The human "treg MLR": Immune monitoring for FOXP3+ T regulatory cell generation

Transplantation

Volumn 88, Issue 11, 2009, Pages 1303-1311

  Levitsky, Josh ^a   Miller, Joshua ^a,b   Leventhal, Joseph ^a   Huang, Xuemei ^a   Flaa, Cathy ^a   Wang, Edward ^a   Tambur, Anat ^a   Burt, Richard K ^a   Gallon, Lorenzo ^a   Mathew, James M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

FOXP3 cells.; Human Tregs; Immune monitoring assay; Mixed lymphocyte reaction

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 7 RECEPTOR; LEUKOCYTE ANTIGEN; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; HLA ANTIGEN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL LINE; CELL PROLIFERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOASSAY; IN VITRO STUDY; KIDNEY FAILURE; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ANTIGEN PRESENTATION; CELL CULTURE; HISTOCOMPATIBILITY; IMMUNOLOGY; KIDNEY TRANSPLANTATION; MIXED LYMPHOCYTE CULTURE; PREDICTION AND FORECASTING; TIME; TRANSPLANTATION TOLERANCE;

ANTIGEN PRESENTATION; ANTIGENS, CD3; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HISTOCOMPATIBILITY; HLA ANTIGENS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY TRANSPLANTATION; LYMPHOCYTE CULTURE TEST, MIXED; PREDICTIVE VALUE OF TESTS; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION TOLERANCE;

EID: 73349141741     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181bbee98     Document Type: Article

References (29)

1. + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345.
2. + regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006; 177: 8338.
3. Pillai V, Ortega SB, Wang CK, et al. Transient regulatory T-cells: A state attained by all activated human T-cells. Clin Immunol 2007; 123: 18.
4. + regulatory T cell: A jack of all trades, master of regulation. Nat Immunol 2008; 9: 239.
5. Fathman CG, Collavo D, Davies S, et al. In vitro secondary MLR. I. Kinetics of proliferation and specificity of in vitro primed responder cells. J Immunol 1977; 118: 1232.
6. Weston SA, Parish CR. New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy. J Immunol Methods 1990; 133: 87.
7. Lyons AB. Divided we stand: Tracking cell proliferation with car-boxyfluorescein diacetate succinimidyl ester. Immunol Cell Biol 1999; 77: 509.
8. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151.
9. Mays LE, Chen YH. Maintaining immunological tolerance with Foxp3. Cell Res 2007; 17: 904.
10. + Tregs. J Clin Invest 2005; 115: 2904.
11. + T cells in aged mice. J Immunol 2006; 176: 6586.
12. Demirkiran A, Baan CC, Kok A, et al. Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy. Transplantation 2007; 83: 819.
13. Dijke IE, Caliskan K, Korevaar SS, et al. FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients. Transpl Immunol 2008; 18: 250.
14. + cells in renal allografts during acute rejection. Am J Transplant 2007; 7: 914.
15. Muthukumar T, Dadhania D, Ding R, et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. NEngl J Med 2005; 353: 2342.
16. Li Y, Zhao X, Cheng D, et al. The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients. Transplantation 2008; 86: 1837.
17. +T cells/ FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation 2006; 81: 398.
18. + regulatory T cells ex vivo. Blood 2003; 102: 2180.
19. + regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients. J Am Soc Nephrol2003; 14: 1652.
20. Hernandez A, Burger M, Blomberg BB, et al. Inhibition of NF-kappa B during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches. Hum Immunol 2007; 68: 715.
21. Mirenda V, Berton I, Read J, et al. Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: An efficient way to induce indirect pathway regulation. J Am Soc Nephrol 2004; 15: 987.
22. Jiang S, Herrera O, Lechler RI. New spectrum of allorecognition pathways: Implications for graft rejection and transplantation tolerance. Curr Opin Immunol 2004; 16: 550.
23. Reichardt P, Dornbach B, Rong S, et al. Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood 2007; 110: 1519.
24. + regulatory T cells that prevent allograft rejection: Potential avenues for cellular therapy. Transplantation 2008; 86: 578.
25. +CD25 low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol 2007; 178: 3983.
26. Jin Y, Hernandez A, Fuller L, et al. A novel approach to detect donor/ recipent immune responses between HLA-identical pairs. Hum Immunol 2007; 68: 350.
27. Huter EN, Stummvoll GH, DiPaolo RJ, et al. Cutting edge: Antigen-specific TGFbeta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J Immunol 2008; 181: 8209.
28. + regulatory T cells including suppressors of alloreactivity. Immunol Rev 2006; 212: 314.
29. + regulatory T cells. Int Immunol 2004; 16: 1189.