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Volumn 16, Issue 12, 2009, Pages 844-852

Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis

Author keywords

HCV; PNALT; Regulatory T cell

Indexed keywords

ALANINE AMINOTRANSFERASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 70449411040     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01131.x     Document Type: Article
Times cited : (26)

References (36)
  • 1
    • 17344369924 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group
    • Kasahara A, Hayashi N, Mochizuki K et al. Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group. Hepatology 1998 27 (5 1394 1402.
    • (1998) Hepatology , vol.27 , Issue.5 , pp. 1394-1402
    • Kasahara, A.1    Hayashi, N.2    Mochizuki, K.3
  • 2
    • 0030955348 scopus 로고    scopus 로고
    • Therapy of hepatitis C: Patients with normal aminotransferase levels
    • Marcellin P, Levy S, Erlinger S. Therapy of hepatitis C: patients with normal aminotransferase levels. Hepatology 1997 26 (3 Suppl. 1 133S 136S.
    • (1997) Hepatology , vol.26 , Issue.31
    • Marcellin, P.1    Levy, S.2    Erlinger, S.3
  • 3
    • 0033431808 scopus 로고    scopus 로고
    • Treatment of patients with chronic hepatitis C and normal ALT levels
    • Tassopoulos NC. Treatment of patients with chronic hepatitis C and normal ALT levels. J Hepatol 1999 31 (Suppl. 1 193 196.
    • (1999) J Hepatol , vol.31 , Issue.1 , pp. 193-196
    • Tassopoulos, N.C.1
  • 4
    • 85005773666 scopus 로고    scopus 로고
    • Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels
    • Persico M, Persico E, Suozzo R et al. Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels. Gastroenterology 2000 118 (4 760 764.
    • (2000) Gastroenterology , vol.118 , Issue.4 , pp. 760-764
    • Persico, M.1    Persico, E.2    Suozzo, R.3
  • 5
    • 33646515338 scopus 로고    scopus 로고
    • Alanine aminotransferase level as a predictor of hepatitis C virus-associated hepatocellular carcinoma incidence in a community-based population in Japan
    • Suruki R, Hayashi K, Kusumoto K et al. Alanine aminotransferase level as a predictor of hepatitis C virus-associated hepatocellular carcinoma incidence in a community-based population in Japan. Int J Cancer 2006 119 (1 192 195.
    • (2006) Int J Cancer , vol.119 , Issue.1 , pp. 192-195
    • Suruki, R.1    Hayashi, K.2    Kusumoto, K.3
  • 6
    • 0031068032 scopus 로고    scopus 로고
    • The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C
    • Nelson DR, Marousis CG, Davis GL et al. The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J Immunol 1997 158 (3 1473 1481.
    • (1997) J Immunol , vol.158 , Issue.3 , pp. 1473-1481
    • Nelson, D.R.1    Marousis, C.G.2    Davis, G.L.3
  • 7
    • 0033849629 scopus 로고    scopus 로고
    • Liver-derived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma
    • Schirren CA, Jung MC, Gerlach JT et al. Liver-derived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma. Hepatology 2000 32 (3 597 603.
    • (2000) Hepatology , vol.32 , Issue.3 , pp. 597-603
    • Schirren, C.A.1    Jung, M.C.2    Gerlach, J.T.3
  • 8
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • DOI 10.1146/annurev.immunol.21.120601.141122
    • Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004 22 : 531 562. (Pubitemid 38680433)
    • (2004) Annual Review of Immunology , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 9
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004 199 (7 971 979.
    • (2004) J Exp Med , vol.199 , Issue.7 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 10
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein MR, Evans JG, Singh A et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004 200 (3 277 285.
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3
  • 11
    • 10844222790 scopus 로고    scopus 로고
    • Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: Mechanism underlying unrestrained pathogenic effector T cell proliferation
    • Sugiyama H, Gyulai R, Toichi E et al. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005 174 (1 164 173.
    • (2005) J Immunol , vol.174 , Issue.1 , pp. 164-173
    • Sugiyama, H.1    Gyulai, R.2    Toichi, E.3
