984).
17. D. D. Stark, M. E. Moseley, B. R. Bacon, A. A. Moss, H. I. Goldberg, N. M. Bass, T. L. James, Magnetic resonance imaging and spectroscopy of hepatic iron overload. Radiology 154, 137-142 (1985).
18. D. W. Brown, R. M. Henkelman, P. Y. Poon, M. M. Fisher, Nuclear magnetic resonance study of iron overload in liver tissue. Magn. Reson. Imaging 3, 275-282 (1985).
19. D. D. Stark, Hepatic iron overload: paramagnetic pathology. Radiology 179, 333-335 (1991).
20. D. G. Mitchell, D. D. Stark, in "Magnetic Resonance Imaging" (D.D. Stark, W.G. Bradley, Jr., Eds.), 2nd Ed., p. 1746, Mosby-Year Book, St. Louis, 1992.
21. G. Bartzokis, M. Aravagiri, W. H. Oldendorf, J. Mintz, S. R. Marder, Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores. Magn. Reson. Med. 29, 459-464 (1993).
22. B. R. Bacon, A. S. Tavill, G. M. Brittenham, C. H. Park, R. O. Recknagel, Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J. Clin. Invest. 71, 429-439 (1983).
23. I. Y. Kim, D. G. Mitchell, S. Vinitski, P. M. Consigny, H-W. L. Hann, M. D. Rifkin, R. Rubin. MR imaging of hepatic iron overload in rat. J. Magn. Reson. Imaging 3, 67-70 (1993).
24. G. W. Richter, Studies of iron overload. Rat liver siderosome Ferritin. Lab. Invest. 50, 28-35 (1984).
25. A. Longueville, R. R. Crichton, An animal model of iron overload and its application to study hepatic ferritin iron mobilization by chelators. Biochem. Pharmacol. 35, 3689-3678 (1986).
26. R. J. Ward, A. L. Florence, D. Baldwin, C. Abiaka, F. Roland, M. H. Ramsey, D. P. E. Dickson, T. J. Peters, and R. P. Crichton. Biochemical and biophysical investigations of the ferrocene-iron-loaded rat. An animal model of primary hemochromatosis. Eur. J. Biochem. 202, 405-410 (1991).
27. R. Engelhardt, J. H. Langkowski, R. Fischer, P. Nielsen, H. Kooijman, H. C. Heinrich, E. Bücheler, Liver iron quantification: studies in aqueous iron solutions, iron overloaded rats, and patients with hereditary hemochromatosis, Magn. Reson. Imaging 12, 999-1007 (1994).
28. D. T. Chalmers, L. B. Murgatroyd, P. F. Wadsworth, A survey of the pathology of marmosets (Callithrix jacchus) derived from a marmoset breeding unit. Lab. Animals 17, 270-279 (1983).
29. M. Brack, H. Rothe, Chronic tubulointerstitial nephritis and wasting disease in marmosets (Callithrix jacchus). Vet. Pathol. 18(Suppl. 6), 45-54 (1981).
30. G. F. Miller, D. E. Barnard, R. A. Woodward, B. M. Flynn, J. W. M. Bulte, Hepatic hemosiderosis in common marmosets, Callithrix jacchus: the effect of diet on incidence and severity. Lab. Animal Science, in press.
31. L. L. Stookey, Ferrozine - a new spectrophotometric reagent for iron. Anal. Chem. 42, 779-781 (1970).
32. R. G. Lee, "Diagnostic Liver Pathology." Mosby-Year Book, St. Louis, 1994.
33. G. M. Nichols, B. R. Bacon, Hereditary hemochromatosis: pathogenesis and clinical features of a common disease. Am. J. Gastroenterol. 84, 851-862 (1989).
34. M. L. Bassett, J. W. Halliday, L. W. Powell, Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 6, 24-29 (1986).
35. L. R. Weintraub, A. Goral, J. Grasso, C. Franzblau, A. Sullivan, S. Sullivan, Pathogenesis of hepatic fibrosis in experimental iron overload. Br. J. Haematol. 59, 321-331 (1985).
36. A. Blouin, R. P. Holender, E. R. Weibel, Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. J. Cell Biol. 72, 441-455 (1977).
