Role of H2O2 on the kinetics of low-affinity high-capacity Na+-dependent alanine transport in SHR proximal tubular epithelial cells

Biochemical and Biophysical Research Communications

Volumn 398, Issue 3, 2010, Pages 553-558

  Pinto, Vanda ^a   Pinho, Maria João ^a   Jose, Pedro A ^b   Soares da Silva, Patrício ^a  

^a University of Porto   (Portugal)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

ASCT2; H2O2 production; SHR; Sodium binding

Indexed keywords

ALANINE; AMINO ACID TRANSPORTER; APOCYNIN; CHOLINE; HYDROGEN PEROXIDE; PROTEIN ASCT2; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL IMMORTALIZATION; CONTROLLED STUDY; CULTURE MEDIUM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ALANINE; AMINO ACID TRANSPORT SYSTEM ASC; ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; HYDROGEN PEROXIDE; KIDNEY TUBULES, PROXIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SODIUM;

RATTUS;

EID: 77955274923     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.06.117     Document Type: Article

References (35)

1. +-dependent neutral amino acid transporter (B0AT2). Biochem. J. 2006, 393:421-430.
2. (+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein. Am. J. Physiol. Cell Physiol. 2001, 281:C963-C971.
3. Kanai Y., Hediger M.A. The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Eur. J. Pharmacol. 2003, 479:237-247.
4. +-dependent neutral amino acid transporter. J. Biol. Chem. 1996, 271:14883-14890.
5. Bode B.P. Recent molecular advances in mammalian glutamine transport. J. Nutr. 2001, 131:2475S-2485S.
6. +-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 293:R538-R547.
7. Hediger M.A. Glutamate transporters in kidney and brain. Am. J. Physiol. 1999, 277:F487-F492.
8. Agostinho P., Duarte C.B., Oliveira C.R. Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: effect of antioxidants. FASEB J. 1997, 11:154-163.
9. + dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress. Brain Res. 2001, 922:21-29.
10. +-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005, 579:2499-2506.
11. Pinto V., Pinho M.J., Hopfer U., Jose P.A., Soares-da-Silva P. Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. Mol. Cell Biochem. 2008, 310:191-201.
12. -/HCO3- exchanger by angiotensin II and angiotensin II type 1 receptor distribution in membrane microdomains. Hypertension 2008, 51:1332-1338.
13. -/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Br. J. Pharmacol. 2008, 153:1445-1455.
14. Yernool D., Boudker O., Jin Y., Gouaux E. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature 2004, 431:811-818.
15. + antiporter and insights into mechanism of action and regulation by pH. Nature 2005, 435:1197-1202.
16. Boudker O., Ryan R.M., Yernool D., Shimamoto K., Gouaux E. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 2007, 445:387-393.
17. Woost P.G., Orosz D.E., Jin W., Frisa P.S., Jacobberger J.W., Douglas J.G., Hopfer U. Immortalization and characterization of proximal tubule cells derived from kidneys of spontaneously hypertensive and normotensive rats. Kidney Int. 1996, 50:125-134.
18. Pinho M.J., Serrao M.P., Gomes P., Hopfer U., Jose P.A., Soares-da-Silva P. Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int. 2004, 66:216-226.
19. DeBlasi A., O'Reilly K., Motulsky H.J. Calculating receptor number from binding experiments using same compound as radioligand and competitor. Trends Pharmacol. Sci. 1989, 10:227-229.
20. H. Motulsky, Analyzing Data with GraphPad Prism, Version 3.0 ed., GraphPad Prism Software, 1999.
21. Pedrosa R., Gomes P., Hopfer U., Jose P.A., Soares-da-Silva P. Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event. Am. J. Physiol. Renal Physiol. 2004, 287:F1059-F1066.
22. Pedrosa R., Gomes P., Soares-da-Silva P. Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cells. Cell Physiol. Biochem. 2004, 14:91-100.
23. Mackenzie B., Erickson J.D. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch. 2004, 447:784-795.
24. Broer A., Klingel K., Kowalczuk S., Rasko J.E., Cavanaugh J., Broer S. Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder. J. Biol. Chem. 2004, 279:24467-24476.
25. Touyz R.M. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?. Hypertension 2004, 44:248-252.
26. Lassegue B., Griendling K.K. Reactive oxygen species in hypertension; an update. Am. J. Hypertens. 2004, 17:852-860.
27. Baumer A.T., Kruger C.A., Falkenberg J., Freyhaus H.T., Rosen R., Fink K., Rosenkranz S. The NAD(P)H oxidase inhibitor apocynin improves endothelial NO/superoxide balance and lowers effectively blood pressure in spontaneously hypertensive rats: comparison to calcium channel blockade. Clin. Exp. Hypertens. 2007, 29:287-299.
28. Bedard K., Krause K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 2007, 87:245-313.
29. Krishnamurthy H., Piscitelli C.L., Gouaux E. Unlocking the molecular secrets of sodium-coupled transporters. Nature 2009, 459:347-355.
30. --dependent neurotransmitter transporters. Nature 2005, 437:215-223.
31. Forrest L.R., Zhang Y.W., Jacobs M.T., Gesmonde J., Xie L., Honig B.H., Rudnick G. Mechanism for alternating access in neurotransmitter transporters. Proc. Natl. Acad. Sci. USA 2008, 105:10338-10343.
32. (2+)-induced oxidative stress. J. Neurochem. 1996, 67:1153-1163.
33. Rego A.C., Santos M.S., Oliveira C.R. Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells. J. Neurochem. 1996, 66:2506-2516.
34. Miyamoto M., Murphy T.H., Schnaar R.L., Coyle J.T. Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line. J. Pharmacol. Exp. Ther. 1989, 250:1132-1140.
35. Volterra A., Trotti D., Racagni G. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol. Pharmacol. 1994, 46:986-992.