  • 12
    • 8644280556 scopus 로고    scopus 로고
    • Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
    • Weiss L, Donkova-Petrini V, Caccavelli L, Balbo M, Carbonneil C, Levy Y. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004 104 (10 3249 3256.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3249-3256
    • Weiss, L.1    Donkova-Petrini, V.2    Caccavelli, L.3    Balbo, M.4    Carbonneil, C.5    Levy, Y.6
  • 13
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, Korangy F. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 2005 65 (6 2457 2464.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2457-2464
    • Ormandy, L.A.1    Hillemann, T.2    Wedemeyer, H.3    Manns, M.P.4    Greten, T.F.5    Korangy, F.6
  • 14
    • 0346996879 scopus 로고    scopus 로고
    • The regulatory T cell family: Distinct subsets and their interrelations
    • Jonuleit H, Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol 2003 171 (12 6323 6327.
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6323-6327
    • Jonuleit, H.1    Schmitt, E.2
  • 15
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 299 (5609 1057 1061.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 16
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005 6 (4 331 337.
    • (2005) Nat Immunol , vol.6 , Issue.4 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 17
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • Cabrera R, Tu Z, Xu Y et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004 40 (5 1062 1071.
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3
  • 18
    • 19944366276 scopus 로고    scopus 로고
    • Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection
    • Rushbrook SM, Ward SM, Unitt E et al. Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 2005 79 (12 7852 7859.
    • (2005) J Virol , vol.79 , Issue.12 , pp. 7852-7859
    • Rushbrook, S.M.1    Ward, S.M.2    Unitt, E.3
  • 19
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003 38 (6 1437 1448.
    • (2003) Hepatology , vol.38 , Issue.6 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 20
    • 34547604820 scopus 로고    scopus 로고
    • Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection
    • Ward SM, Fox BC, Brown PJ et al. Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection. J Hepatol 2007 47 (3 316 324.
    • (2007) J Hepatol , vol.47 , Issue.3 , pp. 316-324
    • Ward, S.M.1    Fox, B.C.2    Brown, P.J.3
  • 21
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003 198 (12 1875 1886.
    • (2003) J Exp Med , vol.198 , Issue.12 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 22
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells
    • Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells. J Exp Med 2006 203 (7 1701 1711.
    • (2006) J Exp Med , vol.203 , Issue.7 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 23
    • 0031962298 scopus 로고    scopus 로고
    • Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus
    • Kuzushita N, Hayashi N, Moribe T et al. Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus. Hepatology 1998 27 (1 240 244.
    • (1998) Hepatology , vol.27 , Issue.1 , pp. 240-244
    • Kuzushita, N.1    Hayashi, N.2    Moribe, T.3
  • 24
    • 24944452287 scopus 로고    scopus 로고
    • Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels
    • Kanto T, Inoue M, Miyazaki M et al. Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels. Intervirology 2006 49 (1-2 58 63.
    • (2006) Intervirology , vol.49 , Issue.12 , pp. 58-63
    • Kanto, T.1    Inoue, M.2    Miyazaki, M.3
  • 25
    • 0141866945 scopus 로고    scopus 로고
    • Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C
    • Leroy V, Vigan I, Mosnier JF et al. Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C. Hepatology 2003 38 (4 829 841.
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 829-841
    • Leroy, V.1    Vigan, I.2    Mosnier, J.F.3
  • 26
    • 0036237824 scopus 로고    scopus 로고
    • Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: Functional characterization in patients with chronic hepatitis C
    • Penna A, Missale G, Lamonaca V et al. Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: functional characterization in patients with chronic hepatitis C. Hepatology 2002 35 (5 1225 1236.
