메뉴 건너뛰기




Volumn 169, Issue 3, 2010, Pages 1337-1346

Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist

Author keywords

8 OH DPAT; Antipsychotic; Anxiolytic; Dopamine receptor; Glycogen; Serotonin receptor

Indexed keywords

8 [4 [(6 METHOXY 2,3 DIHYDRO[1,4]DIOXINO[2,3 B]PYRIDINE 3 YLMETHYL)AMINO]BUTYL] 8 AZA SPIRO[4.5]DECANE 7,9 DIONE; ALPHA 2 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; DOPAMINE 1 RECEPTOR; JB 788; METHAMPHETAMINE; MUSCARINIC RECEPTOR; SEROTONIN 1A AGONIST; UNCLASSIFIED DRUG;

EID: 77955282388     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.05.040     Document Type: Article
Times cited : (8)

References (54)
  • 1
    • 0035200432 scopus 로고    scopus 로고
    • Neuronal instability: implications for Rett's syndrome
    • Azmitia E.C. Neuronal instability: implications for Rett's syndrome. Brain Dev 2001, 23(Suppl 1):S1-S10.
    • (2001) Brain Dev , vol.23 , Issue.SUPPL 1
    • Azmitia, E.C.1
  • 2
    • 33846889762 scopus 로고    scopus 로고
    • [18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain
    • Aznavour N., Zimmer L. [18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain. Neuropharmacology 2007, 52:695-707.
    • (2007) Neuropharmacology , vol.52 , pp. 695-707
    • Aznavour, N.1    Zimmer, L.2
  • 3
    • 0037040499 scopus 로고    scopus 로고
    • In vivo and in vitro glycogenic effects of methionine sulfoximine are different in two inbred strains of mice
    • Bernard-Helary K., Ardourel M.Y., Hevor T., Cloix J.F. In vivo and in vitro glycogenic effects of methionine sulfoximine are different in two inbred strains of mice. Brain Res 2002, 929:147-155.
    • (2002) Brain Res , vol.929 , pp. 147-155
    • Bernard-Helary, K.1    Ardourel, M.Y.2    Hevor, T.3    Cloix, J.F.4
  • 4
    • 0037304917 scopus 로고    scopus 로고
    • Is there a role for 5-HT1A agonists in the treatment of depression?
    • Blier P., Ward N.M. Is there a role for 5-HT1A agonists in the treatment of depression?. Biol Psychiatry 2003, 53:193-203.
    • (2003) Biol Psychiatry , vol.53 , pp. 193-203
    • Blier, P.1    Ward, N.M.2
  • 5
    • 0029064303 scopus 로고
    • The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors
    • Bonhaus D.W., Bach C., DeSouza A., Salazar F.H., Matsuoka B.D., Zuppan P., Chan H.W., Eglen R.M. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br J Pharmacol 1995, 115:622-628.
    • (1995) Br J Pharmacol , vol.115 , pp. 622-628
    • Bonhaus, D.W.1    Bach, C.2    DeSouza, A.3    Salazar, F.H.4    Matsuoka, B.D.5    Zuppan, P.6    Chan, H.W.7    Eglen, R.M.8
  • 6
    • 0031057229 scopus 로고    scopus 로고
    • Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze
    • Cao B.J., Rodgers R.J. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl) 1997, 129:365-371.
    • (1997) Psychopharmacology (Berl) , vol.129 , pp. 365-371
    • Cao, B.J.1    Rodgers, R.J.2
  • 7
    • 0025944364 scopus 로고
    • Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain-a combined in situ hybridisation/in vitro receptor autoradiographic study
    • Chalmers D.T., Watson S.J. Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain-a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res 1991, 561:51-60.
    • (1991) Brain Res , vol.561 , pp. 51-60
    • Chalmers, D.T.1    Watson, S.J.2
  • 8
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
    • Cheng Y., Prusoff W.H. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 1973, 22:3099-3108.
    • (1973) Biochem Pharmacol , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 9
    • 13444291123 scopus 로고    scopus 로고
    • Role of GABA-ergic and serotonergic systems in the anxiolytic-like mechanism of action of a 5-HT-moduline antagonist in the mouse elevated plus maze
    • Clenet F., Hascoet M., Fillion G., Galons H., Bourin M. Role of GABA-ergic and serotonergic systems in the anxiolytic-like mechanism of action of a 5-HT-moduline antagonist in the mouse elevated plus maze. Behav Brain Res 2005, 158:339-348.
    • (2005) Behav Brain Res , vol.158 , pp. 339-348
    • Clenet, F.1    Hascoet, M.2    Fillion, G.3    Galons, H.4    Bourin, M.5
  • 10
    • 0035861850 scopus 로고    scopus 로고
    • Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells
