Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder

Psychiatry Research

Volumn 143, Issue 2-3, 2006, Pages 111-120

  Gray, Laura ^a,b   Scarr, Elizabeth ^a,b   Dean, Brian ^a,b,c  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

8 OH DPAT; Cortex; Gender; GTP S; Psychosis

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); SEROTONIN 1A RECEPTOR;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; BRAIN CORTEX; BRAIN REGION; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DISSOCIATION; FEMALE; HUMAN; LIGAND BINDING; MALE; NEUROPATHOLOGY; PARIETAL LOBE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY; SCHIZOPHRENIA; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM; SEX DIFFERENCE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADULT; AGED; BIPOLAR DISORDER; BRAIN MAPPING; FEMALE; FRONTAL LOBE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MALE; MIDDLE AGED; PARIETAL LOBE; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; SCHIZOPHRENIA; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION;

EID: 33748060985     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2005.09.010     Document Type: Article

References (50)

1. Aleman A., Kahn R.S., and Selten J.P. Sex differences in the risk of schizophrenia: evidence from meta-analysis. Archives of General Psychiatry 60 (2003) 565-571
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Press, Washington, DC
3. Arango V., Underwood M.D., Gubbi A.V., and Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research 688 (1995) 121-3013
4. Avissar S., Roitman G., and Schreiber G. Differential effects of the antipsychotics haloperidol and clozapine on G protein measures in mononuclear leukocytes of patients with schizophrenia. Cellular and Molecular Neurobiology 21 (2001) 799-811
5. 3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia. Neurochemistry International 30 (1997) 565-574
6. Burt V.K., and Rasgon N. Special considerations in treating bipolar disorder in women. Bipolar Disorders 6 (2004) 2-13
7. Carrasco G.A., Barker S.A., Zhang Y., Damjanoska K.J., Sullivan N.R., Garcia F., D'Souza D.N., Muma N.A., and van De Kar L.D. Estrogen treatment increases the levels of regulator of G protein signaling-Z1 in the hypothalamic paraventricular nucleus: possible role in desensitization of 5-hydroxytryptamine1A receptors. Neuroscience 127 (2004) 261-267
8. Chou Y.H., Halldin C., and Farde L. Occupancy of 5-HT1A receptors by clozapine in the primate brain: a PET study. Psychopharmacology (Berlin) 166 (2003) 234-240
9. Cruz D.A., Eggan S.M., Azmitia E.C., and Lewis D.A. Serotonin 1A receptors at the axon initial segment of prefrontal pyramidal neurons in schizophrenia. American Journal of Psychiatry 161 (2004) 739-742
10. Dean B., Tomaskovic-Crook E., Opeskin K., Keks N., and Copolov D. No change in the density of the serotonin 1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia. Neurochemistry International 34 (1999) 109-115
11. Dean B., Scarr E., Pavey G., and Copolov D. Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder. Journal of Affective Disorders 75 (2003) 65-69
12. Dowlatshahi D., MacQueen G.M., Wang J.F., Reiach J.S., and Young L.T. G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. Journal of Neurochemistry 73 (1999) 1121-1126
13. Emamghoreishi M., Li P.P., Schlichter L., Parikh S.V., Cooke R., and Warsh J.J. Associated disturbances in calcium homeostasis and G protein-mediated cAMP signaling in bipolar I disorder. Biological Psychiatry 48 (2000) 665-673
14. Foster P. Neuroleptic equivalence. Pharmaceutical Journal 243 (1999) 431-432
15. Friedman E., and Wang H.Y. Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. Journal of Neurochemistry 67 (1996) 1145-1152
16. Gundlah C., Alves S.E., Clark J.A., Pai L.Y., Schaeffer J.M., and Rohrer S.P. Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe. Biological Psychiatry 57 (2005) 938-942
17. Gurevich E.V., and Joyce J.N. Alterations in the cortical serotonergic system in schizophrenia: a postmortem study. Biological Psychiatry 42 (1997) 529-545
18. Hashimoto T., Nishino N., Nakai H., and Tanaka C. Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sciences 48 (1991) 355-363
19. Heninger G.R. Serotonin, sex, and psychiatric illness. Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 4823-4824
20. Jakobsen S.N., and Wiborg O. Selective effects of long-term lithium and carbamazepine administration on G-protein subunit expression in rat brain. Brain Research 780 (1998) 46-55
21. Jope R.S., Song L., Grimes C.A., Pacheco M.A., Dilley G.E., Li X., Meltzer H.Y., Overholser J.C., and Stockmeier C.A. Selective increases in phosphoinositide signaling activity and G protein levels in postmortem brain from subjects with schizophrenia or alcohol dependence. Journal of Neurochemistry 70 (1998) 763-771