37. C. Thomsen, P. Wiggers, H. Ring-Larsen, E. Christiansen, J. Dalh'afj, O. Henriksen, P. Christoffersen, Identification of patients with hereditary haemochromatosis by magnetic resonance imaging and spectroscopic relaxation time measurements. Magn. Reson. Imaging 10, 867-879 (1992).
38. J. Vymazal, R. A. Brooks, O. Zak, C. McRill, C. Shen, G. Di Chiro, T1 and T2 of ferritin at different field strengths: effect on MRI. Magn. Reson. Med. 27, 368-374 (1992).
39. J. Vymazal, O. Zak, J. W. M. Bulte, P. Aisen, R. A. Brooks, T1 and T2 of ferritin solutions: effect of loading factor. Magn. Reson. Med. 36, 61-65 (1996).
40. J. W. M. Bulte, J. Vymazal, R. A. Brooks, C. Pierpaoli, J. A. Frank, Frequency dependence of MR relaxation times. II. Iron oxides. J. Magn. Reson. Imaging 3, 641-648 (1993).
41. R. A. Brooks, J. Vymazal, J. W. M. Bulte, C. D. Baumgarner, V. A. Tran, Comparison of T2 relaxation in blood, brain, and ferritin. J. Magn. Reson. Imaging 5, 446-450 (1995).
42. J. Vymazal, R. A. Brooks, C. Baumgarner, V. Tran, D. Katz, J. W. M. Bulte, E. R. Bauminger, G. Di Chiro, The relation between brain iron and NMR relaxation times: an in vitro study. Magn. Reson. Med. 35, 56-61 (1996).
43. R. L. Wixom, L. Prutkin, H. N. Munro, Hemosiderin: nature, formation, and significance. Int. Rev. Exp. Pathol. 22, 193-225 (1980).
44. Z. Luz, S. Meiboom, Nuclear magnetic resonance study of the protolysis of trimethylammonium ion in aqueous solution-order of the reaction with respect to solvent. J. Chem. Phys. 39, 366-370 (1963).
45. K.R Thulborn, J. C. Waterton, P. M. Matthews, G. K. Radda, Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim. Biophys. Acta 714, 265-270 (1982).
46. J. M. Gomori, R. I. Grossman, C. Yu-Ip, T. Asakura, NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity. J. Comp. Assist. Tomogr. 11, 684-690 (1987).
47. J. P. Kaltwasser, R. Gottschalk, K. P. Schalk, W. Hartl, Non-invasive quantitation of liver iron-overload by magnetic resonance imaging. Br. J. Haematol. 74, 360-363 (1990).
48. J. M. Gomori, G. Horev, H. Tamary, J. Zandback, L. Kornreich, R. Zaizov, E. Freud, O. Krief, J. Ben-Meir, H. Rotem, M. Kuspet, P. Rosen, E. A. Rachmilewitz, E. Loewenthal, R. Gorodetsky, Hepatic iron overload: quantitative MR imaging. Radiology 179, 367-369 (1991).
49. Y. Gandon, D. Guyader, J. F. Heautot, M.-I. Reda, J. Yaouanq, T. Buhé, P, Brissot, M. Carsin, Y, Deugnier, Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. Radiology 193, 533-538 (1994).
50. R. M. Dixon, P. Styles, An assessment of spin-echo rotating-frame imaging for spatially localized determination of short T2 relaxation times in vivo. Magn. Reson. Med. 29, 110-112 (1993).
51. R. M. Dixon, P. Styles, F. N. Al-Refaie, G. J. Kemp, S. M. Donohue, B. Wonke, A. V. Hoffbrand, G. K. Radda, B. Rajagopalan, Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy. Hepatology 19, 904-910 (1994).
52. J. M. Gomori, R. I. Grossman, H. R. Drott, MR relaxation times and iron content of thalassemic spleens: an in vitro study, Am. J. Roentgenol. 150, 567-569 (1988).
53. F. Q. Ye, W. R. W. Martin, P. S. Allen, Estimation of the iron concentration in excised gray matter by means of proton relaxation measurements. Magn. Reson. Med. 35, 285-289 (1996).