    • Cosi C., Koek W. Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells. Eur J Pharmacol 2001, 433:55-62.
    • (2001) Eur J Pharmacol , vol.433 , pp. 55-62
    • Cosi, C.1    Koek, W.2
  • 11
    • 33847354629 scopus 로고    scopus 로고
    • Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities
    • Cuisiat S., Bourdiol N., Lacharme V., Newman-Tancredi A., Colpaert F., Vacher B. Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities. J Med Chem 2007, 50:865-876.
    • (2007) J Med Chem , vol.50 , pp. 865-876
    • Cuisiat, S.1    Bourdiol, N.2    Lacharme, V.3    Newman-Tancredi, A.4    Colpaert, F.5    Vacher, B.6
  • 12
    • 52949147789 scopus 로고    scopus 로고
    • 5-HT1 receptor augmentation strategies as enhanced efficacy: therapeutics for psychiatric disorders
    • Dawson L.A., Bromidge S.M. 5-HT1 receptor augmentation strategies as enhanced efficacy: therapeutics for psychiatric disorders. Curr Top Med Chem 2008, 8:1008-1023.
    • (2008) Curr Top Med Chem , vol.8 , pp. 1008-1023
    • Dawson, L.A.1    Bromidge, S.M.2
  • 13
    • 0030952588 scopus 로고    scopus 로고
    • Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe
    • Dong J., de Montigny C., Blier P. Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. Naunyn Schmiedebergs Arch Pharmacol 1997, 356:303-311.
    • (1997) Naunyn Schmiedebergs Arch Pharmacol , vol.356 , pp. 303-311
    • Dong, J.1    de Montigny, C.2    Blier, P.3
  • 14
    • 65549122835 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressant response: an update
    • Drago A., De Ronchi D., Serretti A. Pharmacogenetics of antidepressant response: an update. Hum Genomics 2009, 3:257-274.
    • (2009) Hum Genomics , vol.3 , pp. 257-274
    • Drago, A.1    De Ronchi, D.2    Serretti, A.3
  • 15
    • 0018875386 scopus 로고
    • Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents
    • Folbergrova J. Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. Neurosci Lett 1980, 16:291-296.
    • (1980) Neurosci Lett , vol.16 , pp. 291-296
    • Folbergrova, J.1
  • 17
    • 0026610461 scopus 로고
    • Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat
    • Grasby P.M., Sharp T., Allen T., Kelly P.A., Grahame-Smith D.G. Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat. Psychopharmacology (Berl) 1992, 106:97-101.
    • (1992) Psychopharmacology (Berl) , vol.106 , pp. 97-101
    • Grasby, P.M.1    Sharp, T.2    Allen, T.3    Kelly, P.A.4    Grahame-Smith, D.G.5
  • 18
    • 33748060985 scopus 로고    scopus 로고
    • Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder
    • Gray L., Scarr E., Dean B. Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder. Psychiatry Res 2006, 143:111-120.
    • (2006) Psychiatry Res , vol.143 , pp. 111-120
    • Gray, L.1    Scarr, E.2    Dean, B.3
  • 19
    • 0018332473 scopus 로고
    • Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors
    • Greengrass P., Bremner R. Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors. Eur J Pharmacol 1979, 55:323-326.
    • (1979) Eur J Pharmacol , vol.55 , pp. 323-326
    • Greengrass, P.1    Bremner, R.2
  • 20
    • 0030912961 scopus 로고    scopus 로고
    • Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors
    • Hall D.A., Strange P.G. Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors. Br J Pharmacol 1997, 121:731-736.
    • (1997) Br J Pharmacol , vol.121 , pp. 731-736
    • Hall, D.A.1    Strange, P.G.2
  • 21
    • 0037469488 scopus 로고    scopus 로고
    • Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration
    • Hensler J.G. Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. Life Sci 2003, 72:1665-1682.
    • (2003) Life Sci , vol.72 , pp. 1665-1682
    • Hensler, J.G.1
  • 22
    • 0022877263 scopus 로고
    • Glycogen synthesis and immunocytochemical study of fructose-1,6-biphosphatase in methionine sulfoximine epileptogenic rodent brain
    • Hevor T.K., Delorme P., Beauvillain J.C. Glycogen synthesis and immunocytochemical study of fructose-1,6-biphosphatase in methionine sulfoximine epileptogenic rodent brain. J Cereb Blood Flow Metab 1986, 6:292-297.
    • (1986) J Cereb Blood Flow Metab , vol.6 , pp. 292-297
    • Hevor, T.K.1    Delorme, P.2    Beauvillain, J.C.3
  • 24
    • 0022273541 scopus 로고
    • Characterization of the 5-HT1B recognition site in rat brain: binding studies with (-)[125I]iodocyanopindolol
