Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemia

Journal of Medical Virology

Volumn 71, Issue 3, 2003, Pages 446-455

  Yin, Luo ^a   Al Alem, Umaima ^a   Liang, Jun ^a   Tong, Wei Min ^a   Li, Cuiling ^a   Badiali, Manuela ^a,b   Médard, Jean Jacques ^a   Sumegi, Janos ^c   Wang, Zhao Qi ^a   Romeo, Giovanni ^a,d  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b Osp Regionale per le Microcitemie   (Italy)

^c Cincinnati Childre's Hospital Medical Center   (United States)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Immunodeficiency; Immunoglobulin production; sap knockout; T lymphocyte proliferation

Indexed keywords

CD8 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EPSTEIN BARR VIRUS; ERYTHROPHAGOCYTOSIS; EXON; GAMMAHERPESVIRUS 68; GENE; GENE MUTATION; HERPES VIRUS; IMMUNOGLOBULIN DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; IMMUNOPATHOLOGY; LYMPHOCYTE PROLIFERATION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PHENOTYPE; SAP GENE; T LYMPHOCYTE; TISSUE INJURY; VIRUS INFECTION; VIRUS REACTIVATION; X CHROMOSOME LINKED DISORDER;

AGAMMAGLOBULINEMIA; ANIMALS; CARRIER PROTEINS; CELL LINE; CRICETINAE; DISEASE MODELS, ANIMAL; GAMMAHERPESVIRINAE; GENE DELETION; HERPESVIRIDAE INFECTIONS; HUMANS; IMMUNOGLOBULIN G; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; LUNG; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES; VIRUS ACTIVATION;

HUMAN HERPESVIRUS 4; MURINAE;

EID: 0141535212     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.10504     Document Type: Article

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