22. Jordan S., Koprivica V., Chen R., Tottori K., Kikuchi T., and Altar C.A. The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor. European Journal of Pharmacology 441 (2002) 137-140
23. Joyce J.N., Shane A., Lexow N., Winokur A., Casanova M.F., and Kleinman J.E. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8 (1993) 315-336
24. Kaplan G.B., Leite-Morris K.A., and Keith D.J. Differential effects of treatment with typical and atypical antipsychotic drugs on adenylyl cyclase and G proteins. Neuroscience Letters 273 (1999) 147-150
25. Karege F., Golaz J., Schwald M., and Malafosse A. Lithium and haloperidol treatments differently affect the mononuclear leukocyte Gαs protein levels in bipolar affective disorder. Neuropsychobiology 39 (1999) 181-186
26. Kessing L.V. Gender differences in the phenomenology of bipolar disorder. Bipolar Disorders 6 (2004) 421-425
27. Le Saux M., and Di Paolo T. Changes in 5-HT1A receptor binding and G-protein activation in the rat brain after estrogen treatment: comparison with tamoxifen and raloxifene. Journal of Psychiatry & Neuroscience 30 (2005) 110-117
28. Lesch K.P. Hallucinations: psychopathology meets functional genomics. Molecular Psychiatry 3 (1998) 278-281
29. Lopez-Figueroa A.L., Norton C.S., Lopez-Figueroa M.O., Armellini-Dodel D., Burke S., Akil H., Lopez J.F., and Watson S.J. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biological Psychiatry 55 (2004) 225-233
30. Manji H.K., Chen G., Shimon H., Hsiao J.K., Potter W.Z., and Belmaker R.H. Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment. Archives of General Psychiatry 52 (1995) 135-144
31. iα1. Archives of Biochemistry and Biophysics 388 (2001) 7-12
32. 1A receptor function. Neuroendocrinology 73 (2001) 166-174
33. 35S]GTPγS binding study. European Journal of Pharmacology 355 (1998) 245-256
34. Palego L., Marazziti D., Rossi A., Giannaccini G., Naccarato A.G., Lucacchini A., and Cassano G.B. Apparent absence of aging and gender effects on serotonin 1A receptors in human neocortex and hippocampus. Brain Research 758 (1997) 26-32
35. Parsey R.V., Oquendo M.A., Simpson N.R., Ogden R.T., Van Heertum R., Arango V., and Mann J.J. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Research 954 (2002) 173-182
36. Rodriguez-Puertas R., Gonzalez-Maeso J., Meana J.J., and Pazos A. Autoradiography of receptor-activated G-proteins in post mortem human brain. Neuroscience 96 (2000) 169-180
37. Roth B.L., Sheffler D.J., and Kroeze W.K. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Reviews Drug Discovery 3 (2004) 353-359
38. Sanchez R.L., Reddy A.P., Centeno M.L., Henderson J.A., and Bethea C.L. A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques. Brain Research. Molecular Brain Research 135 (2005) 194-203
39. Schreiber G., and Avissar S. Application of G-proteins in the molecular diagnosis of psychiatric disorders. Expert Reviews in Molecular Diagnosis 3 (2003) 69-80
40. Seeman M.V. Women and schizophrenia. Medscape Womens Health 5 (2000) 2
41. Serres F., Muma N.A., Raap D.K., Garcia F., Battaglia G., and Van de Kar L.D. Coadministration of 5-hydroxytryptamine 1A antagonist WAY-100635 prevents fluoxetine-induced desensitization of postsynaptic 5-hydroxytryptamine 1A receptors in hypothalamus. Journal of Pharmacology and Experimental Therapeutics 294 (2000) 296-301
42. 3H]8-OH-DPAT reveals increases in 5-HT(1A) receptors in ventral prefrontal cortex in schizophrenia. Biological Psychiatry 39 (1996) 919-928
43. Slater P., Doyle C.A., and Deakin J.F. Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates. Journal of Neural Transmission 105 (1998) 305-315
44. Smith L.J., Henderson J.A., Abell C.W., and Bethea C.L. Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques. Neuropsychopharmacology 29 (2004) 2035-2045
45. 35S]GTPγS. Brain Research Reviews 38 (2001) 149-164
46. i2-subunit mRNA expression in bipolar affective disorder. Molecular Psychiatry 3 (1998) 512-520
47. Tauscher J., Kapur S., Verhoeff N.P., Hussey D.F., Daskalakis Z.J., Tauscher-Wisniewski S., Wilson A.A., Houle S., Kasper S., and Zipursky R.B. Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635. Archives of General Psychiatry 59 (2002) 514-520
48. Wang H.Y., and Friedman E. Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes. Neuropharmacology 38 (1999) 403-414
49. Willmroth F., Spleiss O., Wiesmann K., Moser D., Atmanspacher R., and van Calker D. Expression of G-proteins and regulators of G-protein signalling in neutrophils of patients with bipolar disorder: effects of mood stabilizers. Bipolar Disorders 4 Suppl 1 (2002) 75-76
50. Yang C.-Q., Kitamura N., Nishino N., Shirakawa O., and Nakai H. Isotype-specific G protein abnormalities in the left superior temporal cortex and limbic structures of patients with chronic schizophrenia. Biological Psychiatry 43 (1998) 12-19