    • Hoyer D., Engel G., Kalkman H.O. Characterization of the 5-HT1B recognition site in rat brain: binding studies with (-)[125I]iodocyanopindolol. Eur J Pharmacol 1985, 118:1-12.
    • (1985) Eur J Pharmacol , vol.118 , pp. 1-12
    • Hoyer, D.1    Engel, G.2    Kalkman, H.O.3
  • 25
    • 0014783247 scopus 로고
    • Physiological and drug-induced changes in the glycogen content of mouse brain
    • Hutchins D.A., Rogers K.J. Physiological and drug-induced changes in the glycogen content of mouse brain. Br J Pharmacol 1970, 39:9-25.
    • (1970) Br J Pharmacol , vol.39 , pp. 9-25
    • Hutchins, D.A.1    Rogers, K.J.2
  • 26
    • 0015147024 scopus 로고
    • Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine
    • Hutchins D.A., Rogers K.J. Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine. Br J Pharmacol 1971, 43:504-513.
    • (1971) Br J Pharmacol , vol.43 , pp. 504-513
    • Hutchins, D.A.1    Rogers, K.J.2
  • 27
    • 0015619776 scopus 로고
    • Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine-induced glycogenolysis in the brain
    • Hutchins D.A., Rogers K.J. Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine-induced glycogenolysis in the brain. Br J Pharmacol 1973, 48:19-29.
    • (1973) Br J Pharmacol , vol.48 , pp. 19-29
    • Hutchins, D.A.1    Rogers, K.J.2
  • 28
    • 0037177358 scopus 로고    scopus 로고
    • The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
    • Jordan S., Koprivica V., Chen R., Tottori K., Kikuchi T., Altar C.A. The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor. Eur J Pharmacol 2002, 441:137-140.
    • (2002) Eur J Pharmacol , vol.441 , pp. 137-140
    • Jordan, S.1    Koprivica, V.2    Chen, R.3    Tottori, K.4    Kikuchi, T.5    Altar, C.A.6
  • 29
    • 2442702676 scopus 로고    scopus 로고
    • Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers
    • Joseph S.S., Lynham J.A., Colledge W.H., Kaumann A.J. Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. Naunyn Schmiedebergs Arch Pharmacol 2004, 369:525-532.
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 525-532
    • Joseph, S.S.1    Lynham, J.A.2    Colledge, W.H.3    Kaumann, A.J.4
  • 30
    • 59149099752 scopus 로고    scopus 로고
    • Current considerations in the treatment of generalized anxiety disorder
    • Katzman M.A. Current considerations in the treatment of generalized anxiety disorder. CNS Drugs 2009, 23:103-120.
    • (2009) CNS Drugs , vol.23 , pp. 103-120
    • Katzman, M.A.1
  • 31
    • 34548413531 scopus 로고    scopus 로고
    • PET tracers for 5-HT(1A) receptors and uses thereof
    • Kumar J.S., Mann J.J. PET tracers for 5-HT(1A) receptors and uses thereof. Drug Discov Today 2007, 12:748-756.
    • (2007) Drug Discov Today , vol.12 , pp. 748-756
    • Kumar, J.S.1    Mann, J.J.2
  • 32
    • 0033827305 scopus 로고    scopus 로고
    • Central 5-HT(1A) receptors: regional distribution and functional characteristics
    • Lanfumey L., Hamon M. Central 5-HT(1A) receptors: regional distribution and functional characteristics. Nucl Med Biol 2000, 27:429-435.
    • (2000) Nucl Med Biol , vol.27 , pp. 429-435
    • Lanfumey, L.1    Hamon, M.2
  • 34
    • 0027336835 scopus 로고
    • Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation
    • Lazareno S., Birdsall N.J. Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation. Trends Pharmacol Sci 1993, 14:237-239.
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 237-239
    • Lazareno, S.1    Birdsall, N.J.2
  • 35
    • 0034694934 scopus 로고    scopus 로고
    • Balance control and posture differences in the anxious BALB/cByJ mice compared to the non anxious C57BL/6J mice
    • Lepicard E.M., Venault P., Perez-Diaz F., Joubert C., Berthoz A., Chapouthier G. Balance control and posture differences in the anxious BALB/cByJ mice compared to the non anxious C57BL/6J mice. Behav Brain Res 2000, 117:185-195.
    • (2000) Behav Brain Res , vol.117 , pp. 185-195
    • Lepicard, E.M.1    Venault, P.2    Perez-Diaz, F.3    Joubert, C.4    Berthoz, A.5    Chapouthier, G.6
  • 36
    • 0037163005 scopus 로고    scopus 로고
    • The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation
