A physiological role for inducible FOXP3+ TREG cells. Lessons from women with reproductive failure.

Clinical Immunology

Volumn 136, Issue 3, 2010, Pages 432-441

  Arruvito, Lourdes ^a,b   Sotelo, Ana I ^b   Billordo, Ariel ^a   Fainboim, Leonardo ^a,b  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Human reproduction; IL 2; Inducible Treg cells; STAT 5

Indexed keywords

INTERLEUKIN 2; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CELL DIVISION; CELL EXPANSION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT ABORTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPONTANEOUS ABORTION; T LYMPHOCYTE ACTIVATION; WOMEN'S HEALTH;

EID: 77955266463     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.05.002     Document Type: Article

References (44)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22:531-562.
2. Fainboim L., Navarrete C., Festenstein H. Precursor and effector phenotypes of activated human T lymphocytes. Nature 1980, 288:391-393.
3. Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 2003, 3:253-257.
4. + regulatory T cells and for expansion of these cells. J. Immunol. 2007, 178:2018-2027.
5. Davidson T.S., DiPaolo R.J., Andersson J., Shevach E.M. Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J. Immunol. 2007, 178:4022-4026.
6. + regulatory T cells. J. Exp. Med. 2005, 201:1061-1067.
7. + regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J. Immunol. 2007, 178:2572-2578.
8. Prieto G.A., Rosenstein Y. Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation. Immunology 2006, 118:58-65.
9. + regulatory T cell compartment. J. Immunol. 2004, 173:2227-2230.
10. + regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 2004, 10:347-353.
11. + regulatory T-cell subset. Immunology 2004, 112:38-43.
12. bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J. Immunol. 2008, 180:5737-5745.
13. Liyanage U.K., Goedegebuure P.S., Moore T.T., Viehl C.T., Moo-Young T.A., Larson J.W., Frey D.M., Ehlers J.P., Eberlein T.J., Linehan D.C. Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. J. Immunother. 2006, 29:416-424.
14. + regulatory T-cell population by non-Hodgkin lymphoma. Blood 2008, 111:5359-5370.
15. + T cells in the circulation of patients with squamous cell carcinoma of the head and neck. Clin. Cancer Res. 2007, 13:6301-6311.
16. Li L., Li S.P., Min J., Zheng L. Hepatoma cells inhibit the differentiation and maturation of dendritic cells and increase the production of regulatory T cells. Immunol. Lett. 2007, 114:38-45.
17. Haas J., Schopp L., Storch-Hagenlocher B., Fritzsching B., Jacobi C., Milkova L., Fritz B., Schwarz A., Suri-Payer E., Hensel M., Wildemann B. Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis. Blood 2008, 111:761-766.
18. Liu Z., Kim J.H., Falo L.D., You Z. Tumor regulatory T cells potently abrogate antitumor immunity. J. Immunol. 2009, 182:6160-6167.
19. + regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients. Clin. Cancer Res. 2009, 15:1046-1051.
20. + T regulatory cells show strong prognostic significance in colorectal cancer. J. Clin. Oncol. 2009, 27:186-192.
21. Itose I., Kanto T., Kakita N., Takebe S., Inoue M., Higashitani K., Miyazaki M., Miyatake H., Sakakibara M., Hiramatsu N., Takehara T., Kasahara A., Hayashi N. Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis. J. Viral Hepat. 2009, 16:844-852.
22. Tran T.A., de Goer M.G., de Herve H., Hendel-Chavez B.Dembele, Le Nevot E., Abbed K., Pallier C., Goujard C., Gasnault J., Delfraissy J.F., Balazuc A.M., Taoufik Y. Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy. PLoS ONE 2008, 3:e3305.
23. + regulatory T cells in hepatitis C virus infection. J. Virol. 2008, 82:5043-5053.
24. + Treg in HIV-1-infected patients with low CD4 counts. Eur. J. Immunol. 2009, 39:301-309.
25. Guerin L.R., Prins J.R., Robertson S.A. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?. Hum. Reprod. Update 2009, 15:517-535.
26. Trowsdale J., Betz A.G. Mother's little helpers: mechanisms of maternal-fetal tolerance. Nat. Immunol. 2006, 7:241-246.
27. Malek T.R. The biology of interleukin-2. Annu. Rev. Immunol. 2008, 26:453-479.
28. Murray P.J. The JAK-STAT signaling pathway: input and output integration. J. Immunol. 2007, 178:2623-2629.
29. + regulatory T cells. Nat. Med. 2005, 11:1238-1243.
30. Yao Z., Kanno Y., Kerenyi M., Stephens G., Durant L., Watford W.T., Laurence A., Robinson G.W., Shevach E.M., Moriggl R., Hennighausen L., Wu C., O'Shea J.J. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 2007, 109:4368-4375.
31. Popmihajlov Z., Smith K.A. Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity. PLoS ONE 2008, 3:e1581.
32. Smith K.A., Popmihajlov Z. The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response. Immunol. Rev. 2008, 224:124-140.
33. + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J. Clin. Invest. 2009, 119:551-564.
34. + T regulatory cell generation. Transplantation 2009, 88:1303-1311.
35. + T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036.
36. Horwitz D.A., Zheng S.G., Gray J.D. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 2008, 29:429-435.
37. + regulatory T cells. J. Immunol. 2007, 178:280-290.
38. + regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
39. Kishimoto T. Interleukin-6 and its receptor in autoimmunity. J. Autoimmun. 1992, (5 Suppl A):123-132.
40. + T cell regulatory functions. J. Immunol. 2007, 178:271-279.
41. Longhi M.P., Wright K., Lauder S.N., Nowell M.A., Jones G.W., Godkin A.J., Jones S.A., Gallimore A.M. Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells. PLoS Pathog. 2008, 4:e1000006.
42. +CD25 T cells. J. Immunol. 2007, 179:2041-2045.
43. + cells in women with reproductive failure. J. Reprod. Immunol. 2009, 82:158-165.
44. + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 2008, 180:7112-7116.