    • (2002) Hepatology , vol.35 , Issue.5 , pp. 1225-1236
    • Penna, A.1    Missale, G.2    Lamonaca, V.3
  • 27
    • 19944370822 scopus 로고    scopus 로고
    • T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection
    • Boettler T, Spangenberg HC, Neumann-Haefelin C et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005 79 (12 7860 7867.
    • (2005) J Virol , vol.79 , Issue.12 , pp. 7860-7867
    • Boettler, T.1    Spangenberg, H.C.2    Neumann-Haefelin, C.3
  • 28
    • 37149003363 scopus 로고    scopus 로고
    • Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
    • Venken K, Hellings N, Thewissen M et al. Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 2008 123 (1 79 89.
    • (2008) Immunology , vol.123 , Issue.1 , pp. 79-89
    • Venken, K.1    Hellings, N.2    Thewissen, M.3
  • 29
    • 33645857965 scopus 로고    scopus 로고
    • Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels
    • Bolacchi F, Sinistro A, Ciaprini C et al. Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels. Clin Exp Immunol 2006 144 (2 188 196.
    • (2006) Clin Exp Immunol , vol.144 , Issue.2 , pp. 188-196
    • Bolacchi, F.1    Sinistro, A.2    Ciaprini, C.3
  • 30
    • 34247895580 scopus 로고    scopus 로고
    • Defining target antigens for CD25+ FOXP3+ IFN-gamma-regulatory T cells in chronic hepatitis C virus infection
    • Li S, Jones KL, Woollard DJ et al. Defining target antigens for CD25+ FOXP3+ IFN-gamma-regulatory T cells in chronic hepatitis C virus infection. Immunol Cell Biol 2007 85 (3 197 204.
    • (2007) Immunol Cell Biol , vol.85 , Issue.3 , pp. 197-204
    • Li, S.1    Jones, K.L.2    Woollard, D.J.3
  • 31
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006 203 (7 1693 1700.
    • (2006) J Exp Med , vol.203 , Issue.7 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 32
    • 34547204632 scopus 로고    scopus 로고
    • Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    • You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci USA 2007 104 (15 6335 6340.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.15 , pp. 6335-6340
    • You, S.1    Leforban, B.2    Garcia, C.3    Bach, J.F.4    Bluestone, J.A.5    Chatenoud, L.6
  • 33
    • 63149094153 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of CD4+CD25- Foxp3+ T cells in patients with systemic lupus erythematosus
    • Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C. Phenotypic and functional analysis of CD4+CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol 2009 182 (3 1689 1695.
    • (2009) J Immunol , vol.182 , Issue.3 , pp. 1689-1695
    • Bonelli, M.1    Savitskaya, A.2    Steiner, C.W.3    Rath, E.4    Smolen, J.S.5    Scheinecker, C.6
  • 34
    • 15244340167 scopus 로고    scopus 로고
    • Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion
    • Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J. Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 2005 102 (11 4091 4096.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.11 , pp. 4091-4096
    • Zelenay, S.1    Lopes-Carvalho, T.2    Caramalho, I.3    Moraes-Fontes, M.F.4    Rebelo, M.5    Demengeot, J.6
  • 35
    • 24344456500 scopus 로고    scopus 로고
    • A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase
    • Okanoue T, Makiyama A, Nakayama M et al. A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. J Hepatol 2005 43 (4 599 605.
    • (2005) J Hepatol , vol.43 , Issue.4 , pp. 599-605
    • Okanoue, T.1    Makiyama, A.2    Nakayama, M.3
  • 36
    • 0033861568 scopus 로고    scopus 로고
    • Effect of interferon therapy on the incidence of hepatocellular carcinoma and mortality of patients with chronic hepatitis C: A retrospective cohort study of 738 patients
    • Tanaka H, Tsukuma H, Kasahara A et al. Effect of interferon therapy on the incidence of hepatocellular carcinoma and mortality of patients with chronic hepatitis C: a retrospective cohort study of 738 patients. Int J Cancer 2000 87 (5 741 749.
    • (2000) Int J Cancer , vol.87 , Issue.5 , pp. 741-749
    • Tanaka, H.1    Tsukuma, H.2    Kasahara, A.3


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