    • Levin M.C., Marullo S., Muntaner O., Andersson B., Magnusson Y. The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation. J Biol Chem 2002, 277:30429-30435.
    • (2002) J Biol Chem , vol.277 , pp. 30429-30435
    • Levin, M.C.1    Marullo, S.2    Muntaner, O.3    Andersson, B.4    Magnusson, Y.5
  • 39
    • 0033696731 scopus 로고    scopus 로고
    • Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors
    • Millan M.J. Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors. J Pharmacol Exp Ther 2000, 295:853-861.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 853-861
    • Millan, M.J.1
  • 42
  • 44
    • 0015505764 scopus 로고
    • Barbiturate-induced glycogen accumulation in brain. An electron microscopic study
    • Phelps C.H. Barbiturate-induced glycogen accumulation in brain. An electron microscopic study. Brain Res 1972, 39:225-234.
    • (1972) Brain Res , vol.39 , pp. 225-234
    • Phelps, C.H.1
  • 45
    • 0025332575 scopus 로고
    • Rat hippocampal muscarinic autoreceptors are similar to the M2 (cardiac) subtype: comparison with hippocampal M1, atrial M2 and ileal M3 receptors
    • Richards M.H. Rat hippocampal muscarinic autoreceptors are similar to the M2 (cardiac) subtype: comparison with hippocampal M1, atrial M2 and ileal M3 receptors. Br J Pharmacol 1990, 99:753-761.
    • (1990) Br J Pharmacol , vol.99 , pp. 753-761
    • Richards, M.H.1
  • 47
    • 0033976134 scopus 로고    scopus 로고
    • Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis
    • Silva R.C., Brandao M.L. Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. Pharmacol Biochem Behav 2000, 65:209-216.
    • (2000) Pharmacol Biochem Behav , vol.65 , pp. 209-216
    • Silva, R.C.1    Brandao, M.L.2
  • 48
    • 0032845187 scopus 로고    scopus 로고
    • Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation
    • Sprouse J.S., Reynolds L.S., Braselton J.P., Rollema H., Zorn S.H. Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology 1999, 21:622-631.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 622-631
    • Sprouse, J.S.1    Reynolds, L.S.2    Braselton, J.P.3    Rollema, H.4    Zorn, S.H.5
  • 49
    • 61749086565 scopus 로고    scopus 로고
    • Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics
    • Sumiyoshi T., Bubenikova-Valesova V., Horacek J., Bert B. Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics. Adv Ther 2008, 25:1037-1056.
    • (2008) Adv Ther , vol.25 , pp. 1037-1056
    • Sumiyoshi, T.1    Bubenikova-Valesova, V.2    Horacek, J.3    Bert, B.4
  • 50
    • 34548189417 scopus 로고    scopus 로고
    • Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study
    • Sumiyoshi T., Park S., Jayathilake K., Roy A., Ertugrul A., Meltzer H.Y. Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study. Schizophr Res 2007, 95:158-168.
    • (2007) Schizophr Res , vol.95 , pp. 158-168
    • Sumiyoshi, T.1    Park, S.2    Jayathilake, K.3    Roy, A.4    Ertugrul, A.5    Meltzer, H.Y.6
  • 51
    • 0015950112 scopus 로고
    • Reserpine-induced glycogen accumulation in the epithelial cells of the mouse choroid plexus
    • Suzuki Y., Ito T. Reserpine-induced glycogen accumulation in the epithelial cells of the mouse choroid plexus. Brain Res 1974, 70:113-122.
    • (1974) Brain Res , vol.70 , pp. 113-122
    • Suzuki, Y.1    Ito, T.2
  • 52
    • 0026001906 scopus 로고
    • Rat spinal cord alpha 2-adrenoceptors are of the alpha 2A-subtype: comparison with alpha 2A- and alpha 2B-adrenoceptors in rat spleen, cerebral cortex and kidney using 3H-RX821002 ligand binding
    • Uhlen S., Wikberg J.E. Rat spinal cord alpha 2-adrenoceptors are of the alpha 2A-subtype: comparison with alpha 2A- and alpha 2B-adrenoceptors in rat spleen, cerebral cortex and kidney using 3H-RX821002 ligand binding. Pharmacol Toxicol 1991, 69:341-350.
    • (1991) Pharmacol Toxicol , vol.69 , pp. 341-350
    • Uhlen, S.1    Wikberg, J.E.2
  • 53
    • 67650081409 scopus 로고    scopus 로고
    • 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity
    • Zhang J., Zhang H., Cai W., Yu L., Zhen X., Zhang A. (2009)'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. Bioorg Med Chem 2009, 17:4873-4880.
    • (2009) Bioorg Med Chem , vol.17 , pp. 4873-4880
    • Zhang, J.1    Zhang, H.2    Cai, W.3    Yu, L.4    Zhen, X.5    Zhang, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.